Yu Gao
Assistant Professor, Pharmaceutical Sciences
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About
Research Interests:
Proteomics, single-cell analysis, chemical biology
Teaching and Supervision
Doctoral Restch in Med Chem (MDCH 599), 8/23/2021 – 12/3/2021
PhD Thesis Research (BPS 599), 8/23/2021 – 12/3/2021
Medicinal Chemistry (PSCI 530), 1/11/2021 – 4/30/2021
Biomedicinal Chemistry (PHAR 423), 1/11/2021 – 4/30/2021
Biomedicinal Chemistry (PHAR 423), 1/11/2021 – 4/30/2021
PhD Thesis Research (BPS 599), 1/11/2021 – 4/30/2021
Seminar in Pharmacognosy (PMPG 595), 1/11/2021 – 4/30/2021
Seminar in Med Chem (MDCH 595), 1/11/2021 – 4/30/2021
Departmental Seminar (BPS 595), 1/11/2021 – 4/30/2021
Selected Grants
Palbociclib in combination with Tamoxifen as first line therapy for metastatic hormone receptor positive breast cancer, Big Ten Cancer Research Consortium., 6/1/2021 - 5/31/2021, Obligated Amount: $64063; Anticipated Amount: $64063
Defining the differential roles of HOIL1 and the Linear Ubiquitin Chain Assembly Complex in interferon induction by MDA5 and RIG-I during viral infection., National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 6/1/2021 - 5/31/2026, Obligated Amount: $355964; Anticipated Amount: $1945124
Identification of the target of meclonazepam in schistosome worms, Rush University Medical Center., 2/22/2021 - 1/31/2022, Obligated Amount: $79950; Anticipated Amount: $119925
Single-cell spatial proteomics for geographic profiling of the protein expression in ovarian tumors, University of Illinois Cancer Center., 9/1/2020 - 8/31/2021, Obligated Amount: $50000; Anticipated Amount: $50000
Highly sensitive proteomics method to probe cell heterogeneity at single cell resolution, National Institutes of Health (National Institute of General Medical Sciences)., 9/1/2019 - 6/30/2024, Obligated Amount: $1182267; Anticipated Amount: $1970445
Proteomics data analysis for the prediction of protein biomarkers, Shanghai Renascence Insurtech Limited Company., 1/1/2019 - 12/31/2019, Obligated Amount: $12792; Anticipated Amount: $12792
Selected Publications
Mangano, K, Florin, T, Shao, X, Klepacki, D, Chelysheva, I, Ignatova, Z, Gao, Y, Mankin, AS, Vázquez-Laslop, N. (2020). Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria. eLife, 9, 1-24. doi:10.7554/eLife.62655.
Shao, X, Taha, IN, Clauser, KR, Gao, Y, Naba, A. (2020). MatrisomeDB: The ECM-protein knowledge database. Nucleic Acids Research, 48, (D1), D1136-D1144. doi:10.1093/nar/gkz849.
Gao, Y, Dasgupta, C, Huang, L, Song, R, Zhang, Z, Zhang, L. (2019). Multi-Omics Integration Reveals Short and Long-Term Effects of Gestational Hypoxia on the Heart Development. Cells, 8, (12). doi:10.3390/cells8121608.
Gao, Y, Yates, JR. (2019). Protein analysis by shotgun proteomics. Mass Spectrometry-Based Chemical Proteomics. (pp. 1-38). doi:10.1002/9781118970195.ch1.
Jain, A, Jain, A, Parajuli, P, Mishra, V, Ghoshal, G, Singh, B, Shivhare, US, Katare, OP, Kesharwani, P. (2018). Recent advances in galactose-engineered nanocarriers for the site-specific delivery of siRNA and anticancer drugs. Drug Discovery Today, 23, (5), 960-973. doi:10.1016/j.drudis.2017.11.003.
Gao, Yu, Ma, Jiao, Saghatelian, Alan, Yates, John R. (2017). Targeted Searches for Novel Peptides in Big Mass Spectrometry Data Sets. , 239863. doi:10.1101/239863.
Aguilar, Aime Lopez, Gao, Yu, Hou, Xiaomeng, Lauvau, Gregoire, Yates, John R, Wu, Peng. (2017). Profiling of Protein O‑GlcNAcylation in Murine CD8+ Effector- and Memory-like T Cells. ACS Chemical Biology, 12, (12), 3031-3038. doi:10.1021/acschembio.7b00869.
Xu, T, Park, SK, Venable, JD, Wohlschlegel, JA, Diedrich, JK, Cociorva, D, Lu, B, Liao, L, Hewel, J, Han, X, Wong, CCL, Fonslow, B, Delahunty, C, Gao, Y, Shah, H, Yates, JR. (2015). ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity. Journal of Proteomics, 129, 16-24. doi:10.1016/j.jprot.2015.07.001.
Doran, Todd M, Gao, Yu, Simanski, Scott, McEnaney, Patrick, Kodadek, Thomas. (2015). High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies. Bioorganic & Medicinal Chemistry Letters, 25, (21), 4910-4917. doi:10.1016/j.bmcl.2015.05.046.
Education
Degrees:
PhD, Scripps Research Institute, United States