Your browser is unsupported

We recommend using the latest version of IE11, Edge, Chrome, Firefox or Safari.

Photo of Gail B. Mahady

Gail B. Mahady


Associate Professor, College of Pharmacy - Pharmacy Practice
Research Faculty, PAHO/WHO Collaborating Centre
Lecturer, College of Pharmacy - Pharmacognosy Graduate Program
Coordinator and Lecturer, College of Pharmacy
Coordinator, College of Pharmacy

Related Sites:

About Heading link

Research Interests:
My research interests specifically focus on natural products, traditional medicines and botanical dietary supplements and their application in the broad sense to the treatment of women’s reproductive health disorders and osteoporosis, as well as infectious diseases and their chronic health consequences. My research also is involved with understanding the association of vitamin deficiencies (particularly vitamins A and D) with the development and metastasis of epithelial cancers. Much of this work has been funded by the National Center for Complementary and Integrative Heath at the NIH, the World Health Organization, the First Analysis Institute for Integrative Health, and other foundations and funding sources.

Teaching and Supervision Heading link

Evidence Based Phytotherapy (PMPR 328), 1/10/2022 – 4/29/2022
Evidence Based Phytotherapy (PMPR 328), 1/10/2022 – 4/29/2022
Evidence Based Phytotherapy (PMPR 328), 1/13/2020 – 5/1/2020
Evidence Based Phytotherapy (PMPR 328), 1/13/2020 – 5/1/2020
Spec Project in Pharm Pract (PMPR 390), 8/27/2019 – 12/7/2019
Evidence Based Phytotherapy (PMPR 328), 1/14/2019 – 5/3/2019
Evidence Based Phytotherapy (PMPR 328), 1/14/2019 – 5/3/2019
PDAT 8: Special Topics (PHAR 508), 8/27/2018 – 12/7/2018
Spec Project in Pharm Pract (PMPR 390), 8/27/2018 – 12/7/2018

Selected Grants

Chemopreventative Effects of Dietary Supplements in a Xenograph Mouse Model, Regenstein Foundation., 3/1/2018 - 9/30/2022, Obligated Amount: $160000; Anticipated Amount: $160000

Cytotoxicity, proteomics and transcriptomics of Beta carotene, Vitamin A and D combinations in epithelial cell cancers: Whole genome analysis for epigenetic and genetic regulation, First Analysis Institute of Integrative Medicine., 1/6/2017 - 12/30/2020, No Obligated Amount Set; No Anticipated Amount Set

Botanical Dietary Supplements for Women's Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2022, Obligated Amount: $9708015; Anticipated Amount: $12588944

Osteogenic Effects of Dietary Anthocyanins in Transgenic Medaka, National Institutes of Health., 4/1/2015 - 3/31/2018, Obligated Amount: $429259; Anticipated Amount: $429259

The Search For New Plant Based Therapies, National Institutes of Health (National Center for Complementary and Integrative Health)., 8/1/2007 - 7/31/2009, Obligated Amount: $16241; Anticipated Amount: $16241

Search for Clean Mouth Sensations Used by Different Cultures, Wrigley (William) (Jr) Co., 1/1/2006 - 8/30/2007, Obligated Amount: $150000; Anticipated Amount: $150000

Botanicals From Central America for Menopause, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/15/2004 - 2/29/2008, Obligated Amount: $361741; Anticipated Amount: $361741

Conference On Emerging Research Technologies, National Institutes of Health (National Center for Complementary and Integrative Health)., 4/1/2004 - 12/31/2007, Obligated Amount: $35000; Anticipated Amount: $35000

Botanicals for the Chlamydia Pneumonia Infections, National Institutes of Health (National Center for Complementary and Integrative Health)., 2/1/2004 - 1/31/2006, Obligated Amount: $385094; Anticipated Amount: $385094

Selected Publications

Buenrostro, Karen D Garay, Mendoza, Keila C Ostos, Kanabar, Pinal N, Los, Nina S, Lawal, Temitope O, Patel, Shitalben M, López, Alice M, Cabada-Aguirre, Paulina, Mahady, Gail B, Maienschein-Cline, Mark, Arbieva, Zarema. (2022). Combination of vitamins A, D2 and D3 reduce tumor load and alter the expression of miRNAs that regulate genes involved with apoptosis, tumor suppression, and the epithelial-mesenchymal transition in HCT-116 colon cancer cells. Functional Foods in Health and Disease, 12, (5), 216-241. doi:10.31989/ffhd.v12i5.925.

