Yu Gao
Associate Professor, Pharmaceutical Sciences
Associate Member, University of Illinois Cancer Center
Affilated Member, Bioengineering
Contact
- Office Phone:
- (312) 996-8087 (work)
Email:
Related Sites:
About
Overview:
Gao lab website: https://lab.gy
Research Interests:
Proteomics, single-cell analysis, chemical biology
Teaching and Supervision
Bioinformatics for Pharm Sci (PSCI 47239), 3/9/2026 – 5/1/2026
Ph.D. Thesis Research (BME 47287), 1/12/2026 – 5/1/2026
PSCI Ph.D. Thesis Research (PSCI 45164), 1/12/2026 – 5/1/2026
MS Thesis Research (PSCI 49393), 1/12/2026 – 5/1/2026
Medicinal Chemistry (PSCI 44040), 1/12/2026 – 5/1/2026
Fundamentals of Drug Action II (PHAR 38921), 1/12/2026 – 5/1/2026
Fundamentals of Drug Action II (PHAR 38919), 1/12/2026 – 5/1/2026
Ph.D. Thesis Research (BME 599), 8/25/2025 – 12/5/2025
PSCI Ph.D. Thesis Research (PSCI 599), 8/25/2025 – 12/5/2025
Selected Grants
Highly sensitive proteomics method to probe cell heterogeneity at single cell resolution, National Institutes of Health (National Institute of General Medical Sciences)., 6/1/2026 - 4/30/2031, Obligated Amount: $429708; Anticipated Amount: $2148540
Deciphering the Function of the CCL22-CCR4 Axis in Adipose Beiging and Obesity, National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases)., 8/24/2025 - 5/31/2031, Obligated Amount: $777090; Anticipated Amount: $3885450
Mechanisms guiding the fibrillar assembly of SNED1 in the extracellular matrix, National Institutes of Health (National Institute of General Medical Sciences)., 8/4/2023 - 7/31/2027, Obligated Amount: $1237629; Anticipated Amount: $1237629
Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrix, National Institutes of Health (National Cancer Institute)., 9/15/2022 - 8/31/2026, Obligated Amount: $553146; Anticipated Amount: $564494
Thinking outside the cell: Leveraging HuBMAP data to build the human ECM atlas, National Institutes of Health (National Human Genome Research Institute)., 7/1/2022 - 4/30/2026, Obligated Amount: $2010000; Anticipated Amount: $2010000
Elucidating the function of the non-classical HLA-DQ?2/HLA-DQ?2 in asthma, Chicago Biomedical Consortium., 10/1/2021 - 9/30/2024, Obligated Amount: $147274; Anticipated Amount: $147274
Defining the differential roles of HOIL1 and the Linear Ubiquitin Chain Assembly Complex in interferon induction by MDA5 and RIG-I during viral infection., National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 6/1/2021 - 11/30/2026, Obligated Amount: $1945124; Anticipated Amount: $1945124
Palbociclib in combination with Tamoxifen as first line therapy for metastatic hormone receptor positive breast cancer, Big Ten Cancer Research Consortium., 6/1/2021 - 5/31/2021, Obligated Amount: $64063; Anticipated Amount: $64063
Identification of the target of meclonazepam in schistosome worms, Rush University Medical Center., 2/22/2021 - 1/31/2022, Obligated Amount: $79950; Anticipated Amount: $119925
Selected Publications
Khin, Manead, Saldana, Alejandra Cavazos, Rangel-Grimaldo, Manuel, Raja, Huzefa A, Abegg, Daniel, Ekiert, Julia, Liu, Chang, Misra, Sweta, Ratia, Kiira, Adibekian, Alexander, Gao, Yu, Kulp, Samuel K, Coss, Christopher C, Oberlies, Nicholas H, Burdette, Joanna E. (2026). Natural Product Target Identification of Wheldone, a Fungal Metabolite, as a KIF11 Inhibitor in Ovarian Cancer Using the DiffPOP (Differential Protein Precipitation) Method. Molecular & Cellular Proteomics, 25, (5), 101558. doi:10.1016/j.mcpro.2026.101558.
Mingolelli, Gabrielle, Raherisoanjato, Jessia, Trinh, Duong, Gao, Yu, Henke, Matthew. (2025). A core human gut microbe, Mediterraneibacter gnavus, produces a broad-spectrum bacteriocin mediterrocin. mBio, 16, (8), e01523-e01525. doi:10.1128/mbio.01523-25.
