Seung Young Lee
Assistant Professor, College of Pharmacy - Pharmaceutical Sciences
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About
Research Interests:
The Lee laboratory aims to develop novel bioengineering tools and methods for pharmaceutical science research investigating cancer, vascular and inflammatory diseases. To better understand and improve pharmaco-kinetics and dynamics of therapeutic agents, we currently focus on developing: 1) Integrated molecular assay platforms; 2) High-throughput computational data analysis systems; and, 3) Combination drug delivery strategies.
Please visit the Lee Group’s Webpage: https://stevelee.lab.uic.edu/
Teaching and Supervision
PSCI Ph.D. Thesis Research (PSCI 599), 1/13/2025 – 5/2/2025
Undergrad Res Pharm Sci (PSCI 380), 1/13/2025 – 5/2/2025
PSCI Ph.D. Thesis Research (PSCI 599), 8/26/2024 – 12/6/2024
Undergrad Res Pharm Sci (PSCI 380), 8/26/2024 – 12/6/2024
Undergrad Res Exp Pharm Sci (PSCI 300), 6/10/2024 – 8/2/2024
Internship Pharmaceutical Sci (PSCI 591), 5/13/2024 – 8/2/2024
PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
PhD Thesis Research (BPS 599), 1/8/2024 – 4/26/2024
Pharmaceutics & Drug Delivery (PSCI 510), 1/8/2024 – 4/26/2024
Selected Grants
Tumor subregion and immune cell type-selective proteomic profiling, National Institutes of Health (National Cancer Institute)., 12/1/2024 - 11/30/2026, Obligated Amount: $212367; Anticipated Amount: $387257
WASp signaling in T-cell lymphomas, National Institutes of Health (National Cancer Institute)., 7/15/2024 - 6/30/2029, Obligated Amount: $487014; Anticipated Amount: $2464068
Nanoparticle-coated macrophages for targeted disruption of YAP/TEAD interactions in breast cancer brain metastasis, National Institutes of Health (National Cancer Institute)., 6/1/2024 - 5/31/2026, Obligated Amount: $411143; Anticipated Amount: $411143
How Vitamin D Receptor Influences Intestinal Barriers, National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases)., 5/1/2024 - 2/29/2028, Obligated Amount: $501689; Anticipated Amount: $1973702
Combinatorial cytokine-coated macrophages for targeted immunomodulation in acute lung injury, National Institutes of Health (National Heart, Lung, and Blood Institute)., 8/1/2023 - 7/31/2025, Obligated Amount: $425757; Anticipated Amount: $425757
Three-dimensional organoid models to study breast cancer progression, NIH., 7/3/2023 - Present, Obligated Amount: $19789; No Anticipated Amount Set
Combinatorial cytokine-coated macrophages for targeted immunomodulation in acute lung injury, National Institutes of Health., 7/3/2023 - Present, Obligated Amount: $21602; No Anticipated Amount Set
Three-dimensional organoid models to study breast cancer progression, National Institutes of Health (National Cancer Institute)., 7/1/2023 - 6/30/2025, Obligated Amount: $826717; Anticipated Amount: $847965
Pilot study award, Uiversity of Illinois Cancer Center., 5/1/2023 - Present, Obligated Amount: $20000; No Anticipated Amount Set
Selected Publications
Zheng, Jingtian, Wu, Yi-Chien, Cai, Xiaoying, Phan, Philana, Gill, Meghna, Er, Ekrem Emrah, Zhao, Zongmin, Wang, Zaijie J, Lee, Steve Seung-Young. (2025). Correlative multiscale 3D imaging of mouse primary and metastatic tumors by sequential light sheet and confocal fluorescence microscopy. iScience, 28, (3), 111934. doi:10.1016/j.isci.2025.111934.
Zheng, Jingtian, Wu, Yi-Chien, Phillips, Evan H, Cai, Xiaoying, Wang, Xu, Seung-Young Lee, Steve. (2024). Increased Multiplexity in Optical Tissue Clearing-Based Three-Dimensional Immunofluorescence Microscopy of the Tumor Microenvironment by Light-Emitting Diode Photobleaching. Laboratory Investigation, 104, (6), 102072. doi:10.1016/j.labinv.2024.102072.
Phillips, Evan H, Bindokas, Vytautas P, Jung, Dahee, Teamer, Jay, Kitajewski, Jan K, Solaro, R John, Wolska, Beata M, Lee, Steve Seung‐Young. (2023). Three‐dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart. Microcirculation, 30, (7), e12826. doi:10.1111/micc.12826.
Wu, Yi-Chien, Moon, Hyung-Geun, Bindokas, Vytautas P, Phillips, Evan H, Park, Gye Young, Lee, Steve Seung-Young. (2023). Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung. American Journal of Respiratory Cell and Molecular Biology, 69, (1), 13-21. doi:10.1165/rcmb.2022-0353ma.
Moon, Hyung-Geun, Kim, Seung-Jae, Kim, Ki-Hyun, Kim, Young-Mee, Rehman, Jalees, Lee, Hyun, Wu, Yi-Chien, Lee, Steve Seung-Young, Christman, John W, Ackerman, Steven J, Kim, Minhyung, You, Sungyoung, Park, Gye Young. (2023). CX3CR1+ Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26.. American Journal of Respiratory and Critical Care Medicine, 207, (11), 1451-1463. doi:10.1164/rccm.202209-1670oc.
Zheng, Jingtian, Phillips, Evan, Wu, Yi-Chien, Lee, Steve Seung-Young, Bindokas, Vytautas. (2023). Abstract 4707: LED photobleaching-based multiplex 3D microscopy of the tumor microenvironment. Cancer Research, 83, (7_Supplement), 4707-4707. doi:10.1158/1538-7445.am2023-4707.
Qiao, Guilin, Kone, Lyonell B, Phillips, Evan H, Lee, Steve Seung-Young, Brown, Grace E, Khetani, Salman R, Thakur, Archana, Lum, Lawrence G, Prabhakar, Bellur S, Maker, Ajay V. (2022). LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer. Oncogene, 41, (14), 2054-2068. doi:10.1038/s41388-022-02209-w.
Wu, Yi-Chien, Pagacz, Joanna, Emery, Samantha C, Kron, Stephen J, Lee, Steve Seung-Young. (2022). Chapter Nine Spatial mapping of the tumor immune microenvironment. Engineering Technologies and Clinical Translation. (pp. 293-329). Elsevier. doi:10.1016/b978-0-323-90949-5.00009-7.
Phillips, Evan H, Scholten, David, Flor, Amy C, Kron, Stephen J, Lee, Steve Seung-Young. (2021). Multiplexed Tissue Tomography. Multiplexed Imaging. (pp. 77-93). Springer Nature. doi:10.1007/978-1-0716-1593-5_6.
Education
Degrees:
PhD, Purdue University, United States, 2014
M.S.E, Gwangju Institute of Science and Technology, South Korea, 2007
B.S.E., Hongik University, South Korea, 2004
Postgraduate Training:
Research Experience, University of Chicago, United States, 2018
Ludwig Center for Metastasis Research, University of Chicago, United States, 2018
Research Experience, Purdue University, United States, 2014
Selected Presentations
Lee, Steve. (2023 November 06). UIC College of Pharmacy Colloquium Seminar Series (BPS 425) at Chicago.