Terry Moore
Associate Professor, College of Pharmacy - Pharmaceutical Sciences
Director of Graduate Studies, College of Pharmacy - Pharmaceutical Sciences
Contact
Address:
833 S. Wood St. MC 781, Chicago, IL
Email:
Related Sites:
About Heading link
Overview:
Terry W. Moore is an Associate Professor and the Director of Graduate Studies in the Department of Pharmaceutical Sciences at the University of Illinois at Chicago. His research program focuses on designing, synthesizing, and characterizing new small molecule and peptide probes to modulate a number of different protein targets. Dr. Moore’s lab at UIC uses the tools of synthetic medicinal chemistry, peptide chemistry, drug discovery and chemical biology. Dr. Moore is extensively involved in the national and international medicinal chemistry community. Dr. Moore is a Topic editor at ACS Medicinal Chemistry Letters and has served as a guest editor at Molecular and Cellular Endocrinology. He has served on the Long-Range Planning committee of the American Chemical Society Division of Medicinal Chemistry and has been on the steering committees of national and international conferences in medicinal chemistry. Dr. Moore was named the UIC “Rising Star” Researcher of the Year for the Basic Life Sciences in 2018.
Research Interests:
Drug Discovery; medicinal chemistry; peptide chemistry
Teaching Statement:
Dr. Moore teaches in the PharmD and PhD program in Pharmaceutical Sciences curricula at UIC. He is the Director of Graduate Studies for Pharmaceutical Sciences and the Concentration Coordinator for Chemistry in Drug Discovery.
Dr. Moore teaches in several team-taught courses, including PHAR 422: Fundamentals of Drug Action I; PSCI 530: Principles of Medicinal Chemistry; PSCI 531: Spectroscopy in Pharmaceutical Sciences; PSCI 501: Drug Discovery, Design and Development.
He mentors junior faculty, research faculty, postdocs, graduate students, and undergraduate students.
Teaching and Supervision Heading link
PSCI Ph.D. Thesis Research (PSCI 599), 8/26/2024 – 12/6/2024
Drug Discovery (PSCI 501), 8/26/2024 – 12/6/2024
Fundamentals of Drug Action (PHAR 422), 8/26/2024 – 12/6/2024
Fundamentals of Drug Action (PHAR 422), 8/26/2024 – 12/6/2024
Undergrad Res Pharm Sci (PSCI 380), 8/26/2024 – 12/6/2024
Undergrad Res Exp Pharm Sci (PSCI 300), 8/26/2024 – 12/6/2024
PSCI Ph.D. Thesis Research (PSCI 599), 6/10/2024 – 8/2/2024
Medicinal Chemistry (PSCI 530), 1/9/2024 – 4/28/2024
PSCI Ph.D. Thesis Research (PSCI 599), 1/8/2024 – 4/26/2024
Selected Grants
Optimizing Ridaifen-B analogs as potential therapeutics for Ebola viruses, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 9/20/2022 - 7/31/2027, Obligated Amount: $2362748; Anticipated Amount: $3937392
Collaborative Research: OSIB: Chemical signaling in a host-microbe symbiosis, National Science Foundation., 8/15/2022 - 7/31/2025, Obligated Amount: $249751; Anticipated Amount: $249751
Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors, National Institutes of Health (National Institute of General Medical Sciences)., 8/1/2022 - 6/30/2027, Obligated Amount: $1521417; Anticipated Amount: $2097885
Novel therapeutic approaches for NPC Disease, National Institutes of Health (National Institute of Neurological Disorders and Stroke)., 7/1/2022 - 6/30/2027, Obligated Amount: $1759967; Anticipated Amount: $2928390
Midwest AViDD Center-Core C, University of Minnesota., 5/16/2022 - 4/30/2025, Obligated Amount: $1179021; Anticipated Amount: $1179021
Midwest AViDD Center-Project 1, University of Minnesota., 5/16/2022 - 4/30/2025, Obligated Amount: $911430; Anticipated Amount: $911430
Development of 4-(aroylamino)piperidine-based entry inhibitors as anti-influenza therapeutics, Chicago BioSolutions Inc., 5/5/2022 - 4/30/2025, Obligated Amount: $1351877; Anticipated Amount: $1351877
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, NIH/NIAID., 2/8/2022 - 1/31/2027, Obligated Amount: $454250; Anticipated Amount: $3299182
Selected Publications
Argade, Malaika D, Achi, Jazmin Galván, Bott, Ryan, Morsheimer, Kimberly M, Owen, Callum D, Zielinski, Christian A, Gaisin, Arsen M, Alvarez, Mario, Moore, Terry W, Bu, Fan, Li, Fang, Cameron, Michael, Anantpadma, Manu, Davey, Robert A, Peet, Norton P, Rong, Lijun, Gaisina, Irina N. (2024). Guardians at the Gate: Optimization of Small Molecule Entry Inhibitors of Ebola and Marburg Viruses. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.4c01646.
