Photo of Maria  Barbolina

Maria Barbolina

Associate Professor, Biopharmaceutical Sciences



833 South Wood Street; Room 453, Chicago, IL, 60612

Office Phone:

(312) 335-0670

Office Phone TTY:

(312) 996-0098


Office Phone:

(312) 335-5487


Microenvironmental Regulation of Ovarian Carcinoma Metastasis.

Signal Transduction Pathways.

Mechanisms of Chemoresistance

Selected Publications

  • Barbolina MV. Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma.. Cancers. 2018;.
  • Xie J, Gurler Main H, Sacks JD, Muralidhar GG, Barbolina MV. Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma.. Oncogenesis. 2018;.
  • Barbolina MV, Kulikova VV, Tsvetikova MA, Anufrieva NV, Revtovich SV, Phillips RS, Gollnick PD, Demidkina TV, Faleev NG. Serine 51 residue of Citrobacter freundii tyrosine phenol-lyase assists in C-α-proton abstraction and transfer in the reaction with substrate.. Biochimie. 2018;.
  • Gurler Main H, Xie J, Muralidhar G, Elfituri O, Xu H, Kajdacsy-Balla AA, Barbolina M. Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma.. Oncogene. 2017;. doi:10.1038/onc.2016.456.
  • Gurler H, Macias V, Kajdacsy-Balla AA, Barbolina M. Examination of the Fractalkine and Fractalkine Receptor Expression in Fallopian Adenocarcinoma Reveals Differences When Compared to Ovarian Carcinoma.. Biomolecules. 2015;5(4):3438-47. doi:10.3390/biom5043438.
  • Sacks JD, Barbolina M. Expression and Function of CD44 in Epithelial Ovarian Carcinoma.. Biomolecules. 2015;5(4):3051-66. doi:10.3390/biom5043051.
  • Mitra AK, Davis DA, Tomar S, Roy L, Gurler H, Xie J, Lantvit DD, Cardenas H, Fang F, Liu Y, Loughran E, Yang J, Sharon Stack M, Emerson RE, Cowden Dahl KD, Barbolina M, Nephew KP, Matei D, Burdette JE. In vivo tumor growth of high-grade serous ovarian cancer cell lines.. Gynecologic oncology. 2015;138(2):372-7. doi:10.1016/j.ygyno.2015.05.040.
  • Muralidhar G, Barbolina M. The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer.. International journal of molecular sciences. 2015;16(8):16833-47. doi:10.3390/ijms160816833.
  • Gurler H, Yu Y, Choi J, Kajdacsy-Balla AA, Barbolina M. Three-dimensional collagen type I matrix up-regulates nuclear isoforms of the microtubule associated protein tau implicated in resistance to paclitaxel therapy in ovarian carcinoma.. International journal of molecular sciences. 2015;16(2):3419-33. doi:10.3390/ijms16023419.
  • Desjardins M, Xie J, Gurler H, Muralidhar GD, Sacks JE, Burdette J, Barbolina M. Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids.. Journal of ovarian research. 2014;7:70. doi:10.1186/1757-2215-7-70.
  • Muralidhar G, Barbolina M. Chemokine receptors in epithelial ovarian cancer.. International journal of molecular sciences. 2013;15(1):361-76. doi:10.3390/ijms15010361.
  • Rooper L, Gurler H, Kajdacsy-Balla AA, Barbolina M. Fractalkine receptor is expressed in mature ovarian teratomas and required for epidermal lineage differentiation.. Journal of ovarian research. 2013;6(1):57. doi:10.1186/1757-2215-6-57.
  • Barbolina M, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS. Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.. The Journal of biological chemistry. 2013;288(1):141-51. doi:10.1074/jbc.M112.431411.
  • Kim M, Rooper LE, Xie JE, Rayahin JA, Burdette J, Kajdacsy-Balla A, Barbolina M. The lymphotactin receptor is expressed in epithelial ovarian carcinoma and contributes to cell migration and proliferation.. Molecular cancer research : MCR. 2012;10(11):1419-29. doi:10.1158/1541-7786.MCR-12-0361.
  • Kim M, Rooper L, Xie J, Kajdacsy-Balla AA, Barbolina M. Fractalkine receptor CX(3)CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells.. Molecular cancer research : MCR. 2012;10(1):11-24. doi:10.1158/1541-7786.MCR-11-0256.
  • Barbolina M, Burkhalter RJ, Stack MS. Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment.. The Biochemical journal. 2011;437(1):1-12. doi:10.1042/BJ20110112.
