Professor, College of Pharmacy - Medicinal Chemistry and Pharmacognosy
Director, Center for Biomolecular Sciences
Affiliate, Center for Biomolecular Sciences
About Heading link
I have spent over 25 years studying, researching, and mentoring in the field of molecular microbiology and bacterial pathogenesis. In 2008, I established an independent research laboratory at the University of Illinois at Chicago, focusing on chemical signaling in Gram-positive bacterial pathogens. My laboratory has helped to identify a widespread protein family characterized as cytoplasmic pheromone receptors. It is our mission to identify signaling pathways in Gram-positive pathogens (including Streptococcus pyogenes, S. pneumoniae, S. agalactiae, and S. mutans), characterize their benefits in bacterial survival or pathogenesis, and elucidate mechanisms of signaling interference as potential anti-virulence strategies. My training began at the University of Wisconsin, where I earned a bachelor’s degree in genetics. I spent three years working as a laboratory specialist in the labs of Dr. Frederick Blattner (Wisconsin, 2004-2005) and Dr. June R. Scott (Emory, 2005-2007). I completed my PhD in 2002 in the Microbiology and Molecular Genetics graduate program at Emory University under the mentorship of Dr. June Scott; my thesis was based on the characterization of the CovRS twocomponent signal transduction system in the human pathogen Streptococcus pyogenes. My postdoctoral training at Princeton University was under the mentorship of Dr. Bonnie Bassler. I helped to elucidate the molecular mechanism of autoinducer-2 sensory transduction through the LuxPQ receptor of Vibrio harveyi. Now, as a professor in the departments of Medicinal Chemistry and Pharmacognosy, and Microbiology and Immunology, I am the principle investigator of several research grants and lead a lab comprised of six graduate students and two postdoctoral scientists. I enjoy teaching to both graduate and professional students at UIC.
Teaching and Supervision Heading link
PSCI Ph.D. Thesis Research (PSCI 599), 5/16/2022 – 7/21/2022
PhD Thesis Research (MIM 599), 5/16/2022 – 7/21/2022
Microbial Pathogenesis (MIM 560), 3/15/2022 – Present
Topics in Biochemistry and Molecular Genetics (BCMG 575), 2/21/2022 – 2/25/2022
Grant Writing (MIM 594), 2/11/2022 – 4/4/2022
PHAR 423 (PHAR 423), 1/31/2022 – 2/10/2022
PSCI Ph.D. Thesis Research (PSCI 599), 1/10/2022 – 4/29/2022
PhD Thesis Research (MIM 599), 1/10/2022 – 4/29/2022
PHAR 502 (PHAR 502), 10/26/2021 – 11/8/2021
Macrophage Immunosuppression by Quorum-Induced Streptococcus pyogenes, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 7/1/2022 - 6/30/2026, Obligated Amount: $690493; Anticipated Amount: $2362683
Norway-India-Brazil-Canada-USA: Partnership for excellence in education, research and innovation in biofilm and antibiotic resistance, Univ of Oslo., 1/1/2021 - 12/31/2026, Obligated Amount: $33480; Anticipated Amount: $33480
Chemical profiling of bacterial-fungal interactions to elucidate mechanisms of growth and survival in multi-domain microbial communities, National Institutes of Health (National Center for Complementary and Integrative Health)., 1/1/2020 - 12/31/2020, Obligated Amount: $46016; Anticipated Amount: $46016
Transcriptomic and Genomic Differences of Group A Streptococcus in Humans: Acute Infection Versus Carriage, State University of New York - Binghampton., 7/10/2019 - 6/30/2022, Obligated Amount: $45843; Anticipated Amount: $45843
Novel Biofilm Inhibitors of Oral Streptococci, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 7/1/2019 - 6/30/2024, Obligated Amount: $553016; Anticipated Amount: $685330
Applying Ribo-Seq and RNA-Seq to identify quorum sensing pheromones and their regulons, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 2/19/2019 - 6/30/2022, Obligated Amount: $434568; Anticipated Amount: $434568
UIC Portal for Biomedical Research Careers (UIC PBRC) PREP, National Institutes of Health (National Institute of General Medical Sciences)., 1/1/2018 - 12/31/2022, Obligated Amount: $1409395; Anticipated Amount: $1512419
BWF Ad Hoc Grant ID# 1018487, Burroughs Wellcome Fund., 11/1/2017 - 10/31/2018, Obligated Amount: $1000; Anticipated Amount: $1000
Exploring the Role of a S. Pyogenes Quorum Sensing System on Adherence and Invasion of Tonsillar Epithelial Cells, American Medical Association., 4/1/2017 - 4/1/2017, Obligated Amount: $1973; Anticipated Amount: $1973
Chang, Jennifer C, Wilkening, Reid V, Rahbari, Kate M, Federle, Michael J. (2022). Quorum Sensing Regulation of a Major Facilitator Superfamily Transporter Affects Multiple Streptococcal Virulence Factors. Journal of Bacteriology, 204, (9), e00176-e00122. doi:10.1128/jb.00176-22.
