Paul R. Carlier
Director, UICentre, Pharmaceutical Sciences
Professor, Pharmaceutical Sciences
Professor, Chemistry
Contact
Address:
833 S Wood St, Chicago, IL
Office Phone:
Email:
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About Heading link
Overview:
I am Director of UICentre, UIC’s campus-wide drug discovery enterprise. I am jointly appointed as Professor in Pharmaceutical Sciences (primary) and Chemistry (secondary).
Research Interests:
Drug discovery for infectious disease, in particular malaria.
Teaching and Supervision Heading link
Medicinal Chemistry (PSCI530), 2/27/2023 – 3/7/2023
CHEM PhD Thesis Research (CHEM 599), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 1/9/2023 – 4/28/2023
PSCI Ph.D. Thesis Research (PSCI 599), 8/22/2022 – 12/2/2022
Selected Grants
Interrogating plasmodial endocytosis with mefloquine-based affinity probes, Virginia Tech., 2/1/2023 - 1/31/2024, Obligated Amount: $79950; Anticipated Amount: $79950
Optimization of antimalarials targeting multiple life stages of the parasite, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 8/4/2021 - 7/31/2026, Obligated Amount: $1717607.43; Anticipated Amount: $3039561.43
Interrogating plasmodial endocytosis with mefloquine-based affinity probes, National Institute of Allergy and Infectious Diseases., 2/1/2020 - 1/31/2024, Obligated Amount: $428271; No Anticipated Amount Set
Prevention of Zika transmission with novel Aedes personal protective measures, National Institute of Allergy and Infectious Diseases., 9/10/2017 - 8/31/2021, Obligated Amount: $467868; No Anticipated Amount Set
Structure- and ligand-based design of new IspD-targeting antimalarials, National Institute of Allergy and Infectious Diseases., 12/16/2016 - 11/30/2019, Obligated Amount: $431126; No Anticipated Amount Set
Development of vector-specific, resistance-breaking insecticides to reduce malari, National Institute of Allergy and Infectious Diseases., 4/1/2009 - 9/30/2015, Obligated Amount: $3413610; No Anticipated Amount Set
Configurationally stable carbanionic reagents for enantioselective synthesis, Directorate for Mathematical & Physical Sciences., 2/15/2008 - 1/31/2012, Obligated Amount: $365000; No Anticipated Amount Set
Lithiated Nitriles: Solution Structures and Reaction Stereochemistry, Directorate for Mathematical & Physical Sciences., 8/1/2002 - 7/31/2005, Obligated Amount: $240000; No Anticipated Amount Set
Selected Publications
Do Amaral, Leticia, Bremers, Emily, Butler, Joshua, Merino, Emilio, Baptista, Rodrigo, Almolhim, Hanan, Totrov, Max, Carlier, Paul, Cassera, Maria. (2023). Abstract 2658: Characterizing the Mechanism of Resistance of PRC1590 Using Known Antimalarials. Journal of Biological Chemistry, 299, (3), s157. doi:10.1016/j.jbc.2023.103346.
Dye, Keane J, Vogelaar, Nancy J, O’Hara, Megan, Sobrado, Pablo, Santos, Webster, Carlier, Paul R, Yang, Zhaomin. (2022). Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds. Microbiology Spectrum, 10, (6), e03877-e03822. doi:10.1128/spectrum.03877-22.
Almolhim, Hanan, Ding, Sha, Butler, Joshua H, Bremers, Emily K, Butschek, Grant J, Slebodnick, Carla, Merino, Emilio F, Rizopoulos, Zaira, Totrov, Maxim, Cassera, Maria B, Carlier, Paul R. (2022). Enantiopure Benzofuran-2-carboxamides of 1‑Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro. ACS Medicinal Chemistry Letters, 13, (3), 371-376. doi:10.1021/acsmedchemlett.1c00697.
Mathew, Jopaul, Ding, Sha, Kunz, Kevin A, Stacy, Emily E, Butler, Joshua H, Haney, Reagan S, Merino, Emilio F, Butschek, Grant J, Rizopoulos, Zaira, Totrov, Maxim, Cassera, Maria B, Carlier, Paul R. (2022). Malaria Box-Inspired Discovery of N‑Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials. ACS Medicinal Chemistry Letters, 13, (3), 365-370. doi:10.1021/acsmedchemlett.1c00663.
Jack, Cameron J, Kleckner, Kaylin, Demares, Fabien, Rault, Leslie C, Anderson, Troy D, Carlier, Paul R, Bloomquist, Jeffrey R, Ellis, James D. (2022). Testing new compounds for efficacy against Varroa destructor and safety to honey bees (Apis mellifera). Pest Management Science, 78, (1), 159-165. doi:10.1002/ps.6617.
Mak, Shinghung, Li, Wenming, Fu, Hongjun, Luo, Jialie, Cui, Wei, Hu, Shengquan, Pang, Yuanping, Carlier, Paul R, Tsim, Karl Wahkeung, Pi, Rongbiao, Han, Yifan. (2021). Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget. Journal of Neurochemistry, 158, (6), 1381-1393. doi:10.1111/jnc.15379.
Xuan, Zhenquan, Gu, Xinmei, Yan, Sicheng, Xie, Yanfei, Zhou, Yiying, Zhang, Hui, Jin, Haibo, Hu, Shengquan, Mak, Marvin SH, Zhou, Dongsheng, Tsim, Karl Wah Keung, Carlier, Paul R, Han, Yifan, Cui, Wei. (2021). Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer’s Disease. ACS Chemical Neuroscience, 12, (13), 2462-2477. doi:10.1021/acschemneuro.1c00182.
Ding, Sha, Ghavami, Maryam, Butler, Joshua H, Merino, Emilio F, Slebodnick, Carla, Cassera, Maria B, Carlier, Paul R. (2020). Probing the B- & C-rings of the antimalarial tetrahydro-β-carboline MMV008138 for steric and conformational constraints. Bioorganic & Medicinal Chemistry Letters, 30, (22), 127520. doi:10.1016/j.bmcl.2020.127520.
Ding, Sha, Fike, Katherine R, Klemba, Michael, Carlier, Paul R. (2020). In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs. Bioorganic & Medicinal Chemistry Letters, 30, (17), 127348. doi:10.1016/j.bmcl.2020.127348.
Education
Degrees:
PhD, Massachusetts Institute of Technology, United States, 1988
BA, Hamilton College, United States, 1983
Selected Presentations
Carlier, Paul. (2023 May 22). Prospecting for antimalarials using both target-based and phenotypic screening: discovery of an irresistible class?”. Seminar Series of the Department of Pharmacology and Regenerative Medicine.
Carlier, Paul. (2023 April 26). Mechanism-based and phenotypic screening for new antimalarials: discovery of an irresistible class?. Seminar Series of Biochemistry & Molecular Genetics. UIC, Chicago, IL.