Photo of Jimmy Orjala

Jimmy Orjala


Director of Graduate Studies for Pharmacognosy graduate program, College of Pharmacy - Pharmaceutical Sciences
Professor, College of Pharmacy

Contact

Address:

900 South Ashland Avenue, Chicago, IL

Office Phone:

(312) 996-5583 (work)

Related Sites:

About

Research Interests:
1. Discovery, isolation, and structure elucidation of biological active metabolites from cultured cyanobacteria.
2. Application of sensitive analytical techniques to the structure elucidation and biological characterization of natural products.

Teaching and Supervision

PDAT 2: GI/Endocrine (PHAR 502), 1/11/2021 – 4/30/2021
PDAT 5: Cardiovascular, 1/11/2021 – 5/7/2021
STRUCTURAL ELUCIDATION OF NATURAL PRODUCTS (PSCI 521), 1/11/2021 – 5/7/2021
Pharmacog Research Techniques (PSCI 520), 8/24/2020 – 12/4/2020
PDAT 4: Immunology, 8/24/2020 – 12/4/2020
PDAT 2: GI/Endocrine (PHAR 502), 1/13/2020 – 5/1/2020
PMPG 511 Advance Pharmacognosy, 1/13/2020 – 5/1/2020
PDAT 5: Cardiovascular (PHAR 505), 1/13/2020 – 5/8/2020

Selected Grants

Discovery of Anticancer Agents of Diverse Natural Origin, Ohio State University., 5/15/2020 - 4/30/2022, Obligated Amount: $674076; Anticipated Amount: $674076

Role of a conserved gene cluster family in promoting motility behavior in proteobacteria and in mediating host interactions, National Science Foundation., 8/15/2019 - 7/31/2022, Obligated Amount: $546571; Anticipated Amount: $546571

Research Training in Natural Product Complementary and Integrative Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 1/1/2019 - 12/31/2023, Obligated Amount: $878121; Anticipated Amount: $2100520

Selected Publications

Ióca, LP, Dai, Y, Kunakom, S, Diaz-Espinosa, J, Krunic, A, Crnkovic, CM, Orjala, J, Sanchez, LM, Ferreira, AG, Berlinck, RGS, Eustáquio, AS. (2021). A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges**. Angewandte Chemie – International Edition, 60, (29), 15891-15898. doi:10.1002/anie.202017320.

Sullivan, P, Krunic, A, Davis, LJ, Kim, HS, Burdette, JE, Orjala, J. (2021). Phormidepistatin from the Cyanobacterium UIC 10484: Assessing the Phylogenetic Distribution of the Statine Pharmacophore. Journal of Natural Products. doi:10.1021/acs.jnatprod.1c00334.

Sullivan, P, Krunic, A, Burdette, JE, Orjala, J. (2020). Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484. Journal of Antibiotics, 73, (8), 526-533. doi:10.1038/s41429-020-0301-x.

Li, S, Newmister, SA, Lowell, AN, Zi, J, Chappell, CR, Yu, F, Hohlman, RM, Orjala, J, Williams, RM, Sherman, DH. (2020). Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases. Angewandte Chemie – International Edition, 59, (21), 8166-8172. doi:10.1002/anie.201913686.

May, DS, Crnkovic, CM, Krunic, A, Wilson, TA, Fuchs, JR, Orjala, JE. (2020). 15N Stable Isotope Labeling and Comparative Metabolomics Facilitates Genome Mining in Cultured Cyanobacteria. ACS Chemical Biology, 15, (3), 758-765. doi:10.1021/acschembio.9b00993.

Crnkovic, CM, Braesel, J, Krunic, A, Eustáquio, AS, Orjala, J. (2020). Scytodecamide from the Cultured Scytonema sp. UIC 10036 Expands the Chemical and Genetic Diversity of Cyanobactins. ChemBioChem, 21, (6), 845-852. doi:10.1002/cbic.201900511.

Guo, Y, Crnkovic, C, Won, KJ, Lee, JR, Orjala, J, Lee, H, Jeong, H. (2019). Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites. Drug Metabolism and Disposition, 47, (3), 194-202. doi:10.1124/dmd.118.084772.

Braesel, J, Crnkovic, CM, Kunstman, KJ, Green, SJ, Maienschein-Cline, M, Orjala, J, Murphy, BT, Eustáquio, AS. (2018). Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete. Journal of Natural Products, 81, (9), 2057-2068. doi:10.1021/acs.jnatprod.8b00394.

Crnkovic, CM, Krunic, A, May, DS, Wilson, TA, Kao, D, Burdette, JE, Fuchs, JR, Oberlies, NH, Orjala, J. (2018). Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520. Journal of Natural Products, 81, (9), 2083-2090. doi:10.1021/acs.jnatprod.8b00432.

Professional Leadership

American Society of Pharmacognosy, 11/15/2019 - Present

Education

Degrees:
PhD, Swiss Federal Institute of Technology in Zurich, Switzerland, 1993
Diploma of Pharmacy, Swiss Federal Institute of Technology in Zurich, Switzerland, 1988