Kane, Garvan C, Wicks, Sheila M, Lawal, Temitope O, Raut, Nishikant, Mahady, Gail B. (2022). Drug Interactions with Food and Beverages. Nutrition Guide for Physicians and Related Healthcare Professions. (pp. 283-294). doi:10.1007/978-3-030-82515-7_26.

Raut, Nishikant, Lawal, Temitope O, Mahady, Gail B. (2022). Chapter 13 Good quality and clinical practices for the future development of herbal medicines. Evidence-Based Validation of Herbal Medicine. (pp. 337-348). doi:10.1016/b978-0-323-85542-6.00036-6.

Lawal, Temitope O, Raut, Nishikant A, Patel, Shitalben R, Mahady, Gail B. (2021). Extracts of Anogeissus leiocarpus and Dillenia indica Inhibit the Growth of MCF-7 Breast Cancer and COV434 Granulosa Tumor Cells by Inducing Apoptosis and Autophagy. Current Bioactive Compounds, 17, (10), e190721191390. doi:10.2174/1573407217666210215092955.

Ren, Zhitao, Raut, Nishikant A, Lawal, Temitope O, Patel, Shital R, Lee, Simon M, Mahady, Gail B. (2021). Peonidin‐3‐O‐glucoside and cyanidin increase osteoblast differentiation and reduce RANKL‐induced bone resorption in transgenic medaka. Phytotherapy Research, 35, (11), 6255-6269. doi:10.1002/ptr.7271.

Ayatollahi, Seyed Abdulmajid, Sharifi-Rad, Javad, Fokou, Patrick Valere Tsouh, Mahady, Gail B, Suleria, Hafiz Ansar Rasul, Kapuganti, Shivani Krishna, Gadhave, Kundlik, Giri, Rajanish, Garg, Neha, Sharma, Rohit, Ribeiro, Daniel, Rodrigues, Célia F, Reiner, Željko, Taheri, Yasaman, Cruz-Martins, Natália. (2021). Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection. Frontiers in Pharmacology, 12, 575877. doi:10.3389/fphar.2021.575877.

Mahady, Gail, Kanabar, Pinal, Los, Nina, Lawal, Temitope, Patel, Shitalben, Maienschein-Cline, Mark, Arbieva, Zarema. (2021). Transcriptomic analysis reveals that combinations of vitamins A, D2, and D3 have synergistic effects in HCT-116 colon cancer cells by altering the expression of genes involved in multiple canonical pathways including apoptosis, regulation of the…. Functional Foods in Health and Disease, 11, (4), 154-178. doi:10.31989/ffhd.v11i4.784.

Soni, Kapil K, Meshram, Deepak, Lawal, Temitope O, Patel, Udeshi, Mahady, Gail B. (2021). Fractions of Boswellia Serrata Suppress LTA4, LTC4, Cyclooxygenase-2 Activities and mRNA in HL-60 Cells and Reduce Lung Inflammation in BALB/c Mice. Current Drug Discovery Technologies, 18, (1), 95-104. doi:10.2174/1570163817666200127112928.

Sharifi-Rad, Javad, Salehi, Bahare, Stojanović-Radić, Zorica Z, Fokou, Patrick Valere Tsouh, Sharifi-Rad, Marzieh, Mahady, Gail B, Sharifi-Rad, Majid, Masjedi, Mohammad-Reza, Lawal, Temitope O, Ayatollahi, Seyed Abdulmajid, Masjedi, Javid, Sharifi-Rad, Razieh, Setzer, William N, Sharifi-Rad, Mehdi, Kobarfard, Farzad, Rahman, Atta-Ur, Choudhary, Muhammad Iqbal, Ata, Athar, Iriti, Marcello. (2020). Medicinal plants used in the treatment of tuberculosis – Ethnobotanical and ethnopharmacological approaches. Biotechnology Advances, 44, 107629. doi:10.1016/j.biotechadv.2020.107629.

Education

Degrees:
Doctor of Philosophy, University of Illinois at Chicago, United States, 1991
Bachelors of Science, Dalhousie University, Canada, 1979

Postgraduate Training:
Postdoctoral Training, University of Illinois at Chicago, United States, 1994

Selected Presentations

Mahady, Gail. (2019 September 14). Women's Health in the Americas: The Importance of Traditional Medicine. Traditional Medicines Congress. Bangkok, Thailand.