Photo of Maria Barbolina

Maria Barbolina


Associate Professor, College of Pharmacy - Pharmaceutical Sciences

Email:

mvb@uic.edu

Related Sites:

About

Overview:
Our main research interests are centered on identifying and characterizing novel mechanisms regulating ovarian carcinoma metastasis. The goal of these studies is to identify novel drug-targetable vulnerabilities in ovarian carcinoma and to validate potential new drug targets in preclinical models of the disease. We combine a broad range of biochemical, cell and molecular biology assays, as well as animal models to address this unmet need. We are also interested in mechanisms regulating neurodegeneration and memory/learning. Mechanistic characterization of common molecular mechanisms governing neurodegeneration and cancer enables us to repurpose cancer drugs for neuroscience and vice versa.

Research Interests:
Mechanisms regulating metastatic ovarian carcinoma and neurodegeneration

Teaching Statement:
Tumor biology, endocrinology, pathophysiology of cancer, chemotherapy

Teaching and Supervision

Departmental Seminar (BPS 595), 8/23/2021 – 12/3/2021
Seminar in Med Chem (MDCH 595), 8/23/2021 – 12/3/2021
Seminar in Pharmacognosy (PMPG 595), 8/23/2021 – 12/3/2021
PDAT 5: Cardiovascular (PHAR 505), 6/14/2021 – 8/20/2021
PDAT 5: Cardiovascular (PHAR 505), 6/14/2021 – 8/20/2021
PSCI 592 Lab Rotation, 3/25/2021 – 5/7/2021
Pathophysiology, Drug Action, & Therapeutics (PDAT) 9: Hematology/Oncology (PHAR 509), 1/11/2021 – 5/3/2021
PDAT 5: Cardiovascular (PHAR 505), 1/11/2021 – 4/30/2021
PDAT 5: Cardiovascular (PHAR 505), 1/11/2021 – 4/30/2021

Selected Grants

Neuronal excitability and copy number variation disorders, Northwestern University., 9/1/2020 - 5/31/2022, Obligated Amount: $267618; Anticipated Amount: $267618

Targeting Microtubule Associated Protein Tau in Ovarian Carcinoma to Increase Efficacy of Paclitaxel, National Institutes of Health (National Cancer Institute)., 7/1/2019 - 6/30/2022, Obligated Amount: $377349; Anticipated Amount: $377349

Targeting Fractalkine Receptor to Increase Sensitivity to PARP inhibitors, Tell Every Amazing Lady About Ovarian Cancer Louisa M McGregor Ovarian Cancer Foundation (TEAL)., 9/1/2017 - 1/31/2019, Obligated Amount: $35000; Anticipated Amount: $35000

Synaptic and Dendritic Dysfunction in Psychiatric Disorders, Northwestern University., 8/1/2017 - 4/30/2022, Obligated Amount: $331438; Anticipated Amount: $331438

Impact of the Ovarian Microenvironment on Serious Cancer, US Department of Defense., 8/1/2014 - 7/31/2017, Obligated Amount: $472201; Anticipated Amount: $472201

Chemokine- Dependent Control of Survival in Ovarian Carcinoma, Ovarian Cancer Research Alliance., 2/1/2013 - 1/31/2017, Obligated Amount: $450000; Anticipated Amount: $450000

Functional Role Of The Fractaline Signaling In Epithelial Ovarian Carcinoma, National Institutes of Health (National Cancer Institute)., 8/1/2011 - 7/31/2014, Obligated Amount: $371217; Anticipated Amount: $371217

Function Of Lymphotactin Receptor-Ligand Interaction In Ovarian Carcinoma, Amer Cancer Soc (IL Div)., 6/1/2011 - 5/31/2013, Obligated Amount: $100000; Anticipated Amount: $100000

Selected Publications

Barbolina, MV. (2021). Dichotomous role of microtubule associated protein tau as a biomarker of response to and a target for increasing efficacy of taxane treatment in cancers of epithelial origin. Pharmacological Research, 168. doi:10.1016/j.phrs.2021.105585.

Suarez, JS, Main, HG, Muralidhar, GG, Elfituri, O, Xu, HL, Kajdacsy-Balla, AA, Barbolina, MV. (2019). CD44 regulates formation of spheroids and controls organ-specific metastatic colonization in epithelial ovarian carcinoma. Molecular Cancer Research, 17, (9), 1801-1814. doi:10.1158/1541-7786.MCR-18-1205.

Barbolina, MV. (2018). Molecular mechanisms regulating organ-specific metastases in epithelial ovarian carcinoma. Cancers, 10, (11). doi:10.3390/cancers10110444.

Barbolina, MV, Kulikova, VV, Tsvetikova, MA, Anufrieva, NV, Revtovich, SV, Phillips, RS, Gollnick, PD, Demidkina, TV, Faleev, NG. (2018). Serine 51 residue of Citrobacter freundii tyrosine phenol-lyase assists in C-α-proton abstraction and transfer in the reaction with substrate. Biochimie, 147, 63-69. doi:10.1016/j.biochi.2017.11.016.

Xie, J, Gurler Main, H, Sacks, JD, Muralidhar, GG, Barbolina, MV. (2018). Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma/631/67/631/67/1517/1709/13/1/96/106/96/109/96/95/96/63 article. Oncogenesis, 7, (4). doi:10.1038/s41389-018-0046-6.

Gurler Main, H, Xie, J, Muralidhar, GG, Elfituri, O, Xu, H, Kajdacsy-Balla, AA, Barbolina, MV. (2017). Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma. Oncogene, 36, (21), 3025-3036. doi:10.1038/onc.2016.456.

Gurler, H, Macias, V, Kajdacsy-Balla, AA, Barbolina, MV. (2015). Examination of the fractalkine and fractalkine receptor expression in fallopian adenocarcinoma reveals differences when compared to ovarian carcinoma. Biomolecules, 5, (4), 3438-3447. doi:10.3390/biom5043438.

Sacks, JD, Barbolina, MV. (2015). Expression and function of CD44 in epithelial ovarian carcinoma. Biomolecules, 5, (4), 3051-3066. doi:10.3390/biom5043051.

Muralidhar, GG, Barbolina, MV. (2015). The miR-200 family: Versatile players in epithelial ovarian cancer. International Journal of Molecular Sciences, 16, (8), 16833-16847. doi:10.3390/ijms160816833.

Professional Leadership

Midtenure review, 2/1/2019 - 3/10/2019

Notable Honors

2013, Liz Tilberis Scholar Award, Ovarian Cancer Research Foundation

2010, Hans W. Valteich Research Scholar Award, College of Pharmacy

Education

Degrees:
Ph.D, Engelhardt Institute of Molecular Biology, Russia, 2001
M.S., Moscow State University of Fine Chemical Technologies, Russia, 1996

Postgraduate Training:
Postdoctoral Fellow, Northwestern University, United States, 2008
Postdoctoral Fellow, Northwestern University, United States, 2006
Postdoctoral Fellow, State University of New York at Buffalo, United States, 2004