Paul R. Carlier
Director, UICentre, Pharmaceutical Sciences
Professor, Pharmaceutical Sciences
Professor, College of Liberal Arts & Sciences - Chemistry
Contact
Address:
833 S Wood St, Chicago, IL
Office Phone:
Email:
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About
Overview:
I am Director of UICentre, UIC’s campus-wide drug discovery enterprise. I am deeply honored to hold the Hans W. Vahlteich Chair in Medicinal Chemistry in the College of Pharmacy, where I am Professor in Pharmaceutical Sciences, I hold a secondary appointment as Professor of Chemistry in the College of Liberal Arts and Sciences
Research Interests:
Drug discovery for infectious disease, in particular malaria.
Teaching Statement:
Each Spring Term I team teach in PSCI 530 Medicinal Chemistry, focusing on drug metabolism and prodrugs.
Teaching and Supervision
PSCI Ph.D. Thesis Research (PSCI 46138), 1/12/2026 – 5/1/2026
PhD Thesis Research (CHEM 18887), 1/12/2026 – 5/1/2026
Special Proj Pharm Sci (PSCI 46131), 1/12/2026 – 5/1/2026
PhD Thesis Research (CHEM 599), 8/25/2025 – 12/5/2025
PSCI Ph.D. Thesis Research (PSCI 599), 8/25/2025 – 12/5/2025
PSCI Ph.D. Thesis Research (PSCI 599), 6/16/2025 – 8/8/2025
Internship Pharmaceutical Sci (PSCI 591), 5/19/2025 – 8/8/2025
Medicinal Chemistry (PSCI530), 2/27/2025 – 3/11/2025
PhD Thesis Research (CHEM 599), 1/13/2025 – 5/2/2025
Selected Grants
Identifying inhibitors of the bacterial peptidyl-tRNA hydrolase, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 2/3/2026 - 1/31/2028, Obligated Amount: $440908; Anticipated Amount: $440908
Antibiotics for K. pneumoniae targeting the essential bacterial enzyme peptide-tRNA hydrolase, Bill and Melinda Gates Foundation., 1/1/2026 - 12/31/2028, No Obligated Amount Set; Anticipated Amount: $3040616
Designing Selective ?3 Adrenoreceptor Agonists to Treat Obesity, Biagon Inc., 11/1/2025 - 10/31/2026, Obligated Amount: $74921; Anticipated Amount: $74921
Development of antibacterial inhibitors of Klebsiella pneumoniae peptidyl-tRNA hydrolase, Chancellor's Translational Research Initiative., 6/1/2025 - 9/30/2025, No Obligated Amount Set; Anticipated Amount: $25000
Identification of small molecules to improve efficacy of cancer immunotherapy, Chancellor's Translational Research Initiative., 6/1/2024 - 9/30/2024, Obligated Amount: $25000; Anticipated Amount: $25000
A Chicago Biomedical Consortium Hub of Innovative Technologies for Entrepreneurship and Science (CBC - HITES), Northwestern University., 9/25/2023 - 8/31/2026, Obligated Amount: $69781; Anticipated Amount: $69781
Interrogating plasmodial endocytosis with mefloquine-based affinity probes, Virginia Tech., 2/1/2023 - 1/31/2024, Obligated Amount: $79950; Anticipated Amount: $79950
Optimization of antimalarials targeting multiple life stages of the parasite, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 8/4/2021 - 7/31/2026, Obligated Amount: $3176480.43; Anticipated Amount: $3237452.43
Clinical and Translational Science Award U54, National Institutes of Health (National Center for Advancing Translational Sciences)., 6/1/2020 - 10/25/2025, Obligated Amount: $18780341; Anticipated Amount: $18780341
Selected Publications
Gaisina, Irina N, Argade, Malaika D, Bott, Ryan, Bradley, Sean P, Tomorowicz, Łukasz, Alvarez, Mario, Achi, Jazmin M Galván, Cross, Robert W, Borisevich, Viktoriya, O’Toole, Rachel, Amaya, Moushimi, Zielinski, Christian A, Gaisin, Arsen M, Nikolic, Dejan, Carlier, Paul R, Anantpadma, Manu, Moore, Terry W, Broder, Christopher C, Geisbert, Thomas W, Peet, Norton P, Rong, Lijun. (2026). Discovery and Optimization of First-in-Class Furopyrimidine-Based Inhibitors of Henipaviruses. Journal of Medicinal Chemistry, 69, (2), 1264-1285. doi:10.1021/acs.jmedchem.5c02646.
Wang, Zilai, Zhang, Pin, Ratia, Kiira M, Daher, Ahmad, Zhao, Zongmin, Carlier, Paul R, Jiang, Yuwei, Rong, Lijun. (2025). Development of a comparative high-throughput screening platform for identifying glioblastoma subtype specific inhibitors. Cell Insight, 4, (6), 100284. doi:10.1016/j.cellin.2025.100284.
