Selected Grants
Marine sponge depsipeptides to minimize antibiotic collateral damage, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 5/19/2023 - 4/30/2025, Obligated Amount: $439725; Anticipated Amount: $439725
Elucidating the role of an immunomodulator from a gut microbe in inflammatory bowel disease, National Institute of General Medical Sciences., 3/1/2018 - 5/31/2021, Obligated Amount: $185750; No Anticipated Amount Set
Selected Publications
Raherisoanjato, Jessia, Henke, Matthew T. (2023). Multi-arming ourselves against drug-resistant bacteria. Cell Host & Microbe, 31, (7), 1075-1076. doi:10.1016/j.chom.2023.06.011.
Vemulapalli, Vidyasiri, Donovan, Katherine A, Seegar, Tom CM, Rogers, Julia M, Bae, Munhyung, Lumpkin, Ryan J, Cao, Ruili, Henke, Matthew T, Ray, Soumya S, Fischer, Eric S, Cuny, Gregory D, Blacklow, Stephen C. (2021). Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry, 60, (34), 2593-2609. doi:10.1021/acs.biochem.1c00377.
Henke, Matthew T, Brown, Eric M, Cassilly, Chelsi D, Vlamakis, Hera, Xavier, Ramnik J, Clardy, Jon. (2021). Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus. Proceedings of the National Academy of Sciences of the United States of America, 118, (20), e2007595118. doi:10.1073/pnas.2007595118.
Chaudhari, Snehal N, Harris, David A, Aliakbarian, Hassan, Luo, James N, Henke, Matthew T, Subramaniam, Renuka, Vernon, Ashley H, Tavakkoli, Ali, Sheu, Eric G, Devlin, A Sloan. (2021). Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nature Chemical Biology, 17, (1), 20-29. doi:10.1038/s41589-020-0604-z.
Brugger, Silvio D, Eslami, Sara M, Pettigrew, Melinda M, Escapa, Isabel F, Henke, Matthew T, Kong, Yong, Lemon, Katherine P. (2020). Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota. mSphere, 5, (5), 10.1128/msphere.00852-10.1128/msphere.00820. doi:10.1128/msphere.00852-20.
Fukuda, Taise TH, Cassilly, Chelsi D, Gerdt, Joseph P, Henke, Matthew T, Helfrich, Eric JN, Mevers, Emily. (2020). Research Tales from the Clardy Laboratory: Function-Driven Natural Product Discovery. Journal of Natural Products, 83, (3), 744-755. doi:10.1021/acs.jnatprod.9b01086.
Henke, Matthew T, Clardy, Jon. (2019). Molecular messages in human microbiota. Science, 366, (6471), 1309-1310. doi:10.1126/science.aaz4164.
Mevers, Emily, Saurí, Josep, Helfrich, Eric JN, Henke, Matthew, Barns, Kenneth J, Bugni, Tim S, Andes, David, Currie, Cameron R, Clardy, Jon. (2019). Pyonitrins A–D: Chimeric Natural Products Produced by Pseudomonas protegens. Journal of the American Chemical Society, 141, (43), 17098-17101. doi:10.1021/jacs.9b09739.
Henke, Matthew T, Kenny, Douglas J, Cassilly, Chelsi D, Vlamakis, Hera, Xavier, Ramnik J, Clardy, Jon. (2019). Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide. Proceedings of the National Academy of Sciences of the United States of America, 116, (26), 12672-12677. doi:10.1073/pnas.1904099116.