Nora C. Vazquez-Laslop
Research Professor, College of Pharmacy- Center for Biomolecular Sciences
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About
Teaching and Supervision
From RNA to Protein in Prokaryotes (Foundations of Biomedical Science I), 9/11/2023 – 9/15/2023
BCMG 575: Topics in Biochemistry and Molecular Genetics, 2/13/2023 – 2/17/2023
Bacterial Toxins and effector proteins (MIM 560: Microbial Pathogensis), 1/24/2023 – Present
Biochemistry (GEMS 501), 8/22/2022 – 12/2/2022
Molecular Biology (GEMS 502), 8/22/2022 – 12/2/2022
Cell Biology (GEMS 503), 8/22/2022 – 12/2/2022
Critical thinking, Prep Scholars, 4/2022 – 4/2022
Topics in Biochem and Mol Genetics (BCMG 575), 2/14/2022 – 2/18/2022
GEMS Cell Biology, 9/13/2021 – Present
Selected Grants
Elucidating the role of peptidyl-tRNA hydrolase activities in translation regulation, National Science Foundation., 3/1/2024 - 2/29/2028, Obligated Amount: $1200000; Anticipated Amount: $1200000
UIC Portal to Biomedical Research Careers (UIC PBRC) PREP, National Institutes of Health (National Institute of General Medical Sciences)., 2/1/2024 - 1/31/2025, Obligated Amount: $415994; Anticipated Amount: $2079970
Unraveling context specificity of translation by elucidating the mechanism of action of auxiliary translation factors, National Institutes of Health., 12/1/2023 - Present, No Obligated Amount Set; Anticipated Amount: $3175340
Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 8/1/2023 - 7/31/2025, Obligated Amount: $111701; Anticipated Amount: $223402
Antibiotics targeting translation, McMaster University., 6/1/2023 - 11/30/2023, Obligated Amount: $50000; Anticipated Amount: $50000
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 7/16/2021 - 2/7/2022, Obligated Amount: $730027; Anticipated Amount: $730027
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 7/16/2021 - 2/7/2022, Obligated Amount: $730027; Anticipated Amount: $730027
Selected Publications
Aleksandrova, Elena V, Ma, Cong-Xuan, Klepacki, Dorota, Alizadeh, Faezeh, Vázquez-Laslop, Nora, Liang, Jian-Hua, Polikanov, Yury S, Mankin, Alexander S. (2024). Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. Nature Chemical Biology, 20, (12), 1680-1690. doi:10.1038/s41589-024-01685-3.
Huang, Weiping, Baliga, Chetana, Aleksandrova, Elena V, Atkinson, Gemma, Polikanov, Yury S, Vázquez-Laslop, Nora, Mankin, Alexander S. (2024). Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects. EMBO Reports, 25, (11), 5194-5211. doi:10.1038/s44319-024-00277-5.
Huang, Weiping, Baliga, Chetana, Vázquez-Laslop, Nora, Mankin, Alexander S. (2024). Sequence diversity of apidaecin-like peptides arresting the terminating ribosome. Nucleic Acids Research, 52, (15), 8967-8978. doi:10.1093/nar/gkae567.
Judd, Heather NG, Martínez, Allyson K, Klepacki, Dorota, Vázquez-Laslop, Nora, Sachs, Matthew S, Cruz-Vera, Luis R. (2024). Functional domains of a ribosome arresting peptide are affected by surrounding nonconserved residues. Journal of Biological Chemistry, 300, (3), 105780. doi:10.1016/j.jbc.2024.105780.
Svetlov, Maxim S, Dunand, Clémence F, Nakamoto, Jose A, Atkinson, Gemma C, Safdari, Haaris A, Wilson, Daniel N, Vázquez-Laslop, Nora, Mankin, Alexander S. (2024). Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated quality control. Molecular Cell, 84, (4), 715-726.e5. doi:10.1016/j.molcel.2023.12.002.
Vázquez-Laslop, Nora, Polikanov, Yury S. (2023). Motif-ation matters. Nature Chemical Biology, 19, (9), 1044-1045. doi:10.1038/s41589-023-01365-8.
Mangano, Kyle, Klepacki, Dorota, Ohanmu, Irueosa, Baliga, Chetana, Huang, Weiping, Brakel, Alexandra, Krizsan, Andor, Polikanov, Yury S, Hoffmann, Ralf, Vázquez-Laslop, Nora, Mankin, Alexander S. (2023). Inhibition of translation termination by the antimicrobial peptide Drosocin. Nature Chemical Biology, 19, (9), 1082-1090. doi:10.1038/s41589-023-01300-x.
Mangano, Kyle, Marks, James, Klepacki, Dorota, Saha, Chayan Kumar, Atkinson, Gemma C, Vázquez-Laslop, Nora, Mankin, Alexander S. (2022). Context-based sensing of orthosomycin antibiotics by the translating ribosome. Nature Chemical Biology, 18, (11), 1277-1286. doi:10.1038/s41589-022-01138-9.
Meydan, Sezen, Klepacki, Dorota, Karthikeyan, Subbulakshmi, Margus, Tõnu, Thomas, Paul, Jones, John E, Khan, Yousuf A, Briggs, Joseph, Dinman, Jonathan D, Vázquez-Laslop, Nora, Mankin, Alexander S. (2022). Response to: Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding. Molecular Cell, 82, (19), 3523. doi:10.1016/j.molcel.2022.08.025.
Education
Degrees:
B.S., Universidad Nacional Autonoma de Mexico, Mexico, 1986
M.Sci., Universidad Nacional Autonoma de Mexico, Mexico, 1990
Ph.D., Universidad Nacional Autonoma de Mexico, Mexico, 1990