  • Bellis AD, Peňalver-Bernabé B, Weiss MS, Yarrington ME, Barbolina M, Pannier AK, Jeruss JS, Broadbelt LJ, Shea LD. Cellular arrays for large-scale analysis of transcription factor activity.. Biotechnology and bioengineering. 2011;108(2):395-403. doi:10.1002/bit.22916.
  • Barbolina M, Kim M, Liu Y, Shepard J, Belmadani A, Miller RJ, Shea LD, Stack MS. Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma.. Molecular cancer research : MCR. 2010;8(5):653-64. doi:10.1158/1541-7786.MCR-09-0463.
  • Woolfrey KM, Srivastava DP, Photowala H, Yamashita M, Barbolina M, Cahill ME, Xie Z, Jones KA, Quilliam LA, Prakriya M, Penzes P. Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines.. Nature neuroscience. 2009;12(10):1275-84. doi:10.1038/nn.2386.
  • Moss NM, Barbolina M, Liu Y, Sun L, Munshi HG, Stack MS. Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination.. Cancer research. 2009;69(17):7121-9. doi:10.1158/0008-5472.CAN-08-4151.
  • Barbolina M, Adley BP, Kelly DL, Shepard J, Fought AJ, Scholtens D, Penzes P, Shea LD, Stack MS. Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion.. International journal of cancer. Journal international du cancer. 2009;125(4):816-25. doi:10.1002/ijc.24347.
  • Cahill ME, Xie Z, Day M, Photowala H, Barbolina M, Miller CA, Weiss C, Radulovic J, Sweatt JD, Disterhoft JF, Surmeier DJ, Penzes P. Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(31):13058-63. doi:10.1073/pnas.0904636106.
  • Barbolina M, Moss NM, Westfall SD, Liu Y, Burkhalter RJ, Marga F, Forgacs G, Hudson LG, Stack MS. Microenvironmental regulation of ovarian cancer metastasis.. Cancer treatment and research. 2009;149:319-34. doi:10.1007/978-0-387-98094-2_15.
  • Barbolina M, Adley BP, Kelly DL, Fought AJ, Scholtens DM, Shea LD, Stack MS. Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma.. Laboratory investigation; a journal of technical methods and pathology. 2008;88(6):602-14. doi:10.1038/labinvest.2008.25.
  • Barbolina M, Adley BP, Shea LD, Stack MS. Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion.. Cancer. 2008;112(7):1632-41. doi:10.1002/cncr.23341.
  • Barbolina M, Stack MS. Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis.. Seminars in cell & developmental biology. 2008;19(1):24-33. doi:10.1016/j.semcdb.2007.06.008.
  • Barbolina M, Kristoforov R, Manfredo A, Chen Y, Gollnick P. The rate of TRAP binding to RNA is crucial for transcription attenuation control of the B. subtilis trp operon.. Journal of molecular biology. 2007;370(5):925-38. doi:10.1016/j.jmb.2007.05.027.
  • Barbolina M, Adley BP, Ariztia EV, Liu Y, Stack MS. Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression.. The Journal of biological chemistry. 2007;282(7):4924-31. doi:10.1074/jbc.M608428200.
  • Barbolina M, Li X, Gollnick P. Bacillus subtilis TRAP binds to its RNA target by a 5′ to 3′ directional mechanism.. Journal of molecular biology. 2005;345(4):667-79. doi:10.1016/j.jmb.2004.10.071.
  • Demidkina TV, Barbolina M, Faleev NG, Sundararaju B, Gollnick PD, Phillips RS. Threonine-124 and phenylalanine-448 in Citrobacter freundii tyrosine phenol-lyase are necessary for activity with L-tyrosine.. The Biochemical journal. 2002;363(Pt 3):745-52.
  • Faleev NG, Zhukov YN, Khurs EN, Gogoleva OI, Barbolina M, Bazhulina NP, Belikov VM, Demidkina TV, Khomutov RM. Interaction of tyrosine phenol-lyase with phosphoroorganic analogues of substrate amino acids.. European journal of biochemistry / FEBS. 2000;267(23):6897-902.
  • Barbolina M, Phillips RS, Gollnick PD, Faleev NG, Demidkina TV. Citrobacter freundii tyrosine phenol-lyase: the role of asparagine 185 in modulating enzyme function through stabilization of a quinonoid intermediate.. Protein engineering. 2000;13(3):207-15.
  • Sundararaju B, Antson AA, Phillips RS, Demidkina TV, Barbolina M, Gollnick P, Dodson GG, Wilson KS. The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4′-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity.. Biochemistry. 1997;36(21):6502-10. doi:10.1021/bi962917+.
  • Education

  • PhD, , Russian Academy of Sciences,
  • BS, , Lomonosov Moscow State Academy of Fine Chemical Technology,