Photo of Dr. Mike J Federle

Mike J Federle


Professor, Pharmaceutical Sciences
Director, Center for Biomolecular Sciences

Contact

Building & Room:

3152 MBRB

Address:

900 S. Ashland Ave, Chicago, IL, 60607

Office Phone:

(312) 413-0213

CV Link:

Mike J Federle

Selected Publications

  • Cook LCC , Chatterjee N, Li Y, Andrade J, Federle M, Eichenbaum Z. Transcriptomic Analysis of Streptococcus pyogenes Colonizing the Vaginal Mucosa Identifies hupY, an MtsR-Regulated Adhesin Involved in Heme Utilization.. mBio. 2019;10(3). doi:10.1128/mBio.00848-19.
  • Gogos A, Federle M. Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse.. Frontiers in cellular and infection microbiology. 2019;9:137. doi:10.3389/fcimb.2019.00137.
  • Pavlova SI, Wilkening RV, Federle M, Lu Y, Schwartz J, Tao L. Streptococcus endopeptidases promote HPV infection in vitro.. MicrobiologyOpen. 2019;8(1):e00628. doi:10.1002/mbo3.628.
  • Mashburn-Warren L, Goodman SD, Federle M, Prehna G. The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus.. Scientific reports. 2018;8(1):16535. doi:10.1038/s41598-018-34816-7.
  • Gogos A, Jimenez JC, Chang JC, Wilkening RV, Federle M. A Quorum Sensing-Regulated Protein Binds Cell Wall Components and Enhances Lysozyme Resistance in Streptococcus pyogenes.. Journal of bacteriology. 2018;200(11). doi:10.1128/JB.00701-17.
  • Pérez Morales TG, Ratia KM, Wang DS, Gogos A, Bloem L, Driver TG, Federle M. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO.. The Journal of biological chemistry. 2018;293(12):4580. doi:10.1074/jbc.AAC118.002674.
  • Cook LCC , Hu H, Maienschein-Cline M, Federle M. A Vaginal Tract Signal Detected by the Group B Streptococcus SaeRS System Elicits Transcriptomic Changes and Enhances Murine Colonization.. Infection and immunity. 2018;86(4). doi:10.1128/IAI.00762-17.
  • Pérez Morales TG, Ratia KM, Wang DS, Gogos A, Bloem L, Driver TG, Federle M. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO.. The Journal of biological chemistry. 2018;293(3):931-940. doi:10.1074/jbc.M117.810994.
  • Wilkening RV, Capodagli GC, Khataokar A, Tylor K, Neiditch MB, Federle M. Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond.. The Journal of biological chemistry. 2017;292(50):20544-20557. doi:10.1074/jbc.M117.801670.
  • Neiditch MB, Capodagli GC, Prehna G, Federle M. Genetic and Structural Analyses of RRNPP Intercellular Peptide Signaling of Gram-Positive Bacteria.. Annual review of genetics. 2017;51:311-333. doi:10.1146/annurev-genet-120116-023507.
  • Chen Z, Mashburn-Warren L, Merritt J, Federle M, Kreth J. Interference of a speB 5′ untranslated region partial deletion with mRNA degradation in Streptococcus pyogenes.. Molecular oral microbiology. 2017;32(5):390-403. doi:10.1111/omi.12181.
  • Wilkening RV, Federle M. Evolutionary Constraints Shaping Streptococcus pyogenes-Host Interactions.. Trends in microbiology. 2017;25(7):562-572. doi:10.1016/j.tim.2017.01.007.
  • Talagas A, Fontaine L, Ledesma-García L, Mignolet J, Li de la Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle M, Prehna G, Hols P, Nessler S. (2017). Correction: Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.. PLoS pathogens. Vol. 13. Issue 2. Page(s) e1006208.
  • Shanker EB, Federle M. Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans.. Genes. 2017;8(1). doi:10.3390/genes8010015.
  • Wilkening RV, Chang JC, Federle M. PepO, a CovRS-controlled endopeptidase, disrupts Streptococcus pyogenes quorum sensing. Mol Microbiol. 2016;99(1):71-87.
  • Chang JC, Federle M. PptAB Exports Rgg Quorum-Sensing Peptides in Streptococcus.. PloS one. 2016;11(12):e0168461. doi:10.1371/journal.pone.0168461.
  • Shanker EB, Morrison DA, Talagas A, Nessler S, Federle M, Prehna G. Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species.. PLoS pathogens. 2016;12(12):e1005979. doi:10.1371/journal.ppat.1005979.
  • Talagas A, Fontaine L, Ledesma-García L, Mignolet J, Li de la Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle M, Prehna G, Hols P, Nessler S. Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS.. PLoS pathogens. 2016;12(12):e1005980. doi:10.1371/journal.ppat.1005980.
