Nora C. Vazquez-Laslop
Research Professor, College of Pharmacy- Center for Biomolecular Sciences
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Teaching and Supervision Heading link
Biochemistry (GEMS 501), 8/22/2022 – 12/2/2022
Molecular Biology (GEMS 502), 8/22/2022 – 12/2/2022
Cell Biology (GEMS 503), 8/22/2022 – 12/2/2022
Critical thinking, Prep Scholars, 4/2022 – 4/2022
Topics in Biochem and Mol Genetics (BCMG 575), 2/14/2022 – 2/18/2022
GEMS Cell Biology, 9/13/2021 – Present
Biochemistry (GEMS 501), 8/23/2021 – 12/3/2021
Molecular Biology (GEMS 502), 8/23/2021 – 12/3/2021
Cell Biology (GEMS 503), 8/23/2021 – 12/3/2021
Selected Grants
Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 8/1/2023 - 7/31/2025, Obligated Amount: $111701; Anticipated Amount: $223402
Antibiotics targeting translation, McMaster University., 6/1/2023 - 11/30/2023, Obligated Amount: $50000; Anticipated Amount: $50000
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 7/16/2021 - 2/7/2022, Obligated Amount: $730027; Anticipated Amount: $730027
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 7/16/2021 - 2/7/2022, Obligated Amount: $730027; Anticipated Amount: $730027
Control of translation by the nascent protein after its full synthesis and release, National Science Foundation., 3/15/2020 - 2/29/2024, Obligated Amount: $1000000; Anticipated Amount: $1000000
Control of translation by the nascent protein after its full synthesis and release, Directorate for Biological Sciences., 3/15/2020 - 2/29/2024, Obligated Amount: $1000000; No Anticipated Amount Set
Optimizing E. coli for expressing therapeutical protein, Molecular Templates., 12/12/2019 - 12/11/2020, Obligated Amount: $10523; Anticipated Amount: $10523
Selected Publications
Vázquez-Laslop, Nora, Polikanov, Yury S. (2023). Motif-ation matters. Nature Chemical Biology, 19, (9), 1044-1045. doi:10.1038/s41589-023-01365-8.
Mangano, Kyle, Klepacki, Dorota, Ohanmu, Irueosa, Baliga, Chetana, Huang, Weiping, Brakel, Alexandra, Krizsan, Andor, Polikanov, Yury S, Hoffmann, Ralf, Vázquez-Laslop, Nora, Mankin, Alexander S. (2023). Inhibition of translation termination by the antimicrobial peptide Drosocin. Nature Chemical Biology, 19, (9), 1082-1090. doi:10.1038/s41589-023-01300-x.
Mangano, Kyle, Marks, James, Klepacki, Dorota, Saha, Chayan Kumar, Atkinson, Gemma C, Vázquez-Laslop, Nora, Mankin, Alexander S. (2022). Context-based sensing of orthosomycin antibiotics by the translating ribosome. Nature Chemical Biology, 18, (11), 1277-1286. doi:10.1038/s41589-022-01138-9.
Meydan, Sezen, Klepacki, Dorota, Karthikeyan, Subbulakshmi, Margus, Tõnu, Thomas, Paul, Jones, John E, Khan, Yousuf A, Briggs, Joseph, Dinman, Jonathan D, Vázquez-Laslop, Nora, Mankin, Alexander S. (2022). Response to: Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding. Molecular Cell, 82, (19), 3523. doi:10.1016/j.molcel.2022.08.025.
Laczkovich, Irina, Mangano, Kyle, Shao, Xinhao, Hockenberry, Adam J, Gao, Yu, Mankin, Alexander, Vázquez-Laslop, Nora, Federle, Michael J. (2022). Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling. mBio, 13, (4), e01247-e01222. doi:10.1128/mbio.01247-22.
Tsai, Kaitlyn, Stojković, Vanja, Lee, D John, Young, Iris D, Szal, Teresa, Klepacki, Dorota, Vázquez-Laslop, Nora, Mankin, Alexander S, Fraser, James S, Fujimori, Danica Galonić. (2022). Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nature Structural & Molecular Biology, 29, (2), 162-171. doi:10.1038/s41594-022-00723-9.
Syroegin, Egor A, Flemmich, Laurin, Klepacki, Dorota, Vazquez-Laslop, Nora, Micura, Ronald, Polikanov, Yury S. (2022). Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nature Structural & Molecular Biology, 29, (2), 152-161. doi:10.1038/s41594-022-00720-y.
Zhang, Yan, Aleksashin, Nikolay A, Klepacki, Dorota, Anderson, Caleb, Vázquez-Laslop, Nora, Gross, Carol A, Mankin, Alexander S. (2022). The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation. Proceedings of the National Academy of Sciences of the United States of America, 119, (4), e2118553119. doi:10.1073/pnas.2118553119.
Vazquez-Laslop, Nora, Sharma, Cynthia M, Mankin, Alexander, Buskirk, Allen R. (2022). Identifying Small Open Reading Frames in Prokaryotes with Ribosome Profiling. Journal of Bacteriology, 204, (1), e00294-e00221. doi:10.1128/jb.00294-21.
Education
Degrees:
B.S., Universidad Nacional Autonoma de Mexico, Mexico, 1986
M.Sci., Universidad Nacional Autonoma de Mexico, Mexico, 1990
Ph.D., Universidad Nacional Autonoma de Mexico, Mexico, 1990