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Photo of Seung Young Lee

Seung Young Lee


Assistant Professor, College of Pharmacy - Pharmaceutical Sciences

About Heading link

Research Interests:
The Lee laboratory aims to develop novel bioengineering tools and methods for pharmaceutical science research investigating cancer, vascular and inflammatory diseases. To better understand and improve pharmaco-kinetics and dynamics of therapeutic agents, we currently focus on developing: 1) Integrated molecular assay platforms; 2) High-throughput computational data analysis systems; and, 3) Combination drug delivery strategies.

Please visit the Lee Group’s Webpage: https://stevelee.lab.uic.edu/

Teaching and Supervision Heading link

Principles of Pharmaceutics and Drug Delivery (PSCI 510), 2/9/2022 – Present
PSCI Ph.D. Thesis Research (PSCI 599), 1/10/2022 – 4/29/2022
PhD Thesis Research (BPS 599), 1/10/2022 – 4/29/2022
Pharmaceutics & Drug Delivery (PSCI 510), 1/10/2022 – 4/29/2022
Undergrad Res Pharm Sci (PSCI 380), 1/10/2022 – 4/29/2022
Drug Discovery, Design, and Development (PSCI 501), 10/12/2021 – Present
Pharmaceutics I (PHAR 431), 9/20/2021 – Present
PSCI Ph.D. Thesis Research (PSCI 599), 8/23/2021 – 12/3/2021
PhD Thesis Research (BPS 599), 8/23/2021 – 12/3/2021

Selected Grants

Optogenetic Control of Tumor Initiation and Tumor Progression in vivo, National Institutes of Health (National Cancer Institute)., 6/8/2022 - 4/30/2025, Obligated Amount: $403638; Anticipated Amount: $1180936

Integrated three-dimensional (3D) microscopy for a spatial pharmacology atlas of macromolecular drugs in the tissue microenvironment, National Institutes of Health (National Institute of General Medical Sciences)., 9/24/2021 - 8/31/2026, Obligated Amount: $429705; Anticipated Amount: $2004049

Mechanism of CX3CR1+ macrophage-mediated resolution of eosinophilic allergic lung inflammation, National Institutes of Health (National Heart, Lung, and Blood Institute)., 5/10/2021 - 2/28/2026, Obligated Amount: $1171210; Anticipated Amount: $2809500

University of Illinois Cancer Center Pilot Program, UI Cancer Center., 9/1/2020 - 8/31/2021, Obligated Amount: $50000; No Anticipated Amount Set

Single-cell spatial proteomics for geographic profiling of the protein expression in ovarian tumors, University of Illinois Cancer Center., 9/1/2020 - 8/31/2021, Obligated Amount: $50000; Anticipated Amount: $50000

University of Illinois Cancer Center Pilot Program, UI Cancer Center., 9/1/2020 - 8/31/2021, Obligated Amount: $50000; No Anticipated Amount Set

Transparent Tumor Tomography (T3): Multi-Parameter 3D Imaging for Tumor Immunotherapy, National Institutes of Health (National Institute of Biomedical Imaging and Bioengineering)., 3/15/2019 - 4/30/2022, Obligated Amount: $746997; Anticipated Amount: $746997

Transparent Tumor Tomography (T3): Multi-parameter 3D imaging for tumor immunotherapy, National Institutes of Health., 4/2017 - 10/2018, No Obligated Amount Set; No Anticipated Amount Set

Selected Publications

Qiao, Guilin, Kone, Lyonell B, Phillips, Evan H, Lee, Steve Seung-Young, Brown, Grace E, Khetani, Salman R, Thakur, Archana, Lum, Lawrence G, Prabhakar, Bellur S, Maker, Ajay V. (2022). LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer. Oncogene, 41, (14), 2054-2068. doi:10.1038/s41388-022-02209-w.

Wu, Yi-Chien, Pagacz, Joanna, Emery, Samantha C, Kron, Stephen J, Lee, Steve Seung-Young. (2022). Chapter Nine Spatial mapping of the tumor immune microenvironment. Engineering Technologies and Clinical Translation. (pp. 293-329). doi:10.1016/b978-0-323-90949-5.00009-7.

Phillips, Evan H, Scholten, David, Flor, Amy C, Kron, Stephen J, Lee, Steve Seung-Young. (2021). Multiplexed Tissue Tomography. Multiplexed Imaging. (pp. 77-93). doi:10.1007/978-1-0716-1593-5_6.

Lee, Steve Seung-Young, Bindokas, Vytautas P, Kron, Stephen J. (2019). Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment. Molecular Cancer Therapeutics, 18, (1), molcanther.0554.2018. doi:10.1158/1535-7163.mct-18-0554.

Lee, Steve Seung-Young, Bindokas, Vytautas P, Lingen, Mark W, Kron, Stephen J. (2018). Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy. Laboratory Investigation, 99, (9), 1400-1413. doi:10.1038/s41374-018-0156-y.

Lee, Steve Seung-Young, Bindokas, Vytautas P, Kron, Stephen J. (2017). Multiplex three-dimensional optical mapping of tumor immune microenvironment. Scientific Reports, 7, (1), 17031. doi:10.1038/s41598-017-16987-x.

Lee, Steve Seung-Young, Li, Junjie, Tai, Jien Nee, Ratliff, Timothy L, Park, Kinam, Cheng, Ji-Xin. (2015). Avasimibe Encapsulated in Human Serum Albumin Blocks Cholesterol Esterification for Selective Cancer Treatment. ACS Nano, 9, (3), 2420-2432. doi:10.1021/nn504025a.

Lee, Seung-Young, Tyler, Jacqueline Y, Kim, Sungwon, Park, Kinam, Cheng, Ji-Xin. (2013). FRET Imaging Reveals Different Cellular Entry Routes of Self-Assembled and Disulfide Bonded Polymeric Micelles. Molecular Pharmaceutics, 10, (9), 3497-3506. doi:10.1021/mp4003333.

Lee, Seung‐Young, Cheng, Ji‐Xin. (2013). Clearance of Nanoparticles During Circulation. Pharmaceutical Sciences Encyclopedia. (pp. 1-32). doi:10.1002/9780470571224.pse496.

Education

Degrees:
PhD, Purdue University, United States, 2014
M.S.E, Gwangju Institute of Science and Technology, South Korea, 2007
B.S.E., Hongik University, South Korea, 2004

Postgraduate Training:
Research Experience, University of Chicago, United States, 2018
Ludwig Center for Metastasis Research, University of Chicago, United States, 2018
Research Experience, Purdue University, United States, 2014