  • Chang JC, Jimenez JC, Federle M. Induction of a quorum sensing pathway by environmental signals enhances group A streptococcal resistance to lysozyme. Mol Microbiol. 2015;97(6):1097-113.
  • Parashar V, Aggarwal C, Federle M, Neiditch MB. Rgg protein structure-function and inhibition by cyclic peptide compounds. Proc Natl Acad Sci U S A. 2015;112(16):5177-82.
  • Aggarwal CC, Jimenez Romaguera J, Lee HE, Chlipala G, Ratia K, Federle M. Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci.. mBio. 2015;6(3):e00393-15. doi:10.1128/mBio.00393-15.
  • Aggarwal C, Jimenez JC, Nanavati D, Federle M. Multiple length peptide-pheromone variants produced by Streptococcus pyogenes directly bind Rgg proteins to confer transcriptional regulation. J Biol Chem. 2014;289(32):22427-36.
  • Cook L, Federle M. Peptide pheromone signaling in Streptococcus and Enterococcus. FEMS Microbiol Rev. 2014;38(3):473-92.
  • Jimenez JC, Federle M. Quorum sensing in group A Streptococcus. Front Cell Infect Microbiol. 2014;4:127.
  • Marks LR, Mashburn-Warren L, Federle M, Hakansson AP. Streptococcus pyogenes biofilm growth in vitro and in vivo and its role in colonization, virulence, and genetic exchange. J Infect Dis. 2014;210(1):25-34.
  • Lasarre B, Aggarwal C, Federle M. Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes. MBio. 2013;3(6).
  • LaSarre B, Federle M. Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev. 2013;77(1):73-111.
  • Cook L, Lasarre B, Federle M. Interspecies Communication among Commensal and Pathogenic Streptococci. MBio. 2013;4(4).
  • Lasarre B, Chang JC, Federle M. Redundant group a streptococcus signaling peptides exhibit unique activation potentials. J Bacteriol. 2013;195(18):4310-8.
  • Buhrman JS, Cook L, Rayahin JE, Federle M, Gemeinhart RA. “Proteolytically activated anti-bacterial hydrogel microspheres”. Journal of Controlled Release. 2013;(171(3)):2882-2895. doi:10.1016/j.jconrel.2013.06.023.
  • Buhrman JS, Rayahin JE, Cook L, Federle M, Gemeinhart RA. “Active, soluble recombinant melittin purified by extracting insoluble lysate of Escherichia coli without denaturation”. Biotechnology Progress. 2013;(29(5)):1150-1157. doi:10.1002/btpr.1784.
  • Desai K, Mashburn-Warren L, Federle M, Morrison DA. Development of competence for genetic transformation of Streptococcus mutans in a chemically defined medium. J Bacteriol. 2012;194(15):3774-80.
  • Federle M. Pathogenic streptococci speak, but what are they saying?. Virulence. 2012;3(1):92-4.
  • Mashburn-Warren L, Morrison DA, Federle M. The cryptic competence pathway in Streptococcus pyogenes is controlled by a peptide pheromone. J Bacteriol. 2012;194(17):4589-600.
  • LaSarre B, Federle M. Regulation and consequence of serine catabolism in Streptococcus pyogenes. J Bacteriol. 2011;193(8):2002-12.
  • Chang JC, LaSarre B, Jimenez JC, Aggarwal C, Federle M. Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development. PLoS Pathog. 2011;7(8):e1002190.
  • Mashburn-Warren L, Morrison DA, Federle M. A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. Mol Microbiol. 2010;78(3):589-606.
  • Federle M. Autoinducer-2-based chemical communication in bacteria: complexities of interspecies signaling. Contrib Microbiol. 2009;16:18-32.
  • Neiditch MB, Federle M, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM. Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell. 2006;126(6):1095-108.
  • Neiditch MB, Federle M, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM. Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell. 2006;126(6):1095-108.
  • Semmelhack MF, Campagna SR, Federle M, Bassler BL. An expeditious synthesis of DPD and boron binding studies. Org Lett. 2005;7(4):569-72.
  • Neiditch MB, Federle M, Miller ST, Bassler BL, Hughson FM. Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Mol Cell. 2005;18(5):507-18.
  • Neiditch MB, Federle M, Miller ST, Bassler BL, Hughson FM. Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Mol Cell. 2005;18(5):507-18.
  • Semmelhack MF, Campagna SR, Hwa C, Federle M, Bassler BL. Boron binding with the quorum sensing signal AI-2 and analogues. Org Lett. 2004;6(15):2635-7.