Photo of David C Lankin

David C Lankin


Research Associate Professor, Medicinal Chemistry and Pharmacognosy

Contact

Address:

833 S. Wood Street, Chicago, IL, 60612

Selected Publications

  • Simmler C, Anderson JR, Gauthier LL, Lankin DC, McAlpine JB, Chen S, Pauli GF. Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals.. Journal of natural products. 2015;78(8):2007-22. doi:10.1021/acs.jnatprod.5b00342.
  • Napolitano JG, Simmler C, McAlpine JB, Lankin DC, Chen S, Pauli GF. Digital NMR profiles as building blocks: assembling ¹H fingerprints of steviol glycosides.. Journal of natural products. 2015;78(4):658-65. doi:10.1021/np5008203.
  • Ramos Alvarenga RF, Friesen JB, Nikolic DS, Simmler C, Napolitano JG, van Breemen RB, Lankin DC, McAlpine JB, Pauli GF, Chen S. K-targeted metabolomic analysis extends chemical subtraction to DESIGNER extracts: selective depletion of extracts of hops (Humulus lupulus).. Journal of natural products. 2014;77(12):2595-604. doi:10.1021/np500376g.
  • Gao WY, Kim J, Chen S, Cho SU, Choi JY, Jaki BC, Jin YE, Lankin DY, Lee JG, Lee SG, Napolitano JW, Franzblau SF, Suh J, Pauli G. Discovery and characterization of the tuberculosis drug lead ecumicin.. Organic letters. 2014;16(23):6044-7. doi:10.1021/ol5026603.
  • Pauli GF, Chen S, Simmler C, Lankin DC, Gödecke TU, Jaki BB, Friesen JB, McAlpine JG, Napolitano J. Importance of purity evaluation and the potential of quantitative ¹H NMR as a purity assay.. Journal of medicinal chemistry. 2014;57(22):9220-31. doi:10.1021/jm500734a.
  • Simmler C, Nikolic DS, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte AF, Le Quémener C, Audo G, Pauli G. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.. Journal of natural products. 2014;77(8):1806-16. doi:10.1021/np5001945.
  • Simmler C, Nikolić DC, Lankin D, Yu YB, van Breemen RF, Lecomte A, Le Quémener C, Audo G, Pauli G. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice.. Journal of natural products. 2014;. doi:10.1021/np5001945.
  • Elkington BG, Sydara KH, Newsome AC, Hwang C, Lankin DG, Simmler CG, Napolitano JF, Ree RG, Graham JD, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli G, Franzblau S, Soejarto D. New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.. Journal of ethnopharmacology. 2014;151(2):903-11. doi:10.1016/j.jep.2013.11.057.
  • Elkington BG, Sydara KH, Newsome AC, Hwang C, Lankin DG, Simmler CG, Napolitano JF, Ree RG, Graham JD, Gyllenhaal C, Bouamanivong S, Souliya O, Pauli G, Franzblau S, Soejarto D. New finding of an anti-TB compound in the genus Marsypopetalum (Annonaceae) from a traditional herbal remedy of Laos.. Journal of ethnopharmacology. 2014;151(2):903-11. doi:10.1016/j.jep.2013.11.057.
  • Klein L, Petukhova V, Wan B, Wang YD, Santasiero BC, Lankin DF, Pauli GG, Franzblau S. A novel indigoid anti-tuberculosis agent.. Bioorganic & medicinal chemistry letters. 2014;24(1):268-70. doi:10.1016/j.bmcl.2013.11.024.
  • Dong SH, Cai GG, Napolitano JC, Nikolić DB, Lankin DD, van Breemen RF, Soejarto D, Pauli G, Chen S. Lipidated steroid saponins from Dioscorea villosa (wild yam).. Fitoterapia. 2013;91:113-24. doi:10.1016/j.fitote.2013.07.018.
  • Hwang CH, Jaki BU, Klein L, Lankin DC, Napolitano JG, Fryling NA, Franzblau SG, Cho S, Stamets PE, Wang YF, Pauli G. Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.. Journal of natural products. 2013;76(10):1916-22. doi:10.1021/np400497f.
