Terry Moore
Associate Professor, College of Pharmacy - Pharmaceutical Sciences
Director of Graduate Studies, College of Pharmacy - Pharmaceutical Sciences
Contact
Address:
833 S. Wood St. MC 781, Chicago, IL
Email:
Related Sites:
About
Overview:
Terry W. Moore is an Associate Professor and the Director of Graduate Studies in the Department of Pharmaceutical Sciences at the University of Illinois at Chicago. His research program focuses on designing, synthesizing, and characterizing new small molecule and peptide probes to modulate a number of different protein targets. Dr. Moore’s lab at UIC uses the tools of synthetic medicinal chemistry, peptide chemistry, drug discovery and chemical biology. Dr. Moore is extensively involved in the national and international medicinal chemistry community. Dr. Moore is a Topic editor at ACS Medicinal Chemistry Letters and has served as a guest editor at Molecular and Cellular Endocrinology. He has served on the Long-Range Planning committee of the American Chemical Society Division of Medicinal Chemistry and has been on the steering committees of national and international conferences in medicinal chemistry. Dr. Moore was named the UIC “Rising Star” Researcher of the Year for the Basic Life Sciences in 2018.
Research Interests:
Drug Discovery; medicinal chemistry; peptide chemistry
Teaching Statement:
Dr. Moore teaches in the PharmD and PhD program in Pharmaceutical Sciences curricula at UIC. He is the Director of Graduate Studies for Pharmaceutical Sciences and the Concentration Coordinator for Chemistry in Drug Discovery.
Dr. Moore teaches in several team-taught courses, including PHAR 422: Fundamentals of Drug Action I; PSCI 530: Principles of Medicinal Chemistry; PSCI 531: Spectroscopy in Pharmaceutical Sciences; PSCI 501: Drug Discovery, Design and Development.
He mentors junior faculty, research faculty, postdocs, graduate students, and undergraduate students.
Teaching and Supervision
PSCI Ph.D. Thesis Research (PSCI 599), 8/25/2025 – 12/5/2025
Drug Discovery (PSCI 501), 8/25/2025 – 12/5/2025
Special Proj Pharm Sci (PSCI 390), 8/25/2025 – 12/5/2025
PSCI Ph.D. Thesis Research (PSCI 599), 6/16/2025 – 8/8/2025
Undergrad Res Exp Pharm Sci (PSCI 300), 6/16/2025 – 8/8/2025
PSCI Ph.D. Thesis Research (PSCI 599), 1/13/2025 – 5/2/2025
Special Proj Pharm Sci (PSCI 390), 1/13/2025 – 5/2/2025
Undergrad Res Pharm Sci (PSCI 380), 1/13/2025 – 5/2/2025
Undergrad Res Exp Pharm Sci (PSCI 300), 1/13/2025 – 5/2/2025
Selected Grants
Optimizing Ridaifen-B analogs as potential therapeutics for Ebola viruses., 8/1/2025 - 7/31/2027, Obligated Amount: $1574644; Anticipated Amount: $1574644
Minimal Modification, Maximum Insight: Next-Generation Peptide Imaging in vivo., 8/1/2025 - 7/31/2030, Obligated Amount: $560000; Anticipated Amount: $560000
Optimizing Ridaifen-B analogs as potential therapeutics for Ebola viruses., 9/20/2022 - 7/31/2027, Obligated Amount: $2362748; Anticipated Amount: $3937392
Collaborative Research: OSIB: Chemical signaling in a host-microbe symbiosis., 8/15/2022 - 7/31/2025, Obligated Amount: $249751; Anticipated Amount: $249751
Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors., 8/1/2022 - 6/30/2027, Obligated Amount: $1905708; Anticipated Amount: $2097885
Novel therapeutic approaches for NPC Disease., 7/1/2022 - 6/30/2027, Obligated Amount: $2335546; Anticipated Amount: $2928390
Midwest AViDD Center-Core C., 5/16/2022 - 4/30/2025, Obligated Amount: $1179021; Anticipated Amount: $1179021
Midwest AViDD Center-Project 1., 5/16/2022 - 4/30/2025, Obligated Amount: $1267541; Anticipated Amount: $1267541
Development of 4-(aroylamino)piperidine-based entry inhibitors as anti-influenza therapeutics., 5/5/2022 - 4/30/2026, Obligated Amount: $1351877; Anticipated Amount: $1351877
Selected Publications
Durante, Destiny, Murugesh, Venkatesh, Kalanquin, Tyler, Gaisina, Irina N, Rong, Lijun, Moore, Terry W. (2025). Small molecule drug discovery for Ebola virus disease. RSC Medicinal Chemistry, 16, (10), 4571-4598. doi:10.1039/d5md00533g.
