Seung Young Lee
Assistant Professor, College of Pharmacy - Pharmaceutical Sciences
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About Heading link
Research Interests:
The Lee laboratory aims to develop novel bioengineering tools and methods for pharmaceutical science research investigating cancer, vascular and inflammatory diseases. To better understand and improve pharmaco-kinetics and dynamics of therapeutic agents, we currently focus on developing: 1) Integrated molecular assay platforms; 2) High-throughput computational data analysis systems; and, 3) Combination drug delivery strategies.
Please visit the Lee Group’s Webpage: https://stevelee.lab.uic.edu/
Teaching and Supervision Heading link
PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
PhD Thesis Research (BPS 599), 1/8/2024 – 4/26/2024
Pharmaceutics & Drug Delivery (PSCI 510), 1/8/2024 – 4/26/2024
Undergrad Res Pharm Sci (PSCI 380), 1/8/2024 – 4/26/2024
PSCI Ph.D. Thesis Research (PSCI 599), 8/21/2023 – 12/1/2023
PhD Thesis Research (BPS 599), 8/21/2023 – 12/1/2023
Drug Discovery (PSCI 501), 8/21/2023 – 12/1/2023
Undergrad Res Exp Pharm Sci (PSCI 300), 6/12/2023 – 8/4/2023
Undergrad Res Pharm Sci (PSCI 380), 1/9/2023 – 4/28/2023
Selected Grants
Combinatorial cytokine-coated macrophages for targeted immunomodulation in acute lung injury, National Institutes of Health (National Heart, Lung, and Blood Institute)., 8/1/2023 - 7/31/2025, Obligated Amount: $192891; Anticipated Amount: $425757
Three-dimensional organoid models to study breast cancer progression, National Institutes of Health (National Cancer Institute)., 7/1/2023 - 6/30/2025, Obligated Amount: $423004; Anticipated Amount: $847965
UI Cancer Center Pilot Study Award, UI Cancer Center., 5/1/2023 - Present, Obligated Amount: $20000; No Anticipated Amount Set
NIGMS Administrative supplement, Office of the Director., 9/15/2022 - Present, Obligated Amount: $209288; No Anticipated Amount Set
PAX8 as a Drug Target for High-Grade Serous Cancer, US Department of Defense., 9/1/2022 - 8/31/2025, Obligated Amount: $713985; Anticipated Amount: $713985
PAX8 as a Drug Target for High-Grade Serous Cancer, U.S. Department of Defense., 9/1/2022 - Present, Obligated Amount: $83544; No Anticipated Amount Set
Optogenetic Control of Tumor Initiation and Tumor Progression in vivo, National Institutes of Health (National Cancer Institute)., 6/8/2022 - 4/30/2025, Obligated Amount: $1134299; Anticipated Amount: $1180936
NIGMS Diversity supplement, National Institutes of Health., 5/18/2022 - Present, Obligated Amount: $36119; No Anticipated Amount Set
Integrated three-dimensional (3D) microscopy for a spatial pharmacology atlas of macromolecular drugs in the tissue microenvironment, National Institutes of Health (National Institute of General Medical Sciences)., 9/24/2021 - 8/31/2026, Obligated Amount: $1534522; Anticipated Amount: $2321694
Selected Publications
Phillips, Evan H, Bindokas, Vytautas P, Jung, Dahee, Teamer, Jay, Kitajewski, Jan K, Solaro, R John, Wolska, Beata M, Lee, Steve Seung‐Young. (2023). Three‐dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart. Microcirculation, 30, (7), e12826. doi:10.1111/micc.12826.
Wu, Yi-Chien, Moon, Hyung-Geun, Bindokas, Vytautas P, Phillips, Evan H, Park, Gye Young, Lee, Steve Seung-Young. (2023). Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung. American Journal of Respiratory Cell and Molecular Biology, 69, (1), 13-21. doi:10.1165/rcmb.2022-0353ma.
Moon, Hyung-Geun, Kim, Seung-Jae, Kim, Ki-Hyun, Kim, Young-Mee, Rehman, Jalees, Lee, Hyun, Wu, Yi-Chien, Lee, Steve Seung-Young, Christman, John W, Ackerman, Steven J, Kim, Minhyung, You, Sungyoung, Park, Gye Young. (2023). CX3CR1+ Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26.. American Journal of Respiratory and Critical Care Medicine, 207, (11), 1451-1463. doi:10.1164/rccm.202209-1670oc.
Zheng, Jingtian, Phillips, Evan, Wu, Yi-Chien, Lee, Steve Seung-Young, Bindokas, Vytautas. (2023). Abstract 4707: LED photobleaching-based multiplex 3D microscopy of the tumor microenvironment. Cancer Research, 83, (7_Supplement), 4707-4707. doi:10.1158/1538-7445.am2023-4707.
Qiao, Guilin, Kone, Lyonell B, Phillips, Evan H, Lee, Steve Seung-Young, Brown, Grace E, Khetani, Salman R, Thakur, Archana, Lum, Lawrence G, Prabhakar, Bellur S, Maker, Ajay V. (2022). LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer. Oncogene, 41, (14), 2054-2068. doi:10.1038/s41388-022-02209-w.
Wu, Yi-Chien, Pagacz, Joanna, Emery, Samantha C, Kron, Stephen J, Lee, Steve Seung-Young. (2022). Chapter Nine Spatial mapping of the tumor immune microenvironment. Engineering Technologies and Clinical Translation. (pp. 293-329). Elsevier. doi:10.1016/b978-0-323-90949-5.00009-7.
Phillips, Evan H, Scholten, David, Flor, Amy C, Kron, Stephen J, Lee, Steve Seung-Young. (2021). Multiplexed Tissue Tomography. Multiplexed Imaging. (pp. 77-93). Springer Nature. doi:10.1007/978-1-0716-1593-5_6.
Lee, Steve Seung-Young, Bindokas, Vytautas P, Lingen, Mark W, Kron, Stephen J. (2019). Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy. Laboratory Investigation, 99, (9), 1400-1413. doi:10.1038/s41374-018-0156-y.
Lee, Steve Seung-Young, Bindokas, Vytautas P, Kron, Stephen J. (2019). Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment. Molecular Cancer Therapeutics, 18, (1), molcanther.0554.2018. doi:10.1158/1535-7163.mct-18-0554.
Education
Degrees:
PhD, Purdue University, United States, 2014
M.S.E, Gwangju Institute of Science and Technology, South Korea, 2007
B.S.E., Hongik University, South Korea, 2004
Postgraduate Training:
Research Experience, University of Chicago, United States, 2018
Ludwig Center for Metastasis Research, University of Chicago, United States, 2018
Research Experience, Purdue University, United States, 2014