Paul R. Carlier
Director, UICentre, Pharmaceutical Sciences
Professor, Pharmaceutical Sciences
Professor, College of Liberal Arts & Sciences - Chemistry
Contact
Address:
833 S Wood St, Chicago, IL
Office Phone:
Email:
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About
Overview:
I am Director of UICentre, UIC’s campus-wide drug discovery enterprise. I am deeply honored to hold the Hans W. Vahlteich Chair in Medicinal Chemistry in the College of Pharmacy, where I am Professor in Pharmaceutical Sciences, I hold a secondary appointment as Professor of Chemistry in the College of Liberal Arts and Sciences
Research Interests:
Drug discovery for infectious disease, in particular malaria.
Teaching Statement:
Each Spring Term I team teach in PSCI 530 Medicinal Chemistry, focusing on drug metabolism and prodrugs.
Teaching and Supervision
Medicinal Chemistry (PSCI530), 2/27/2025 – 3/11/2025
PhD Thesis Research (CHEM 599), 1/13/2025 – 5/2/2025
PSCI Ph.D. Thesis Research (PSCI 599), 1/13/2025 – 5/2/2025
PSCI Ph.D. Thesis Research (PSCI 599), 8/26/2024 – 12/6/2024
MS Thesis Research (PSCI 598), 8/26/2024 – 12/6/2024
PhD Thesis Research (CHEM 599), 8/26/2024 – 12/6/2024
Medicinal Chemistry (PSCI 530), 2/22/2024 – 3/5/2024
PhD Thesis Research (CHEM 599), 1/8/2024 – 4/26/2024
PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
Selected Grants
Antibiotics for K. pneumoniae targeting the essential bacterial enzyme peptide-tRNA hydrolase, Bill and Melinda Gates Foundation., 1/1/2026 - 12/31/2028, No Obligated Amount Set; Anticipated Amount: $3040616
Development of antibacterial inhibitors of Klebsiella pneumoniae peptidyl-tRNA hydrolase, Chancellor's Translational Research Initiative., 6/1/2025 - 9/30/2025, No Obligated Amount Set; Anticipated Amount: $25000
Identification of small molecules to improve efficacy of cancer immunotherapy, Chancellor's Translational Research Initiative., 6/1/2024 - 9/30/2024, Obligated Amount: $25000; Anticipated Amount: $25000
A Chicago Biomedical Consortium Hub of Innovative Technologies for Entrepreneurship and Science (CBC - HITES), Northwestern University., 9/25/2023 - 8/31/2025, Obligated Amount: $45846; Anticipated Amount: $45846
Interrogating plasmodial endocytosis with mefloquine-based affinity probes, Virginia Tech., 2/1/2023 - 1/31/2024, Obligated Amount: $79950; Anticipated Amount: $79950
Optimization of antimalarials targeting multiple life stages of the parasite, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 8/4/2021 - 7/31/2026, Obligated Amount: $2488476.43; Anticipated Amount: $3237452.43
Clinical and Translational Science Award U54, National Institutes of Health (National Center for Advancing Translational Sciences)., 6/1/2020 - 5/31/2025, Obligated Amount: $18780341; Anticipated Amount: $18780341
Interrogating plasmodial endocytosis with mefloquine-based affinity probes, National Institute of Allergy and Infectious Diseases., 2/1/2020 - 1/31/2024, Obligated Amount: $428271; No Anticipated Amount Set
Prevention of Zika transmission with novel Aedes personal protective measures, National Institute of Allergy and Infectious Diseases., 9/10/2017 - 8/31/2021, Obligated Amount: $467868; No Anticipated Amount Set
Selected Publications
Sacramento, Carolina Q, Bott, Ryan, Huang, Qinfeng, Eaton, Brett, Postnikova, Elena, Sabir, Ahmad J, Argade, Malaika D, Ratia, Kiira, Anantpadma, Manu, Carlier, Paul R, Ly, Hinh, Liang, Yuying, Rong, Lijun. (2025). Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses. Antiviral Research, 236, 106117. doi:10.1016/j.antiviral.2025.106117.
Bremers, Emily K, Butler, Joshua H, Do Amaral, Leticia S, Merino, Emilio F, Almolhim, Hanan, Zhou, Bo, Baptista, Rodrigo P, Totrov, Maxim, Carlier, Paul R, Cassera, Maria Belen. (2025). Stereospecific Resistance to N2-Acyl Tetrahydro-β-carboline Antimalarials Is Mediated by a PfMDR1 Mutation That Confers Collateral Drug Sensitivity. ACS Infectious Diseases, 11, (2), 529-542. doi:10.1021/acsinfecdis.4c01001.
