Seung Young Lee
Assistant Professor, College of Pharmacy - Pharmaceutical Sciences
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About
Research Interests:
The Lee laboratory aims to develop novel bioengineering tools and methods for pharmaceutical science research investigating cancer, vascular and inflammatory diseases. To better understand and improve pharmaco-kinetics and dynamics of therapeutic agents, we currently focus on developing: 1) Integrated molecular assay platforms; 2) High-throughput computational data analysis systems; and, 3) Combination drug delivery strategies.
Please visit the Lee Group’s Webpage: https://stevelee.lab.uic.edu/
Teaching and Supervision
PSCI Ph.D. Thesis Research (PSCI 43730), 1/12/2026 – 5/1/2026
Pharmaceutics & Drug Delivery (PSCI 43725), 1/12/2026 – 5/1/2026
Undergrad Res Exp Pharm Sci (PSCI 45473), 1/12/2026 – 5/1/2026
PSCI Ph.D. Thesis Research (PSCI 599), 8/25/2025 – 12/5/2025
Drug Discovery (PSCI 501), 8/25/2025 – 12/5/2025
Undergrad Res Exp Pharm Sci (PSCI 300), 8/25/2025 – 12/5/2025
PSCI Ph.D. Thesis Research (PSCI 599), 6/16/2025 – 8/8/2025
PSCI Ph.D. Thesis Research (PSCI 599), 1/13/2025 – 5/2/2025
Undergrad Res Pharm Sci (PSCI 380), 1/13/2025 – 5/2/2025
Selected Grants
WASp signaling in T-cell lymphomas, National Institutes of Health (National Cancer Institute)., 7/1/2026 - 6/30/2029, Obligated Amount: $1504561; Anticipated Amount: $1504561
Microfluidic immunotherapy screening on a core needle biopsy, National Institutes of Health (National Cancer Institute)., 7/10/2025 - 6/30/2027, Obligated Amount: $386279; Anticipated Amount: $386279
Immunoregulatory Role of Conventional Dendritic Cell Type 2 in Allergic Lung Inflammation, National Institutes of Health (National Heart, Lung, and Blood Institute)., 5/15/2025 - 2/28/2029, Obligated Amount: $1491523; Anticipated Amount: $2997790
Tumor subregion and immune cell type-selective proteomic profiling, National Institutes of Health (National Cancer Institute)., 12/1/2024 - 11/30/2026, Obligated Amount: $387257; Anticipated Amount: $387257
WASp signaling in T-cell lymphomas, National Institutes of Health (National Cancer Institute)., 7/15/2024 - 6/30/2026, Obligated Amount: $959507; Anticipated Amount: $2464068
Nanoparticle-coated macrophages for targeted disruption of YAP/TEAD interactions in breast cancer brain metastasis, National Institutes of Health (National Cancer Institute)., 6/1/2024 - 5/31/2027, Obligated Amount: $411143; Anticipated Amount: $411143
How Vitamin D Receptor Influences Intestinal Barriers, National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases)., 5/1/2024 - 2/29/2028, Obligated Amount: $1488715; Anticipated Amount: $1973702
Combinatorial cytokine-coated macrophages for targeted immunomodulation in acute lung injury, National Institutes of Health (National Heart, Lung, and Blood Institute)., 8/1/2023 - 7/31/2026, Obligated Amount: $425757; Anticipated Amount: $425757
Three-dimensional organoid models to study breast cancer progression, NIH., 7/3/2023 - Present, Obligated Amount: $19789; No Anticipated Amount Set
Selected Publications
Rawool, Sarita, Ramseier, Neal Thomas, Maharjan, Samjhana, Lee, Steve S-L, Prasad, Krishna, Patel, Parakh B, Tamas, Jacob Michael, Bruno, Joshua, Glusac, Ksenija D, Snee, Preston T, Hu, Ying S, Ayitou, Anoklase Jean-Luc. (2026). Triplet Exciton Delocalization in Organic-Quantum Dot Hybrids as Potential Agents for Photodynamic Therapy and Theragnostic Applications. ACS Applied Nano Materials, 9, (15), 6631-6643. doi:10.1021/acsanm.6c00120.
