Photo of Terry Moore

Terry Moore


Associate Professor, College of Pharmacy - Pharmaceutical Sciences
Director of Graduate Studies, College of Pharmacy - Pharmaceutical Sciences

Contact

Address:

833 S. Wood St. MC 781, Chicago, IL

About

Overview:
Terry W. Moore is an associate professor of medicinal chemistry in the College of Pharmacy at the University of Illinois at Chicago. His research program focuses on designing, synthesizing, and characterizing new small molecule and peptide probes to modulate transcription factors, including nuclear receptors and NRF2. Dr. Moore’s lab at UIC uses the tools of synthetic medicinal chemistry, peptide chemistry, drug discovery and chemical biology. He is a member of the Early Career Board of ACS Medicinal Chemistry Letters, and he was a member of the organizing committee of the 2019 EFMC/MEDI Frontiers in Medicinal Chemistry Symposium in Krakow. Dr. Moore is a guest co-editor of a recent special issue of Molecular and Cellular Endocrinology on “Alternative Nuclear Receptor Ligands.” Because of these efforts, Dr. Moore was named the UIC “Rising Star” Researcher of the Year for the Basic Life Sciences in 2018.

Research Interests:
Drug Discovery; medicinal chemistry; peptide chemistry

Teaching and Supervision

Pharm Sciences Rotation (PSCI 592), 8/23/2021 – 12/3/2021
PSCI Ph.D. Thesis Research (PSCI 599), 8/23/2021 – 12/3/2021
Drug Discovery (PSCI 501), 8/23/2021 – 12/3/2021
Doctoral Restch in Med Chem (MDCH 599), 8/23/2021 – 12/3/2021
PSCI Ph.D. Thesis Research (PSCI 599), 6/14/2021 – 8/6/2021
Doctoral Restch in Med Chem (MDCH 599), 6/14/2021 – 8/6/2021
Medicinal Chemistry (PSCI 530), 1/11/2021 – 4/30/2021
Pharm Sciences Rotation (PSCI 592), 1/11/2021 – 4/30/2021
Doctoral Restch in Med Chem (MDCH 599), 1/11/2021 – 4/30/2021

Selected Grants

Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 7/16/2021 - 6/30/2022, Obligated Amount: $730027; Anticipated Amount: $730027

Selective Antagonists of Mutant Estrogen Receptors, American Cancer Society., 7/1/2021 - 6/30/2025, Obligated Amount: $792000; Anticipated Amount: $792000

Development of 4-(aroylamino) piperidine-based entry inhibitors as anti-influenza therapeutics, Chicago BioSolutions Inc., 4/2/2021 - 3/31/2022, Obligated Amount: $150310; Anticipated Amount: $150310

4- (Aminomethyl) Benzamides as Novel Anti-Ebola Agents, Chicago BioSolutions Inc., 8/16/2019 - 7/31/2022, Obligated Amount: $1039788; Anticipated Amount: $1039788

Development of group 2 influenza A virus entry inhibitors, Chicago BioSolutions Inc., 4/1/2019 - 3/31/2022, Obligated Amount: $336139; Anticipated Amount: $336139

Role of Nrf2 in Alveolar Epithelial Cell Regeneration During Lung Repair, National Institutes of Health (National Heart, Lung, and Blood Institute)., 8/10/2017 - 6/30/2022, Obligated Amount: $2052653; Anticipated Amount: $2052653

Binding of stapled peptides to estrogen receptor Molecular Dynamics Simulations of Chemical Probes that Inhibit Protein-Protein Interactions, NSF XSEDE Resource Allocation., 7/1/2017 - 6/30/2018, Obligated Amount: $22195; No Anticipated Amount Set

Binding of stapled peptides to estrogen receptor, NSF XSEDE Resource Allocation., 4/29/2017 - 4/28/2018, Obligated Amount: $1739; No Anticipated Amount Set

Non-Covalent Nrf2 Activators for the Treatment of Chronic Wounds, National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases)., 4/1/2017 - 2/28/2020, Obligated Amount: $1042272; Anticipated Amount: $1042272

Selected Publications

Horie, Y, Suzuki, T, Inoue, J, Iso, T, Wells, G, Moore, TW, Mizushima, T, Dinkova-Kostova, AT, Kasai, T, Kamei, T, Koshiba, S, Yamamoto, M. (2021). Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism. Communications Biology, 4, (1). doi:10.1038/s42003-021-02100-6.