Jiang, Xinghang, Ly, Olivia T, Chen, Hanna, Zhang, Ziwei, Ibarra, Beatriz A, Pavel, Mahmud A, Brown, Grace E, Sridhar, Arvind, Tofovic, David, Swick, Abigail, Marszalek, Richard, Vanoye, Carlos G, Navales, Fritz, George, Alfred L, Khetani, Salman R, Rehman, Jalees, Gao, Yu, Darbar, Dawood, Saxena, Ankur. (2024). Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility. iScience, 27, (7), 110395. doi:10.1016/j.isci.2024.110395.
Chen, Liang, Zhang, Ziwei, Matsumoto, Cory, Gao, Yu. (2024). High-Throughput Proteomics Enabled by a Fully Automated Dual-Trap and Dual-Column LC-MS. Analytical Chemistry, 96, (24), 9761-9766. doi:10.1021/acs.analchem.3c03182.
Jain, Sanjay, Pei, Liming, Spraggins, Jeffrey M, Angelo, Michael, Carson, James P, Gehlenborg, Nils, Ginty, Fiona, Gonçalves, Joana P, Hagood, James S, Hickey, John W, Kelleher, Neil L, Laurent, Louise C, Lin, Shin, Lin, Yiing, Liu, Huiping, Naba, Alexandra, Nakayasu, Ernesto S, Qian, Wei-Jun, Radtke, Andrea, Robson, Paul, Stockwell, Brent R, Van de Plas, Raf, Vlachos, Ioannis S, Zhou, Mowei, Börner, Katy, Snyder, Michael P. (2024). Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP). Nature Cell Biology, 26, (5), 839-839. doi:10.1038/s41556-024-01384-0.
Maldonado, Amanda C, Haughan, Monica A, Khin, Manead, Ekiert, Julia, Zhang, Ziwei, Lantvit, Daniel, Al Subeh, Zeinab Y, Pierre, Herma C, Salkovski, Maryna, Hirschhorn, Tal, Gao, Yu, Pearce, Cedric J, Stockwell, Brent R, Aldrich, Leslie N, Oberlies, Nicholas H, Burdette, Joanna E. (2023). Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models. Journal of Natural Products, 86, (9), 2102-2110. doi:10.1021/acs.jnatprod.3c00186.
Jain, Sanjay, Pei, Liming, Spraggins, Jeffrey M, Angelo, Michael, Carson, James P, Gehlenborg, Nils, Ginty, Fiona, Gonçalves, Joana P, Hagood, James S, Hickey, John W, Kelleher, Neil L, Laurent, Louise C, Lin, Shin, Lin, Yiing, Liu, Huiping, Naba, Alexandra, Nakayasu, Ernesto S, Qian, Wei-Jun, Radtke, Andrea, Robson, Paul, Stockwell, Brent R, Van de Plas, Raf, Vlachos, Ioannis S, Zhou, Mowei, Börner, Katy, Snyder, Michael P. (2023). Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP). Nature Cell Biology, 25, (8), 1089-1100. doi:10.1038/s41556-023-01194-w.
Zhang, Ziwei, Ma, Xiuyuan, Ekiert, Julia, Mohapatra, Gayatry, Coleman, Louis, Truica, Cristina I, Blaes, Anne, Rana, Jatin, Pavankumar, Tandra, Green, Lauren, Yu, Menggang, Toppmeyer, Deborah, O’Regan, Ruth, Wisinski, Kari B, Danciu, Oana C, Hoskins, Kent, Gao, Yu. (2023). Abstract P5-02-47: Quantitative proteomic analysis of plasma exosomes from patients with advanced hormone receptor-positive/HER2-negative breast cancer receiving palbociclib and tamoxifen. Cancer Research, 83, (5_Supplement), p5-02-47-p5-02-47. doi:10.1158/1538-7445.sabcs22-p5-02-47.
Shao, Xinhao, Grams, Christopher, Gao, Yu. (2023). Sequence Coverage Visualizer: A Web Application for Protein Sequence Coverage 3D Visualization. Journal of Proteome Research, 22, (2), 343-349. doi:10.1021/acs.jproteome.2c00358.
Education
Degrees:
PhD, Scripps Research Institute, United States