Haney, Reagan S, Butler, Joshua H, Wardlaw, Lyric A, Merino, Emilio F, Mendiola, Victoria, Cooper, Caitlin A, Mathew, Jopaul, Tumwebaze, Patrick K, Rosenthal, Philip J, Cooper, Roland A, Kyle, Dennis E, Rizopoulos, Zaira, Baud, Delphine, Brand, Stephen, Totrov, Maxim, Carlier, Paul R, Cassera, Maria Belen. (2025). Characterization of β‑Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant Plasmodium falciparum. ACS Infectious Diseases, 11, (11), 3310-3322. doi:10.1021/acsinfecdis.5c00714.
Swale, Daniel R, Carlier, Paul R, Totrov, Maxim, Bloomquist, Jeffrey R. (2025). Solvent-, enzyme-, and structural-dependence of phenyl-substituted methyl carbamate inhibition of acetylcholinesterase. Insect Biochemistry and Molecular Biology, 184, 104385. doi:10.1016/j.ibmb.2025.104385.
Ghavami, Maryam, Li, Haibo, Liu, Lixuan, Butler, Joshua H, Ding, Sha, Butschek, Grant J, Haney, Reagan S, Council-Troche, R McAlister, Grams, R Justin, Merino, Emilio F, Davis, Jennifer M, Totrov, Maxim, Cassera, Maria B, Carlier, Paul R. (2025). Benzo-ring modification on Malaria Box hit MMV008138: effects on antimalarial potency and microsomal stability. RSC Medicinal Chemistry, 16, (10), 5052-5058. doi:10.1039/d5md00439j.
Sacramento, Carolina Q, Bott, Ryan, Huang, Qinfeng, Eaton, Brett, Postnikova, Elena, Sabir, Ahmad J, Argade, Malaika D, Ratia, Kiira, Anantpadma, Manu, Carlier, Paul R, Ly, Hinh, Liang, Yuying, Rong, Lijun. (2025). Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses. Antiviral Research, 236, 106117. doi:10.1016/j.antiviral.2025.106117.
Bremers, Emily K, Butler, Joshua H, Do Amaral, Leticia S, Merino, Emilio F, Almolhim, Hanan, Zhou, Bo, Baptista, Rodrigo P, Totrov, Maxim, Carlier, Paul R, Cassera, Maria Belen. (2025). Stereospecific Resistance to N2-Acyl Tetrahydro-β-carboline Antimalarials Is Mediated by a PfMDR1 Mutation That Confers Collateral Drug Sensitivity. ACS Infectious Diseases, 11, (2), 529-542. doi:10.1021/acsinfecdis.4c01001.
Mathew, Jopaul, Zhou, Bo, Haney, Reagan S, Kunz, Kevin A, Do Amaral, Leticia S, Chowdhury, Rudraneel Roy, Butler, Joshua H, Li, Haibo, Chakraborty, Amarraj J, Tabassum, Anika, Bremers, Emily K, Merino, Emilio F, Coyle, Rachael, Lee, Marcus CS, Baud, Delphine, Brand, Stephen, Totrov, Maxim, Cassera, Maria Belen, Carlier, Paul R. (2024). β‑Carboline-3-carboxamide Antimalarials: Structure–Activity Relationship, ADME-Tox Studies, and Resistance Profiling. ACS Infectious Diseases, 10, (11), 3951-3962. doi:10.1021/acsinfecdis.4c00653.
Rusu, Luiza, Bloem, Laura J, Chen, Hui, Lee, Hyun, Ratia, Kiira M, Jayathilaka, Lasanthi, Carlier, Paul R, Minshall, Richard D. (2024). Abstract 1063: G Protein 12 Alpha Subunit Covalent Binding To Alpha-snap And Its Potential Role In Von Willebrand Factor Secretion. Arteriosclerosis Thrombosis and Vascular Biology, 44, (Suppl_1), a1063-a1063. doi:10.1161/atvb.44.suppl_1.1063.
Notable Honors
2024, Hans W. Vahlteich Chair in Medicinal Chemistry, College of Pharmacy, University of Illinois Chicago
Education
Degrees:
PhD, Massachusetts Institute of Technology, United States, 1988
BA, Hamilton College, United States, 1983
Selected Presentations
Zhou, Bo, Carlier, Paul. (2025 May 15). Development of Imidazo[4,5-c]pyridine Antimalarials. ACS-MEDI-EFMC Frontiers in Medicinal Chemistry. Chicago, IL.
Zhou, Bo, Carlier, Paul. (2025 April 27). Development of Imidazo[4,5-c]pyridine Antimalarials. MIKIW 2025 Medicinal Chemistry Meeting-in-Miniature. Lawrence, KS.