  • Qiu FU, Cai GC, Jaki BG, Lankin DF, Franzblau S, Pauli G. Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.. Journal of natural products. 2013;76(3):413-9. doi:10.1021/np3007809.
  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones TD, Soejarto D, Chen SF, Pauli G. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.. Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.
  • Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones TD, Soejarto D, Chen SF, Pauli G. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay.. Journal of agricultural and food chemistry. 2013;61(9):2146-57. doi:10.1021/jf304445p.
  • Nikolić D, Gödecke TC, Chen SF, White JB, Lankin D, Pauli G, van Breemen R. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).. Fitoterapia. 2012;83(3):441-60. doi:10.1016/j.fitote.2011.12.006.
  • Hemachandra LP, Madhubhani P, Chandrasena RC, Esala PA, Chen SM, Main MF, Lankin DR, Scism RL, Dietz B, Pauli G, Thatcher G, Bolton J. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).. Cancer prevention research (Philadelphia, Pa.). 2012;5(1):73-81. doi:10.1158/1940-6207.CAPR-11-0348.
  • Gödecke TG, Yao PM, Napolitano JL, Nikolić DB, Dietz BR, Bolton J, van Breemen RC, Farnsworth NF, Chen S, Lankin D, Pauli G. Integrated standardization concept for Angelica botanicals using quantitative NMR.. Fitoterapia. 2012;83(1):18-32. doi:10.1016/j.fitote.2011.08.017.
  • Li J, Gödecke TC, Chen SR, Imai AF, Lankin DB, Farnsworth N, Pauli G, van Breemen R, Nikolić D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4.. Xenobiotica; the fate of foreign compounds in biological systems. 2011;. doi:10.3109/00498254.2011.603385.
  • Scher JM, Schinkovitz AG, Zapp JC, Wang YF, Franzblau S, Becker H, Lankin D, Pauli G. Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia.. Journal of natural products. 2010;73(4):656-63. doi:10.1021/np900806j.
  • Gödecke TC, Lankin DS, Nikolic D, Chen SB, van Breemen RR, Farnsworth NF, Pauli G. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).. Journal of natural products. 2009;72(3):433-7. doi:10.1021/np8006952.
  • Gödecke TS, Nikolic DC, Lankin D, Chen SL, Powell SM, Dietz BL, Bolton JB, van Breemen RR, Farnsworth NF, Pauli G. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.. Phytochemical analysis : PCA. 2009;20(2):120-33. doi:10.1002/pca.1106.
  • Powell SL, Gödecke TS, Nikolic D, Chen SM, Ahn SR, Dietz BB, Farnsworth NC, van Breemen RF, Lankin DL, Pauli G, Bolton J. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.. Journal of agricultural and food chemistry. 2008;56(24):11718-26. doi:10.1021/jf803298z.
  • Overk CR, Guo JR, Chadwick LD, Lantvit D, Minassi AC, Appendino GR, Chen SF, Lankin DB, Farnsworth NL, Pauli G, van Breemen R, Bolton J. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.. Chemico-biological interactions. 2008;176(1):30-9. doi:10.1016/j.cbi.2008.06.005.
  • Jaki BU, Franzblau SG, Chadwick LR, Lankin DC, Zhang FF, Wang Y, Pauli G. Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.. Journal of natural products. 2008;71(10):1742-8. doi:10.1021/np800329j.
  • Chen S, Lankin DC, Nikolic DS, Lu ZZ, Ramirez BB, van Breemen RH, Fong HR, Farnsworth NF, Pauli G. Chlorination diversifies Cimicifuga racemosa triterpene glycosides.. Journal of natural products. 2007;70(6):1016-23. doi:10.1021/np0700319.
  • Nikolic DS, Lankin DC, Chen S, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.. Journal of natural products. 2005;68(8):1266-70. doi:10.1021/np050066d.