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Photo of Jimmy Orjala

Jimmy Orjala

Professor, College of Pharmacy
Director of Graduate Studies for Pharmacognosy graduate program, College of Pharmacy - Pharmaceutical Sciences



900 South Ashland Avenue, Chicago, IL

Office Phone:

(312) 996-5583 (work)

Related Sites:

About Heading link

Research Interests:
1. Discovery, isolation, and structure elucidation of biological active metabolites from cultured cyanobacteria.
2. Application of sensitive analytical techniques to the structure elucidation and biological characterization of natural products.

Teaching and Supervision Heading link

PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
Doctoral Research in Pharmacog (PMPG 599), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Pharmacog Research Techniques (PSCI 520), 8/22/2022 – 12/2/2022
Doctoral Research in Pharmacog (PMPG 599), 8/22/2022 – 12/2/2022
Doctoral Research in Pharmacog (PMPG 599), 5/16/2022 – 7/21/2022
Doctoral Research in Pharmacog (PMPG 599), 1/10/2022 – 4/29/2022
PSCI Ph.D. Thesis Research (PSCI 599), 1/10/2022 – 4/29/2022
PDAT 2: GI/Endocrine (PHAR 502), 1/10/2022 – 4/29/2022

Selected Grants

Gut Bacterial O-demethylation, Purdue University., 9/1/2022 - 8/31/2023, Obligated Amount: $48048; Anticipated Amount: $48048

Pregnane X receptor (PXR)-activating gut bacterial metabolites, Purdue University., 4/8/2022 - 3/31/2024, Obligated Amount: $55214; Anticipated Amount: $55214

Discovery of Anticancer Agents of Diverse Natural Origin, Ohio State University., 5/15/2020 - 4/30/2023, Obligated Amount: $1004373; Anticipated Amount: $1004373

Role of a conserved gene cluster family in promoting motility behavior in proteobacteria and in mediating host interactions, National Science Foundation., 8/15/2019 - 7/31/2023, Obligated Amount: $546571; Anticipated Amount: $546571

Research Training in Natural Product Complementary and Integrative Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 1/1/2019 - 12/31/2023, Obligated Amount: $1317731; Anticipated Amount: $2100520

Selected Publications

Aldrich, LN, Burdette, JE, Carcache De Blanco, E, Coss, CC, Eustaquio, AS, Fuchs, JR, Kinghorn, AD, Macfarlane, A, Mize, BK, Oberlies, NH, Orjala, J, Pearce, CJ, Phelps, MA, Rakotondraibe, LH, Ren, Y, Soejarto, DD, Stockwell, BR, Yalowich, JC, Zhang, X. (2022). Discovery of Anticancer Agents of Diverse Natural Origin. Journal of Natural Products, 85, (3), 702-719. doi:10.1021/acs.jnatprod.2c00036.

Davis, LJ, Maldonado, AC, Khin, M, Krunic, A, Burdette, JE, Orjala, J. (2022). Aulosirazoles B and C from the Cyanobacterium Nostoc sp. UIC 10771: Analogues of an Isothiazolonaphthoquinone Scaffold that Activate Nuclear Transcription Factor FOXO3a in Ovarian Cancer Cells. Journal of Natural Products, 85, (3), 540-546. doi:10.1021/acs.jnatprod.1c01030.

Sullivan, P, Krunic, A, Davis, LJ, Kim, HS, Burdette, JE, Orjala, J. (2021). Phormidepistatin from the Cyanobacterium UIC 10484: Assessing the Phylogenetic Distribution of the Statine Pharmacophore. Journal of Natural Products, 84, (8), 2256-2264. doi:10.1021/acs.jnatprod.1c00334.

Ióca, LP, Dai, Y, Kunakom, S, Diaz-Espinosa, J, Krunic, A, Crnkovic, CM, Orjala, J, Sanchez, LM, Ferreira, AG, Berlinck, RGS, Eustáquio, AS. (2021). A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges**. Angewandte Chemie – International Edition, 60, (29), 15891-15898. doi:10.1002/anie.202017320.

Sullivan, P, Krunic, A, Burdette, JE, Orjala, J. (2020). Laxaphycins B5 and B6 from the cultured cyanobacterium UIC 10484. Journal of Antibiotics, 73, (8), 526-533. doi:10.1038/s41429-020-0301-x.

Li, S, Newmister, SA, Lowell, AN, Zi, J, Chappell, CR, Yu, F, Hohlman, RM, Orjala, J, Williams, RM, Sherman, DH. (2020). Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor-Induced Combinatorial Pairing of Stig Cyclases. Angewandte Chemie – International Edition, 59, (21), 8166-8172. doi:10.1002/anie.201913686.

May, DS, Crnkovic, CM, Krunic, A, Wilson, TA, Fuchs, JR, Orjala, JE. (2020). 15N Stable Isotope Labeling and Comparative Metabolomics Facilitates Genome Mining in Cultured Cyanobacteria. ACS Chemical Biology, 15, (3), 758-765. doi:10.1021/acschembio.9b00993.

Crnkovic, CM, Braesel, J, Krunic, A, Eustáquio, AS, Orjala, J. (2020). Scytodecamide from the Cultured Scytonema sp. UIC 10036 Expands the Chemical and Genetic Diversity of Cyanobactins. ChemBioChem, 21, (6), 845-852. doi:10.1002/cbic.201900511.

Guo, Y, Crnkovic, C, Won, KJ, Lee, JR, Orjala, J, Lee, H, Jeong, H. (2019). Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites. Drug Metabolism and Disposition, 47, (3), 194-202. doi:10.1124/dmd.118.084772.

Professional Leadership

American Society of Pharmacognosy, 11/15/2019 - Present


PhD, Swiss Federal Institute of Technology in Zurich, Switzerland, 1993
Diploma of Pharmacy, Swiss Federal Institute of Technology in Zurich, Switzerland, 1988