Maloney, Robert, Junod, Samuel L, Hagen, Kyla M, Lewis, Todd, Cheng, Changfeng, Shajan, Femil J, Zhao, Mi, Moore, Terry W, Truong, Thu H, Yang, Weidong, Wang, Rongsheng E. (2024). Flexible Fluorine-Thiol Displacement Stapled Peptides with Enhanced Membrane Penetration for the Estrogen Receptor/Coactivator Interaction. Journal of Biological Chemistry, 107991. doi:10.1016/j.jbc.2024.107991.
Durante, Destiny, Bott, Ryan, Cooper, Laura, Owen, Callum, Morsheimer, Kimberly M, Patten, JJ, Zielinski, Christian, Peet, Norton P, Davey, Robert A, Gaisina, Irina N, Rong, Lijun, Moore, Terry W. (2024). N‑Substituted Pyrrole-Based Heterocycles as Broad-Spectrum Filoviral Entry Inhibitors. Journal of Medicinal Chemistry, 67, (16), 13737-13764. doi:10.1021/acs.jmedchem.4c00527.
Naidu, Sharadha Dayalan, Dikovskaya, Dina, Cafferkey, Annamarie J, Novak, Miroslav, Suzuki, Takafumi, Knatko, Elena V, Moore, Terry W, Wells, Geoffrey, Dinkova-Kostova, Albena T. (2024). Electrophiles and Keap1-Nrf2 protein-protein interaction inhibitors for prevention and treatment of chronic disease. Free Radical Biology and Medicine, 218, 3. doi:10.1016/j.freeradbiomed.2024.04.016.
Moore, Terry W, Pomerantz, William CK. (2024). Celebrating the 60th Anniversary of the MIKIW Meeting-in-Miniature: Virtual Special Issue. ACS Medicinal Chemistry Letters, 15, (5), 565-566. doi:10.1021/acsmedchemlett.4c00139.
Moore, Terry W, Pomerantz, William CK. (2024). Celebrating the 60th Anniversary of the MIKIW Meeting-in-Miniature: Virtual Special Issue. Journal of Medicinal Chemistry, 67, (9), 6895-6896. doi:10.1021/acs.jmedchem.4c00716.
Gaisina, Irina, Li, Ping, Du, Ruikun, Cui, Qinghua, Dong, Meiyue, Zhang, Chengcheng, Manicassamy, Balaji, Caffrey, Michael, Moore, Terry, Cooper, Laura, Rong, Lijun. (2024). An orally active entry inhibitor of influenza A viruses protects mice and synergizes with oseltamivir and baloxavir marboxil. Science Advances, 10, (8), eadk9004. doi:10.1126/sciadv.adk9004.
Dean, Trevor T, Jelú-Reyes, Juliet, Allen, A’Lester C, Moore, Terry W. (2024). Peptide–Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics. Journal of Medicinal Chemistry, 67, (3), 1641-1661. doi:10.1021/acs.jmedchem.3c01835.
Skowron, Kornelia J, Baliga, Chetana, Johnson, Tatum, Kremiller, Kyle M, Castroverde, Alexandra, Dean, Trevor T, Allen, A’Lester C, Lopez-Hernandez, Ana M, Aleksandrova, Elena V, Klepacki, Dorota, Mankin, Alexander S, Polikanov, Yury S, Moore, Terry W. (2023). Structure–Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin. Journal of Medicinal Chemistry, 66, (17), 11831-11842. doi:10.1021/acs.jmedchem.3c00406.
Professional Leadership
Long-Range Planning Committee of ACS MEDI Division, American Chemical Society, 2018 - 2020
AACR Chemistry in Cancer Research, 2016 - 2019
MIKI meeting-in-miniature, 2014 - 2015
Notable Honors
2020, PhLAMEs Mentor of the Year,
2018, UIC “Rising Star” award,
2018, MEDI Young Investigator Symposium Awardee, ACS National Meeting,
2017, UIC College of Pharmacy Vahlteich Research Award,
2014, UIC College of Pharmacy P1 Teacher of the Semester,
2014, American Association of Colleges of Pharmacy New Investigator Award,
2011, The Anthony Shuker Scientific Poster Award,
2011, Emory Head and Neck Cancer SPORE Career Development Award,
2005, Pfizer Fellowship Supporting Diversity in Organic Chemistry,
Education
Degrees:
Ph.D., University of Illinois at Urbana-Champaign, United States, 2008
B.A. in Biochemistry, Abilene Christian University, United States, 2000
Postgraduate Training:
Postdoc, Emory Institute for Drug Development, United States, 2013
Postdoc, University of Illinois at Urbana Champaign, United States, 2009
Selected Presentations
Moore, Terry. (2024 February 06). Optimization of agents active against E. coli and Filoviruses..