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Photo of Nancy E. Freitag

Nancy E. Freitag


Professor and Head, College of Pharmacy, Pharmaceutical Sciences
Professor, College of Medicine - Microbiology and Immunology

Contact

Address:

833 S. Wood St., Chicago, Illinois

Related Sites:

Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 8/21/2023 – 12/1/2023
PhD Thesis Research (MIM 599), 8/21/2023 – 12/1/2023
PSCI Ph.D. Thesis Research (PSCI 599), 6/12/2023 – 8/4/2023
PhD Thesis Research (MIM 599), 5/15/2023 – 8/4/2023
PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
Undergrad Res Exp Pharm Sci (PSCI 300), 1/9/2023 – 4/28/2023
PhD Thesis Research (MIM 599), 1/9/2023 – 4/28/2023
PhD Thesis Research (MIM 599), 8/22/2022 – 12/2/2022
Biochemistry (GEMS 501), 8/22/2022 – 12/2/2022

Selected Grants

Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 8/1/2023 - 7/31/2025, Obligated Amount: $111701; Anticipated Amount: $223402

2022 International Conference on Gram Positive Pathogens, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 9/1/2022 - 8/31/2023, Obligated Amount: $7000; Anticipated Amount: $7000

Deciphering mechanisms of Listeria placental-fetal invasion, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 6/15/2022 - 5/31/2027, Obligated Amount: $956155; Anticipated Amount: $2440357

Deciphering the impact of sedative choice on the dynamics of Klebsiella pneumoniae lung infection, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 11/16/2021 - 10/31/2023, Obligated Amount: $449200; Anticipated Amount: $449200

Deciphering mechanisms of Listeria placental-fetal invasion, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 7/14/2021 - 6/30/2022, Obligated Amount: $391795; Anticipated Amount: $391795

Role of Regulatory T Cells in Preventing Autoimmunity during Infection, Chicago Biomedical Consortium., 9/1/2019 - 8/31/2021, Obligated Amount: $80000; Anticipated Amount: $80000

Deciphering Mechanisms of Listeria Placental-Fetal Invasion, National Institutes of Health (Eunice Kennedy Shriver National Institute of Child Health and Human Development)., 8/17/2017 - 7/31/2019, Obligated Amount: $439725; Anticipated Amount: $439725

Characterization of Pneumococcal Secretion Chaperones Required for Virulence, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 7/1/2017 - 11/30/2019, Obligated Amount: $250884; Anticipated Amount: $250884

Post-Translation Regulation of Listeria Monocytogenes Virulence Factors (2 RO1 A10832141), National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 8/15/2016 - 7/31/2021, Obligated Amount: $1778855; Anticipated Amount: $1778855

Selected Publications

Taylor, Diandra M Vaval, Xayarath, Bobbi, Freitag, Nancy E. (2023). Two Permeases Associated with the Multifunctional CtaP Cysteine Transport System in Listeria monocytogenes Play Distinct Roles in Pathogenesis. Microbiology Spectrum, 11, (3), e03317-e03322. doi:10.1128/spectrum.03317-22.

Cahoon, Laty A, Alejandro‐Navarreto, Xiomarie, Gururaja, Avinash N, Light, Sam H, Alonzo, Francis, Anderson, Wayne F, Freitag, Nancy E. (2022). Listeria monocytogenes two component system PieRS regulates secretion chaperones PrsA1 and PrsA2 and enhances bacterial translocation across the intestine. Molecular Microbiology, 118, (3), 278-293. doi:10.1111/mmi.14967.

Mains, David R, Eallonardo, Samuel J, Freitag, Nancy E. (2021). Identification of Listeria monocytogenes Genes Contributing to Oxidative Stress Resistance under Conditions Relevant to Host Infection.. Infection and Immunity, 89, (4). doi:10.1128/iai.00700-20.

Lamond, Nicole M, McMullen, P David, Paramasvaran, Dhanendra, Visvahabrathy, Lavanya, Eallonardo, Samuel J, Maheswhari, Akhil, Freitag, Nancy E. (2021). Cardiotropic Isolates of Listeria monocytogenes with Enhanced Vertical Transmission Dependent upon the Bacterial Surface Protein InlB.. Infection and Immunity, 89, (2). doi:10.1128/iai.00321-20.

Ignatov, Dmitriy, Vaitkevicius, Karolis, Durand, Sylvain, Cahoon, Laty, Sandberg, Stefanie S, Liu, Xijia, Kallipolitis, Birgitte H, Rydén, Patrik, Freitag, Nancy, Condon, Ciarán, Johansson, Jörgen. (2020). An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes. Cell Reports, 30, (12), 4027-4040.e7. doi:10.1016/j.celrep.2020.03.006.

Farizano, Juan V, Masías, Emilse, Hsu, Fong-Fu, Salomón, Raúl A, Freitag, Nancy E, Hebert, Elvira María, Minahk, Carlos, Saavedra, Lucila. (2019). Corrigendum to “PrfA activation in Listeria monocytogenes increases the sensitivity to class IIa bacteriocins despite impaired expression of the bacteriocin receptor” BBAGEN 2019 Aug 1863/8 Page 1283–1291. Biochimica et Biophysica Acta (BBA) – General Subjects, 1863, (11), 129404. doi:10.1016/j.bbagen.2019.07.013.

Johansson, Jörgen, Freitag, Nancy E. (2019). Regulation of Listeria monocytogenes Virulence. Gram-Positive Pathogens. (pp. 836-850). American Society for Microbiology. doi:10.1128/9781683670131.ch52.

Farizano, Juan V, Masías, Emilse, Hsu, Fong-Fu, Salomón, Raúl A, Freitag, Nancy E, Hebert, Elvira María, Minahk, Carlos, Saavedra, Lucila. (2019). PrfA activation in Listeria monocytogenes increases the sensitivity to class IIa bacteriocins despite impaired expression of the bacteriocin receptor. Biochimica et Biophysica Acta (BBA) – General Subjects, 1863, (8), 1283-1291. doi:10.1016/j.bbagen.2019.04.021.

Johansson, Jörgen, Freitag, Nancy E. (2019). Regulation of Listeria monocytogenes Virulence.. Microbiology Spectrum, 7, (4). doi:10.1128/microbiolspec.gpp3-0064-2019.

Professional Leadership

American Academy of Microbiology Election Committee, American Soceity of Microbiology, 5/1/2017 - 7/1/2021

American Academy of Microbiologists Elections Committee, American Academy of Microbiologists, 2017 - 2021

Scientific Review Board, 2015 - 2018

International Conference on Gram Positive Pathogens Organizing Committee, 10/2012 - 10/2012

General Meeting, American Society for Microbiology, 5/2011 - 5/2011

Notable Honors

2017, Bridge to the Doctorate Faculty Mentor of the Year, University of Illinois at Chicago

2017, M2 Medical Student Golden Apple Teaching Award, University of Illinois at Chicago

2017, Executive Leadership in Academic Medicine (ELAM) Fellow,

2017, University Scholar, University of Illinois at Chicago

2016, Fellow, American Academy of Microbiology

2015, Medical Student Class of 2015 selected Faculty Graduation Hooder, University of Illinois at Chicago

2014, Faculty of the Year Award, University of Illinois at Chicago

2014, M2 Medical Student Golden Apple Teaching Award, University of Illinois at Chicago

2013, M2 Medical Student Golden Apple Teaching Award, University of Illinois at Chicago

Education

Degrees:
Ph.D., University of California Los Angeles, United States, 1989
B.S., University of California, Irvine, United States, 1984