Pomerantz, William CK. (2021). In This Issue, Volume 12, Issue 9. ACS Medicinal Chemistry Letters, 12, (9), 1357-1358. doi:10.1021/acsmedchemlett.1c00447.

Amaya, M, Cheng, H, Borisevich, V, Navaratnarajah, CK, Cattaneo, R, Cooper, L, Moore, TW, Gaisina, IN, Geisbert, TW, Rong, L, Broder, CC. (2021). A recombinant Cedar virus based high-throughput screening assay for henipavirus antiviral discovery. Antiviral Research, 193. doi:10.1016/j.antiviral.2021.105084.

Moore, Terry W. (2021). In This Issue, Volume 12, Issue 8. ACS Medicinal Chemistry Letters, 12, (8), 1181-1182. doi:10.1021/acsmedchemlett.1c00395.

Baliga, C, Brown, TJ, Florin, T, Colon, S, Shah, V, Skowron, KJ, Kefi, A, Szal, T, Klepacki, D, Moore, TW, Vázquez-Laslop, N, Mankin, AS. (2021). Charting the sequence-activity landscape of peptide inhibitors of translation termination. Proceedings of the National Academy of Sciences of the United States of America, 118, (10). doi:10.1073/pnas.2026465118.

Zink, KE, Ludvik, DA, Lazzara, PR, Moore, TW, Mandel, MJ, Sanchez, LM. (2021). A small molecule coordinates symbiotic behaviors in a host organ. mBio, 12, (2), 1-11. doi:10.1128/mBio.03637-20.

Moore, Terry W. (2020). In This Issue, Volume 11, Issue 12. ACS Medicinal Chemistry Letters, 11, (12), 2342-2343. doi:10.1021/acsmedchemlett.0c00616.

Mbachu, OC, Howell, C, Simmler, C, Malca Garcia, GR, Skowron, KJ, Dong, H, Ellis, SG, Hitzman, RT, Hajirahimkhan, A, Chen, SN, Nikolic, D, Moore, TW, Vollmer, G, Pauli, GF, Bolton, JL, Dietz, BM. (2020). SAR study on estrogen receptor α/β activity of (Iso)flavonoids: Importance of prenylation, c-ring (un)saturation, and hydroxyl substituents. Journal of Agricultural and Food Chemistry, 68, (39), 10651-10663. doi:10.1021/acs.jafc.0c03526.

Zink, Katherine E, Tarnowski, Denise A, Lazzara, Phillip R, Moore, Terry W, Mandel, Mark J, Sanchez, Laura M. (2020). Discovery of a microbially produced small molecule in a host-specific organ. , 2020.08.17.254854. doi:10.1101/2020.08.17.254854.

Professional Leadership

Session Organizer for American Chemical Society Meeting: Academic Drug Discovery, American Chemical Society, 4/5/2021 - 4/9/2021

Promotion and Tenure Review, Albany College of Pharmacy and Health Sciences, 10/1/2020 - 11/8/2020

Session Organizer for American Chemical Society Meeting: Gamechangers in Medicinal Chemistry, American Chemical Society, 8/16/2020 - 8/20/2020

Molecular and Cellular Endocrinology, 2018 - 2019

Long-Range Planning Committee of ACS MEDI Division, American Chemical Society, 2018 - 2020

AACR Chemistry in Cancer Research, 2016 - 2019

MIKI meeting-in-miniature, 2014 - 2015

Notable Honors

2020, PhLAMEs Mentor of the Year,

2018, UIC “Rising Star” award,

2018, MEDI Young Investigator Symposium Awardee, ACS National Meeting,

2017, UIC College of Pharmacy Vahlteich Research Award,

2014, UIC College of Pharmacy P1 Teacher of the Semester,

2014, American Association of Colleges of Pharmacy New Investigator Award,

2011, The Anthony Shuker Scientific Poster Award,

2011, Emory Head and Neck Cancer SPORE Career Development Award,

2005, Pfizer Fellowship Supporting Diversity in Organic Chemistry,

Education

Degrees:
Ph.D., University of Illinois at Urbana-Champaign, United States, 2008
B.A. in Biochemistry, Abilene Christian University, United States, 2000

Postgraduate Training:
Postdoc, Emory Institute for Drug Development, United States, 2013
Postdoc, University of Illinois at Urbana Champaign, United States, 2009