Photo of Kiira Ratia

Kiira Ratia


Associate Director, UICentre for Drug Discovery

Email:

kratia@uic.edu

Related Sites:

Selected Grants

Identification of small molecules to improve efficacy of cancer immunotherapy, Chancellor's Translational Research Initiative., 6/1/2024 - 9/30/2024, Obligated Amount: $25000; Anticipated Amount: $25000

COVID19 - Targeting SARS-CoV-2 PLpro for COVID-19 treatment, University of Arizona., 4/1/2022 - 1/31/2027, Obligated Amount: $385437; Anticipated Amount: $385437

Development of Small Molecule Inhibitors of G12 / Alpha-SNAP-dependent vWF Secretion, Chicago Biomedical Consortium., 10/1/2021 - 9/30/2025, Obligated Amount: $250000; Anticipated Amount: $250000

Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics, National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases)., 9/17/2020 - 7/31/2025, Obligated Amount: $1488932; Anticipated Amount: $1494424

Development of GCN2 inhibitors to potentiate the activity of asparaginases, US Dept of Veterans Affairs (Medical Research Ser)., 8/15/2020 - 8/14/2021, Obligated Amount: $40000; Anticipated Amount: $40000

Using a Novel Model of Antidepressant Efficacy to Discover New Compounds and Personalized Treatments, Pax Neuroscience., 9/20/2017 - 8/31/2020, Obligated Amount: $350309; Anticipated Amount: $350309

Therapeutic Targeting of Carotid Body for Sleep-Disordered Breathing, University of Chicago., 9/22/2014 - 6/30/2016, Obligated Amount: $1518448; Anticipated Amount: $1518448

Cblb-based Drugs Against Sepsis and Inflammation, Cell Biologics Inc., 9/15/2014 - 9/14/2015, Obligated Amount: $118749; Anticipated Amount: $118749

Discovery Of Novel Anti-HBV Compounds Targetaing Host Factors, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 9/9/2013 - 8/31/2016, Obligated Amount: $419721; Anticipated Amount: $419721

Selected Publications

Sacramento, Carolina Q, Bott, Ryan, Huang, Qinfeng, Eaton, Brett, Postnikova, Elena, Sabir, Ahmad J, Argade, Malaika D, Ratia, Kiira, Anantpadma, Manu, Carlier, Paul R, Ly, Hinh, Liang, Yuying, Rong, Lijun. (2025). Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses. Antiviral Research, 236, 106117. doi:10.1016/j.antiviral.2025.106117.

Velma, Ganga Reddy, Shen, Zhengnan, Holberg, Cameron, Fu, Jiqiang, Soleymani, Farinaz, Cooper, Laura, Ramos, Omar Lozano, Indukuri, Divakar, Musku, Soumya Reddy, Rychetsky, Pavel, Slilaty, Steve, Li, Zuomei, Ratia, Kiira, Rong, Lijun, Schenten, Dominik, Xiong, Rui, Thatcher, Gregory RJ. (2024). Non-Covalent Inhibitors of SARS-CoV‑2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity. Journal of Medicinal Chemistry, 67, (16), 13681-13702. doi:10.1021/acs.jmedchem.4c00378.

Rusu, Luiza, Bloem, Laura J, Chen, Hui, Lee, Hyun, Ratia, Kiira M, Jayathilaka, Lasanthi, Carlier, Paul R, Minshall, Richard D. (2024). Abstract 1063: G Protein 12 Alpha Subunit Covalent Binding To Alpha-snap And Its Potential Role In Von Willebrand Factor Secretion. Arteriosclerosis Thrombosis and Vascular Biology, 44, (Suppl_1), a1063-a1063. doi:10.1161/atvb.44.suppl_1.1063.

Li, Yangfeng, Shen, Zhengnan, Ratia, Kiira, Zhao, Jiong, Huang, Fei, Dubrovyskyii, Oleksii, Indukuri, Divakar, Fu, Jiqiang, Ramos, Omar Lozano, Thatcher, Gregory RJ, Xiong, Rui. (2024). Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors. Journal of Medicinal Chemistry, 67, (4), 2712-2731. doi:10.1021/acs.jmedchem.3c01837.

Gordon-Blake, Jesse, Ratia, Kiira, Weidig, Victoria, Velma, Ganga Reddy, Ackerman-Berrier, Martha, Penton, Christopher, Musku, Soumya Reddy, Alves, Erick TM, Driver, Tom, Tai, Leon, Thatcher, Gregory RJ. (2024). Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS Medicinal Chemistry Letters, 15, (2), 205-214. doi:10.1021/acsmedchemlett.3c00391.

Shen, Zhengnan, Ratia, Kiira, Krider, Isabella, Ackerman-Berrier, Martha, Penton, Christopher, Musku, Soumya Reddy, Gordon-Blake, Jesse M, Laham, Megan S, Christie, Nicholas, Ma, Nina, Fu, Jiqiang, Xiong, Rui, Courey, Jenna M, Velma, Ganga Reddy, Thatcher, Gregory RJ. (2023). Synthesis, Optimization, and Structure–Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs). Journal of Medicinal Chemistry, 66, (24), 16704-16727. doi:10.1021/acs.jmedchem.3c01406.

Ratia, Kiira M, Shen, Zhengnan, Gordon-Blake, Jesse, Lee, Hyun, Laham, Megan S, Krider, Isabella S, Christie, Nicholas, Ackerman-Berrier, Martha, Penton, Christopher, Knowles, Natalie G, Musku, Soumya Reddy, Fu, Jiqiang, Velma, Ganga Reddy, Xiong, Rui, Thatcher, Gregory RJ. (2023). Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD+. Biochemistry, 62, (4), 923-933. doi:10.1021/acs.biochem.2c00655.

Serrano, Jose, Laughlin, Maren R, Bellin, Melena D, Yadav, Dhiraj, Chinchilli, Vernon M, Andersen, Dana K. (2022). Type 1 Diabetes in Acute Pancreatitis Consortium. Pancreas, 51, (6), 563-567. doi:10.1097/mpa.0000000000002073.

Shen, Zhengnan, Ratia, Kiira, Cooper, Laura, Kong, Deyu, Lee, Hyun, Kwon, Youngjin, Li, Yangfeng, Alqarni, Saad, Huang, Fei, Dubrovskyi, Oleksii, Rong, Lijun, Thatcher, Gregory RJ, Xiong, Rui. (2022). Design of SARS-CoV‑2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity. Journal of Medicinal Chemistry, 65, (4), 2940-2955. doi:10.1021/acs.jmedchem.1c01307.

Education

Degrees:
PhD, University of Illinois at Chicago, United States, 2008
BS, Haverford College, United States, 1999

Selected Presentations

Bae, M, Lee, H, Bloem, LJ, Ratia, K, Du, X, Minshall, Richard. (2019 April 01). Development of novel cell-permeable Gα12-αSNAP binding domain peptide and small molecules for inhibiting microvascular thrombosis associated with cancer and cancer treatment. Gary Kruh Cancer Research Symposium. Chicago, IL. USA..