Photo of Laura J Bloem

Laura J Bloem


Research Associate Professor, Pharmaceutical Sciences
Associate Director UICentre, UIC

Contact

Office Phone:

(312) 996-0087 (work)

Related Sites:

Selected Grants

Development of GCN2 inhibitors to potentiate the activity of asparaginases, US Dept of Veterans Affairs (Medical Research Ser)., 8/15/2020 - 8/14/2021, Obligated Amount: $40000; Anticipated Amount: $40000

Selected Publications

Ahmed, Emaad, Abdulridha, Zahir, Hartmanis, Nick, Gilchrist, Annette, Layden, Brian, Bloem, Laura. (2021). Investigation of the free fatty acid receptor 2 and its role in the treatment of type 2 diabetes mellitus. The FASEB Journal, 35, (S1). doi:10.1096/fasebj.2021.35.s1.02140.

Pérez Morales, Tiara G, Ratia, Kiira, Wang, Duo-Sheng, Gogos, Artemis, Bloem, Laura, Driver, Tom G, Federle, Michael J. (2018). A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO.. Journal of Biological Chemistry, 293, (12), 4580. doi:10.1074/jbc.aac118.002674.

Pérez Morales, Tiara G, Ratia, Kiira, Wang, Duo-Sheng, Gogos, Artemis, Bloem, Laura, Driver, Tom G, Federle, Michael J. (2017). A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. Journal of Biological Chemistry, 293, (3), 931-940. doi:10.1074/jbc.m117.810994.

Smith, Michele C, Mader, Mary M, Cook, James A, Iversen, Philip, Ajamie, Rose, Perkins, Everett, Bloem, Laura, Yip, Yvonne Y, Barda, David A, Waid, Philip P, Zeckner, Douglas J, Young, Debra A, Sanchez-Felix, Manuel, Donoho, Gregory P, Wacheck, Volker. (2016). Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth. Molecular Cancer Therapeutics, 15, (10), 2344-2356. doi:10.1158/1535-7163.mct-15-0996.

Ma, L, Clayton, JR, Walgren, RA, Zhao, B, Evans, RJ, Smith, MC, Heinz-Taheny, KM, Kreklau, EL, Bloem, L, Pitou, C, Shen, W, Strelow, JM, Halstead, C, Rempala, ME, Parthasarathy, S, Gillig, JR, Heinz, LJ, Pei, H, Wang, Y, Stancato, LF, Dowless, MS, Iversen, PW, Burkholder, TP. (2013). Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F. Blood Cancer Journal, 3, (4), e109. doi:10.1038/bcj.2013.6.

Bose, Suchira, Cavallini, Annalisa, Murray, Tracey, Baschirotto, Lisa, Czilli, Dan, Cella, Claire, Ward, Mark, Hanmer, Jenna, Sims, Helen, Eberle, Elizabeth, Simmons, Aaron, Sossick, Sandra, Cramer, Jeff, Calligaro, David, Mateo, Ana, Bloem, Laura, Nuthall, Hugh, O’Neill, Michael, Davies, Peter, Goedert, Michel, Hutton, Michael, Szekeres, Philip. (2012). P3‐025: Chronic inhibition of the MEK/ERK pathway fails to delay disease progression in a transgenic animal model of tauopathy. Alzheimer’s & Dementia, 8, (4S_Part_13), p463-p463. doi:10.1016/j.jalz.2012.05.1243.

Zhao, Genshi, Li, Wei-ying, Chen, Daohong, Henry, James R, Li, Hong-Yu, Chen, Zhaogen, Zia-Ebrahimi, Mohammad, Bloem, Laura, Zhai, Yan, Huss, Karen, Peng, Sheng-bin, McCann, Denis J. (2011). A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models. Molecular Cancer Therapeutics, 10, (11), 2200-2210. doi:10.1158/1535-7163.mct-11-0306.

Burkholder, Timothy P, Clayton, Joshua R, Rempala, Mark E, Henry, James R, Knobeloch, John M, Mendel, David, McLean, Johnathan A, Hao, Yan, Barda, David A, Considine, Eileen L, Uhlik, Mark T, Chen, Yuefeng, Ma, Liandong, Bloem, Laura J, Akunda, Jacqueline K, McCann, Denis J, Sanchez-Felix, Manuel, Clawson, David K, Lahn, Michael M, Starling, James J. (2011). Erratum to: Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. Investigational New Drugs, 30, (3), 1270-1271. doi:10.1007/s10637-011-9684-7.

Burkholder, Timothy P, Clayton, Joshua R, Rempala, Mark E, Henry, James R, Knobeloch, John M, Mendel, David, McLean, Johnathan A, Hao, Yan, Barda, David A, Considine, Eileen L, Uhlik, Mark T, Chen, Yuefeng, Ma, Liandong, Bloem, Laura J, Akunda, Jacqueline K, McCann, Denis J, Sanchez-Felix, Manuel, Clawson, David K, Lahn, Michael M, Starling, James J. (2011). Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. Investigational New Drugs, 30, (3), 936-949. doi:10.1007/s10637-011-9640-6.