Yu Gao
Assistant Professor, Pharmaceutical Sciences
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About Heading link
Research Interests:
Proteomics, single-cell analysis, chemical biology
Teaching and Supervision Heading link
PhD Thesis Research (BPS 599), 1/10/2022 – 4/29/2022
Doctoral Restch in Med Chem (MDCH 599), 1/10/2022 – 4/29/2022
Medicinal Chemistry (PSCI 530), 1/10/2022 – 4/29/2022
Biomedicinal Chemistry (PHAR 423), 1/10/2022 – 4/29/2022
Biomedicinal Chemistry (PHAR 423), 1/10/2022 – 4/29/2022
Doctoral Restch in Med Chem (MDCH 599), 8/23/2021 – 12/3/2021
PhD Thesis Research (BPS 599), 8/23/2021 – 12/3/2021
Medicinal Chemistry (PSCI 530), 1/11/2021 – 4/30/2021
Biomedicinal Chemistry (PHAR 423), 1/11/2021 – 4/30/2021
Selected Grants
Elucidating the function of the non-classical HLA-DQ?2/HLA-DQ?2 in asthma, Chicago Biomedical Consortium., 10/1/2021 - 9/30/2023, Obligated Amount: $147274; Anticipated Amount: $147274
Palbociclib in combination with Tamoxifen as first line therapy for metastatic hormone receptor positive breast cancer, Big Ten Cancer Research Consortium., 6/1/2021 - 5/31/2021, Obligated Amount: $64063; Anticipated Amount: $64063
Defining the differential roles of HOIL1 and the Linear Ubiquitin Chain Assembly Complex in interferon induction by MDA5 and RIG-I during viral infection., National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 6/1/2021 - 5/31/2026, Obligated Amount: $778246; Anticipated Amount: $1945124
Identification of the target of meclonazepam in schistosome worms, Rush University Medical Center., 2/22/2021 - 1/31/2022, Obligated Amount: $79950; Anticipated Amount: $119925
Single-cell spatial proteomics for geographic profiling of the protein expression in ovarian tumors, University of Illinois Cancer Center., 9/1/2020 - 8/31/2021, Obligated Amount: $50000; Anticipated Amount: $50000
Highly sensitive proteomics method to probe cell heterogeneity at single cell resolution, National Institutes of Health (National Institute of General Medical Sciences)., 9/1/2019 - 6/30/2024, Obligated Amount: $1182267; Anticipated Amount: $1970445
Proteomics data analysis for the prediction of protein biomarkers, Shanghai Renascence Insurtech Limited Company., 1/1/2019 - 12/31/2019, Obligated Amount: $12792; Anticipated Amount: $12792
Selected Publications
Guo, Jian, Shen, Sam, Liu, Min, Wang, Chenjingyi, Low, Brian, Chen, Ying, Hu, Yaxi, Xing, Shipei, Yu, Huaxu, Gao, Yu, Fang, Mingliang, Huan, Tao. (2022). JPA: Joint Metabolic Feature Extraction Increases the Depth of Chemical Coverage for LC-MS-Based Metabolomics and Exposomics. Metabolites, 12, (3), 212. doi:10.3390/metabo12030212.
Mangano, Kyle, Florin, Tanja, Shao, Xinhao, Klepacki, Dorota, Chelysheva, Irina, Ignatova, Zoya, Gao, Yu, Mankin, Alexander S, Vázquez-Laslop, Nora. (2020). Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria. eLife, 9, e62655. doi:10.7554/elife.62655.
Gao, Yu, Dasgupta, Chiranjib, Huang, Lei, Song, Rui, Zhang, Ziwei, Zhang, Lubo. (2019). Multi-Omics Integration Reveals Short and Long-Term Effects of Gestational Hypoxia on the Heart Development. Cells, 8, (12), 1608. doi:10.3390/cells8121608.
Shao, Xinhao, Taha, Isra N, Clauser, Karl R, Gao, Yu, Naba, Alexandra. (2019). MatrisomeDB: the ECM-protein knowledge database. Nucleic Acids Research, 48, (D1), d1136-d1144. doi:10.1093/nar/gkz849.
Gao, Yu, Yates, John R. (2019). Protein Analysis by Shotgun Proteomics. Mass Spectrometry‐Based Chemical Proteomics. (pp. 1-38). doi:10.1002/9781118970195.ch1.
Gao, Yu, Ma, Jiao, Saghatelian, Alan, Yates, John R. (2017). Targeted Searches for Novel Peptides in Big Mass Spectrometry Data Sets. , 239863. doi:10.1101/239863.
Jain, Ashay, Jain, Atul, Parajuli, Prahlad, Mishra, Vijay, Ghoshal, Gargi, Singh, Bhupinder, Shivhare, Uma Shankar, Katare, Om Prakash, Kesharwani, Prashant. (2017). Recent advances in galactose-engineered nanocarriers for the site-specific delivery of siRNA and anticancer drugs. Drug Discovery Today, 23, (5), 960-973. doi:10.1016/j.drudis.2017.11.003.
Aguilar, Aime Lopez, Gao, Yu, Hou, Xiaomeng, Lauvau, Gregoire, Yates, John R, Wu, Peng. (2017). Profiling of Protein O‑GlcNAcylation in Murine CD8+ Effector- and Memory-like T Cells. ACS Chemical Biology, 12, (12), 3031-3038. doi:10.1021/acschembio.7b00869.
Xu, T, Park, SK, Venable, JD, Wohlschlegel, JA, Diedrich, JK, Cociorva, D, Lu, B, Liao, L, Hewel, J, Han, X, Wong, CCL, Fonslow, B, Delahunty, C, Gao, Y, Shah, H, Yates, JR. (2015). ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity. Journal of Proteomics, 129, 16-24. doi:10.1016/j.jprot.2015.07.001.
Education
Degrees:
PhD, Scripps Research Institute, United States