Argade, Malaika D, Anirudhan, Varada, Bradley, Sean P, Tomorowicz, Łukasz, Bott, Ryan, Sownthirarajan, Boopathi, Zielinski, Christian A, Sloan, John P, Nikolic, Dejan S, Gaisin, Arsen M, Moore, Terry W, Manicassamy, Balaji, Peet, Norton P, Rong, Lijun, Gaisina, Irina N. (2025). Corrigendum to “Refinement of imidazo[2,1-a]pyrimidines in pursuit of potential drug candidates against group 2 influenza A viruses” [Europ. J. Med. Chem. 2925 (2025) 117679]. European Journal of Medicinal Chemistry, 294, 117766. doi:10.1016/j.ejmech.2025.117766.
Xu, Yan, Anirudhan, Varada, Gaisina, Irina N, Du, Haijuan, Alqarni, Saad, Moore, Terry W, Caffrey, Michael, Manicassamy, Balaji, Zhou, Tongqing, Rong, Lijun, Xu, Kai. (2025). Mechanistic insights into the small-molecule inhibition of influenza A virus entry. Proceedings of the National Academy of Sciences of the United States of America, 122, (33), e2503899122. doi:10.1073/pnas.2503899122.
Argade, Malaika D, Anirudhan, Varada, Bradley, Sean P, Tomorowicz, Łukasz, Bott, Ryan, Sownthirarajan, Boopathi, Zielinski, Christian A, Sloan, John P, Nikolic, Dejan S, Gaisin, Arsen M, Moore, Terry W, Manicassamy, Balaji, Peet, Norton P, Rong, Lijun, Gaisina, Irina N. (2025). Refinement of imidazo[2,1-a]pyrimidines in pursuit of potential drug candidates against group 2 influenza A viruses. European Journal of Medicinal Chemistry, 292, 117679. doi:10.1016/j.ejmech.2025.117679.
Novak, Miroslav, Naidu, Sharadha Dayalan, Dikovskaya, Dina, Moore, Terry W, Dinkova-Kostova, Albena T. (2025). Pharmacological inhibition of KEAP1 by cysteine-targeting electrophiles and non-electrophilic protein-protein interaction inhibitiors. Free Radical Biology and Medicine, 233, s94. doi:10.1016/j.freeradbiomed.2025.05.334.
Barakat, May, David, Brian P, Shi, Junhe, Xu, Angela, Moore, Terry W, Chen, Lin, DiPietro, Luisa A. (2025). Improved husbandry measures to enhance reproducibility of wound healing studies in the Leprdb/db mouse. Animal Models and Experimental Medicine, 8, (6), 1130-1137. doi:10.1002/ame2.70010.
Sofia, Michael J, Moore, Terry W, Pomper, Martin G. (2025). Annotated Bibliography of Prof. John A. Katzenellenbogen, PhD. Journal of Medicinal Chemistry, 68, (4), 3911-3942. doi:10.1021/acs.jmedchem.5c00224.
Sofia, Michael J, Moore, Terry W, Pomper, Martin G. (2025). Celebrating John A. Katzenellenbogen, PhD and His Contributions to Science and Medicine. Journal of Medicinal Chemistry, 68, (4), 3909-3910. doi:10.1021/acs.jmedchem.5c00225.
Argade, Malaika D, Achi, Jazmin Galván, Bott, Ryan, Morsheimer, Kimberly M, Owen, Callum D, Zielinski, Christian A, Gaisin, Arsen M, Alvarez, Mario, Moore, Terry W, Bu, Fan, Li, Fang, Cameron, Michael, Anantpadma, Manu, Davey, Robert A, Peet, Norton P, Rong, Lijun, Gaisina, Irina N. (2025). Guardians at the Gate: Optimization of Small Molecule Entry Inhibitors of Ebola and Marburg Viruses. Journal of Medicinal Chemistry, 68, (1), 135-155. doi:10.1021/acs.jmedchem.4c01646.
Professional Leadership
Long-Range Planning Committee of ACS MEDI Division, American Chemical Society, 2018 - 2020
AACR Chemistry in Cancer Research, 2016 - 2019
MIKI meeting-in-miniature, 2014 - 2015
Notable Honors
2020, PhLAMEs Mentor of the Year,
2018, UIC “Rising Star” award,
2018, MEDI Young Investigator Symposium Awardee, ACS National Meeting,
2017, UIC College of Pharmacy Vahlteich Research Award,
2014, UIC College of Pharmacy P1 Teacher of the Semester,
2014, American Association of Colleges of Pharmacy New Investigator Award,
2011, The Anthony Shuker Scientific Poster Award,
2011, Emory Head and Neck Cancer SPORE Career Development Award,
2005, Pfizer Fellowship Supporting Diversity in Organic Chemistry,
Education
Degrees:
Ph.D., University of Illinois at Urbana-Champaign, United States, 2008
B.A. in Biochemistry, Abilene Christian University, United States, 2000
Postgraduate Training:
Postdoc, Emory Institute for Drug Development, United States, 2013
Postdoc, University of Illinois at Urbana Champaign, United States, 2009
Selected Presentations
Moore, Terry. (2024 February 06). Optimization of agents active against E. coli and Filoviruses..