Mathew, Jopaul, Zhou, Bo, Haney, Reagan S, Kunz, Kevin A, Do Amaral, Leticia S, Chowdhury, Rudraneel Roy, Butler, Joshua H, Li, Haibo, Chakraborty, Amarraj J, Tabassum, Anika, Bremers, Emily K, Merino, Emilio F, Coyle, Rachael, Lee, Marcus CS, Baud, Delphine, Brand, Stephen, Totrov, Maxim, Cassera, Maria Belen, Carlier, Paul R. (2024). β‑Carboline-3-carboxamide Antimalarials: Structure–Activity Relationship, ADME-Tox Studies, and Resistance Profiling. ACS Infectious Diseases, 10, (11), 3951-3962. doi:10.1021/acsinfecdis.4c00653.
Rusu, Luiza, Bloem, Laura J, Chen, Hui, Lee, Hyun, Ratia, Kiira M, Jayathilaka, Lasanthi, Carlier, Paul R, Minshall, Richard D. (2024). Abstract 1063: G Protein 12 Alpha Subunit Covalent Binding To Alpha-snap And Its Potential Role In Von Willebrand Factor Secretion. Arteriosclerosis Thrombosis and Vascular Biology, 44, (Suppl_1), a1063-a1063. doi:10.1161/atvb.44.suppl_1.1063.
Do Amaral, Leticia, Bremers, Emily, Butler, Joshua, Merino, Emilio, Baptista, Rodrigo, Almolhim, Hanan, Totrov, Max, Carlier, Paul, Cassera, Maria. (2023). Abstract 2658: Characterizing the Mechanism of Resistance of PRC1590 Using Known Antimalarials. Journal of Biological Chemistry, 299, (3), s157. doi:10.1016/j.jbc.2023.103346.
Dye, Keane J, Vogelaar, Nancy J, O’Hara, Megan, Sobrado, Pablo, Santos, Webster, Carlier, Paul R, Yang, Zhaomin. (2022). Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds. Microbiology Spectrum, 10, (6), e03877-e03822. doi:10.1128/spectrum.03877-22.
Almolhim, Hanan, Ding, Sha, Butler, Joshua H, Bremers, Emily K, Butschek, Grant J, Slebodnick, Carla, Merino, Emilio F, Rizopoulos, Zaira, Totrov, Maxim, Cassera, Maria B, Carlier, Paul R. (2022). Enantiopure Benzofuran-2-carboxamides of 1‑Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro. ACS Medicinal Chemistry Letters, 13, (3), 371-376. doi:10.1021/acsmedchemlett.1c00697.
Mathew, Jopaul, Ding, Sha, Kunz, Kevin A, Stacy, Emily E, Butler, Joshua H, Haney, Reagan S, Merino, Emilio F, Butschek, Grant J, Rizopoulos, Zaira, Totrov, Maxim, Cassera, Maria B, Carlier, Paul R. (2022). Malaria Box-Inspired Discovery of N‑Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials. ACS Medicinal Chemistry Letters, 13, (3), 365-370. doi:10.1021/acsmedchemlett.1c00663.
Jack, Cameron J, Kleckner, Kaylin, Demares, Fabien, Rault, Leslie C, Anderson, Troy D, Carlier, Paul R, Bloomquist, Jeffrey R, Ellis, James D. (2022). Testing new compounds for efficacy against Varroa destructor and safety to honey bees (Apis mellifera). Pest Management Science, 78, (1), 159-165. doi:10.1002/ps.6617.
Notable Honors
2024, Hans W. Vahlteich Chair in Medicinal Chemistry, College of Pharmacy, University of Illinois Chicago
Education
Degrees:
PhD, Massachusetts Institute of Technology, United States, 1988
BA, Hamilton College, United States, 1983
Selected Presentations
Zhou, Bo, Carlier, Paul. (2025 May 15). Development of Imidazo[4,5-c]pyridine Antimalarials. ACS-MEDI-EFMC Frontiers in Medicinal Chemistry. Chicago, IL.
Zhou, Bo, Carlier, Paul. (2025 April 27). Development of Imidazo[4,5-c]pyridine Antimalarials. MIKIW 2025 Medicinal Chemistry Meeting-in-Miniature. Lawrence, KS.