Zhang, Endong, Algarni, Hanan, Zhang, Luyu, Chao, Chih-Jia, He, Shan, Upadhye, Aditi, Bao, Qing, Jung, Dahee, Srivastava, Shubhi, Udofa, Edidiong, Phan, Philana, Nikolic, Dejan S, Lee, Steve Seung-Young, Rehman, Jalees, Zhao, Zongmin. (2025). Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis. Science Advances, 11, (42), eady4135. doi:10.1126/sciadv.ady4135.
Kim, Young-Mee, Sanborn, Mark A, Vijeth, Shaluah, Gajwani, Priyanka, Wang, Xinge, Jung, Dahee, Valyi-Nagy, Tibor, Chakraborty, Sreeparna, Mancinelli, Georgina, Toth, Peter T, Phillips, Evan H, Grippo, Paul, Salahudeen, Ameen A, Park, Jooman, Yeon, Su Yeon, Ananthanarayanan, Vijayalakshmi, Jiang, Yuwei, Lee, Steve Seung-Young, Valyi-Nagy, Klara, Rehman, Jalees. (2025). Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia. Nature Cancer, 6, (8), 1350-1369. doi:10.1038/s43018-025-00975-6.
Jung, Dahee, Cai, Xiaoying, Oh, Wonkyung, Lim, Seung-Oe, Lee, Steve. (2025). Abstract 6085: Engineered anti-CD40 agonist antibody as a novel cancer neoantigen vaccine carrier. Cancer Research, 85, (8_Supplement_1), 6085-6085. doi:10.1158/1538-7445.am2025-6085.
Wu, Yi-Chien, Khalil, Elie Abi, Upadhye, Aditi, Rehman, Jalees, Kady, Nermin, Wilcox, Ryan, Lee, Steve. (2025). Abstract 2081: Tissue-niche-based and cell-type-selective proteomics. Cancer Research, 85, (8_Supplement_1), 2081-2081. doi:10.1158/1538-7445.am2025-2081.
Khalil, Elie Abi, Wu, Yi-Chien, Zheng, Jingtian, Plank, Joshua, Lippert, Alexander, Lee, Steve. (2025). Abstract 5253: Immune landscape analysis of solid tumors via spatially guided cell isolation for enhanced immunotherapeutic development. Cancer Research, 85, (8_Supplement_1), 5253-5253. doi:10.1158/1538-7445.am2025-5253.
Zheng, Jingtian, Wu, Yi-Chien, Cai, Xiaoying, Phan, Philana, Gill, Meghna, Er, Ekrem Emrah, Zhao, Zongmin, Wang, Zaijie J, Lee, Steve Seung-Young. (2025). Correlative multiscale 3D imaging of mouse primary and metastatic tumors by sequential light sheet and confocal fluorescence microscopy. iScience, 28, (3), 111934. doi:10.1016/j.isci.2025.111934.
Zheng, Jingtian, Wu, Yi-Chien, Phillips, Evan H, Cai, Xiaoying, Wang, Xu, Lee, Steve Seung-Young. (2024). Increased Multiplexity in Optical Tissue Clearing-Based Three-Dimensional Immunofluorescence Microscopy of the Tumor Microenvironment by Light-Emitting Diode Photobleaching. Laboratory Investigation, 104, (6), 102072. doi:10.1016/j.labinv.2024.102072.
Wu, Yi-Chien, Khalil, Elie Abi, Weng, Samuel, Lee, Steve. (2024). Abstract 3772: Tissue-niche-based and cell-type-selective in-depth proteomics. Cancer Research, 84, (6_Supplement), 3772-3772. doi:10.1158/1538-7445.am2024-3772.
Education
Degrees:
PhD, Purdue University, United States, 2014
M.S.E, Gwangju Institute of Science and Technology, South Korea, 2007
B.S.E., Hongik University, South Korea, 2004
Postgraduate Training:
Research Experience, University of Chicago, United States, 2018
Ludwig Center for Metastasis Research, University of Chicago, United States, 2018
Research Experience, Purdue University, United States, 2014