Laczkovich, Irina, Mangano, Kyle, Shao, Xinhao, Hockenberry, Adam J, Gao, Yu, Mankin, Alexander, Vázquez-Laslop, Nora, Federle, Michael J. (2022). Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling. mBio, 13, (4), e01247-e01222. doi:10.1128/mbio.01247-22.
Kyono, Yasuhiro, Ellezian, Lori, Hu, YueYue, Eliadis, Kanella, Moy, Junlone, Hirsch, Elizabeth B, Federle, Michael J, Flowers, Stephanie A. (2022). The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of Bacteriology, 204, (5), e00102-e00122. doi:10.1128/jb.00102-22.
Rush, Jeffrey S, Parajuli, Prakash, Ruda, Alessandro, Li, Jian, Pohane, Amol Arunrao, Zamakhaeva, Svetlana, Rahman, Mohammad M, Chang, Jennifer C, Gogos, Artemis, Kenner, Cameron W, Lambeau, Gérard, Federle, Michael J, Korotkov, Konstantin V, Widmalm, Göran, Korotkova, Natalia. (2022). PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides. Nature Communications, 13, (1), 590. doi:10.1038/s41467-022-28257-0.
Woo, Jerry KK, McIver, Kevin S, Federle, Michael J. (2022). Carbon catabolite repression on the Rgg2/3 quorum sensing system in Streptococcus pyogenes is mediated by PTSMan and Mga. Molecular Microbiology, 117, (2), 525-538. doi:10.1111/mmi.14866.
Rued, Britta E, Covington, Brett C, Bushin, Leah B, Szewczyk, Gabriella, Laczkovich, Irina, Seyedsayamdost, Mohammad R, Federle, Michael J. (2021). Erratum for Rued et al., “Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound”. mBio, 12, (5), e02560-e02521. doi:10.1128/mbio.02560-21.
Rahbari, Kate M, Chang, Jennifer C, Federle, Michael J. (2021). A Streptococcus Quorum Sensing System Enables Suppression of Innate Immunity. mBio, 12, (3), e03400-e03420. doi:10.1128/mbio.03400-20.
Gogos, Artemis, Federle, Michael J. (2021). #99: Streptococcus pyogenes Utilizes the Peptide-Based Rgg 2/3 Quorum Sensing System During Oropharyngeal Colonization. Journal of the Pediatric Infectious Diseases Society, 10, (Supplement_1), s10-s10. doi:10.1093/jpids/piaa170.031.
Rued, Britta E, Covington, Brett C, Bushin, Leah B, Szewczyk, Gabriella, Laczkovich, Irina, Seyedsayamdost, Mohammad R, Federle, Michael J. (2021). Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound. mBio, 12, (2), e02688-e02620. doi:10.1128/mbio.02688-20.
Ad Hoc Reviewer, American Society for Microbiology, 3/31/2021 - Present
2020, ASM American Academy of Microbiology Fellow, American Society of Microbiology
Ph.D., Emory University, United States, 2002
B.S., University of Wisconsin–Madison, United States, 1994
Postdoctoral Research Fellow and Research Associate, Howard Hughes Medical Institute, United States, 2008