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Photo of Zaijie Wang

Zaijie Wang


Distinguished Professor, University of Illinois Chicago
Professor of Pharmacology and Pharmaceutics, College of Pharmacy - Pharmaceutical Sciences

Related Sites:

About Heading link

Overview:
https://zjwang.lab.uic.edu/

Research Interests:
Pain

Addiction

(
Neurobiology
Epigenetics
Pharmacology
Natural product pharmacology; CNS drug discovery
Targeted delivery
)

Teaching and Supervision Heading link

PhD Thesis Research (BPS 599), 8/21/2023 – 12/1/2023
Undergrad Res Exp Pharm Sci (PSCI 300), 8/21/2023 – 12/1/2023
PhD Thesis Research (BPS 599), 1/9/2023 – 4/28/2023
PhD Thesis Research (BPS 599), 8/22/2022 – 12/2/2022
PhD Thesis Research (BPS 599), 1/10/2022 – 4/29/2022
PSCI Ph.D. Thesis Research (PSCI 599), 1/10/2022 – 4/29/2022
PRINCIPLES OF DRUG ACTION AND THERAPEUTICS (PDAT 507), 8/16/2021 – 2030
PHARMACOKINETICS (PHAR 435), 1/11/2021 – 12/31/2030
Pharmacodynamics of Drug Abuse (BPS542), 1/11/2021 – 4/30/2030

Selected Grants

Erythrocyte Autophagy Proteins as Potential Non-opioid Novel Targets for Pain in Sickle Cell Disease, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/22/2022 - 8/31/2024, Obligated Amount: $455195; Anticipated Amount: $455195

“Identification of Natural Products with Translational Potential for Management of Chronic Pain”, NIH/NCCIH (ODS)., 9/20/2019 - 6/30/2020, Obligated Amount: $191.393; No Anticipated Amount Set

Regulation of Trigeminal Nociception by TRESK Channels, National Institute of Neurological Disorders and Stroke., 4/1/2018 - 3/30/2023, Obligated Amount: $251595; No Anticipated Amount Set

Molecular Mechanism and Targeting of Chronic Pain in Sickle Cell Disease, National Institutes of Health (National Heart, Lung, and Blood Institute)., 1/16/2018 - 12/31/2024, Obligated Amount: $3240850; Anticipated Amount: $4629786

Molecular Mechanism and Targeting of Chronic Pain in Sickle Cell Disease, National Institutes of Health (National Heart, Lung, and Blood Institute)., 1/16/2018 - 12/31/2024, Obligated Amount: $3240850; Anticipated Amount: $4629786

microRNA as a Target for Fetal Hemoglobin Inducing Agents in Sickle Cell Disease, National Institutes of Health (National Heart, Lung, and Blood Institute)., 5/1/2017 - 10/30/2019, Obligated Amount: $273964; Anticipated Amount: $273964

Cortical opioid dysfunction in chronic pain, National Institute on Drug Abuse., 4/15/2016 - 1/31/2022, Obligated Amount: $2733196; No Anticipated Amount Set

Cortical Opioid Dysfunction in Chronic Pain, University of Arizona., 4/15/2016 - 1/31/2022, Obligated Amount: $1039350; No Anticipated Amount Set

Botanical Dietary Supplements for Women's Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2022, Obligated Amount: $9708015; Anticipated Amount: $12588944

Selected Publications

Kashyap, Yavnika, Wang, Zaijie Jim. (2024). Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease. Pain, 165, (2), 423-439. doi:10.1097/j.pain.0000000000003034.

He, Ying, Guo, Xiao, Molokie, Robert, Wang, Zaijie Jim. (2023). Β-Lactam Antibiotic Ceftriaxone As a Potential Therapeutic Intervention for Chronic Pain in Sickle Cell Disease. Blood, 142, (Supplement 1), 2495. doi:10.1182/blood-2023-188342.

Kashyap, Yavnika, He, Ying, Sadhu, Nilanjana, Yao, Yingwei, Wilkie, Diana J, Molokie, Robert E, Wang, Zaijie Jim. (2023). An alcohol dehydrogenase 7 gene polymorphism associates with both acute and chronic pain in sickle cell disease. Pharmacogenomics, 24, (12), 641-649. doi:10.2217/pgs-2023-0084.

Kashyap, Yavnika, Wang, Zaijie Jim. (2023). Reshaping the gut microbiota affects pain and anxiety-like behaviors in a transgenic model of sickle cell disease. Physiology, 38, (S1), 5732904. doi:10.1152/physiol.2023.38.s1.5732904.

Hennessy, Madeline R, Gutridge, Anna M, French, Alexander R, Rhoda, Elizabeth S, Meqbil, Yazan J, Gill, Meghna, Kashyap, Yavnika, Appourchaux, Kevin, Paul, Barnali, Wang, Zaijie Jim, van Rijn, Richard M, Riley, Andrew P. (2023). Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of Medicinal Chemistry, 66, (5), 3312-3326. doi:10.1021/acs.jmedchem.2c01707.

Han, Jiaojiao, Wang, Ziyan, Lu, Chenyang, Zhou, Jun, Li, Ye, Ming, Tinghong, Zhang, Zhen, Wang, Zaijie Jim, Su, Xiurong. (2021). The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation. Food & Function, 12, (19), 9030-9042. doi:10.1039/d1fo01884a.

He, Ying, Shi, Zuoxiao, Kashyap, Yavnika, Messing, Robert O, Wang, Zaijie Jim. (2021). Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. Pain, 162, (10), 2499-2511. doi:10.1097/j.pain.0000000000002353.

Han, Jiaojiao, Huang, Zhongbai, Tang, Shasha, Lu, Chenyang, Wan, Haitao, Zhou, Jun, Li, Ye, Ming, Tinghong, Jim Wang, Zaijie, Su, Xiurong. (2020). The novel peptides ICRD and LCGEC screened from tuna roe show antioxidative activity via Keap1/Nrf2-ARE pathway regulation and gut microbiota modulation. Food Chemistry, 327, 127094. doi:10.1016/j.foodchem.2020.127094.

Schoppee, Tasha M, Dyal, Brenda W, Scarton, Lisa, Ezenwa, Miriam O, Singh, Prashant, Yao, Yingwei, Suarez, Marie L, Wang, Zaijie J, Molokie, Robert E, Wilkie, Diana J. (2020). Patients and Caregivers Rate the PAINReportIt Wireless Internet-Enabled Tablet as a Method for Reporting Pain During End-of-Life Cancer Care.. Cancer Nursing, 43, (5), 419-424. doi:10.1097/ncc.0000000000000743.

Professional Leadership

NIH NPI Study Section, NIH, 10/1/2014 - 6/30/2021

Ontario Genomics Institute’s Scientific Advisory Group (SAG), 2012 - 2012

Education

Degrees:
Ph.D, University of California at San Francisco, United States