Paola C. Rosas
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About Heading link
Overview:
My research aims to study the pathways that lead to heart failure due to stressors such as aging, obesity, and diabetes with special focus on heart failure with preserved ejection fraction (HFpEF). I also investigate the underlying mechanisms of sex differences in the incidence of heart failure. Methods include echocardiography, intra-cardiac pressure-volume measurements, simultaneous force and intracellular calcium measurements on intact papillary muscles, biochemistry techniques, phosphorylation techniques, and molecular biology techniques.
Research Interests:
Ongoing projects aim to elucidate the mechanisms of crosstalk between estrogens and P21-activated kinase 1 (PAK1) and determine the role of PAK1 in the regulation of cardiac function and adipose tissue homeostasis.
Teaching and Supervision Heading link
Applied Research Methods (PMPR 376), 1/8/2024 – 4/26/2024
Undergrad Res Exp Pharm Pract (PMPR 300), 1/8/2024 – 4/26/2024
Undergrad Resrch Pharm Pract (PMPR 380), 8/21/2023 – 12/1/2023
Integrated Physiology (PHAR 410), 8/21/2023 – 12/1/2023
Integrated Physiology (PHAR 410), 8/21/2023 – 12/1/2023
Applied Research Methods (PMPR 376), 1/9/2023 – 4/28/2023
Spec Project in Pharm Pract (PMPR 390), 1/9/2023 – 4/28/2023
Selected Grants
Exploring the microbiome of native Peruvians to understand dietary influence on cardiovascular health, American Heart Association., 4/1/2024 - 3/31/2025, Obligated Amount: $10000; Anticipated Amount: $10000
The impact of Short-chain Fatty Acids on Heart Failure with Preserved Ejection Fraction: Mechanisms and Therapeutic Implications., University of Illinois, College of Pharmacy, Vahlteich Research Award., 3/1/2024 - Present, Obligated Amount: $50000; No Anticipated Amount Set
UICHeart: University of Illinois Undergraduate Mentoring and Experience in Heart Research, American Heart Association., 1/1/2024 - 12/31/2026, Obligated Amount: $164998; Anticipated Amount: $164998
Targeting P21-activated kinase-1 to restore cardiometabolic health, UIC College of Pharmacy: Vahlteich., 12/31/2022 - Present, Obligated Amount: $50000; No Anticipated Amount Set
Engaging undergraduate Students in Cardiology Research Training (ESCoRT) Program, American Heart Association., 12/30/2022 - Present, Obligated Amount: $164471; No Anticipated Amount Set
P21-activated kinase 1 is a novel regulator of cardiac and adipose tissue function in females, National Institutes of Health (National Heart, Lung, and Blood Institute)., 8/16/2021 - 7/31/2026, Obligated Amount: $540000; Anticipated Amount: $810000
P21-Activated Kinase-1 as a Novel Regulator of Cardiac Function in Female Mice, American Heart Association., 7/1/2021 - 6/30/2024, Obligated Amount: $231000; Anticipated Amount: $231000
P21-activated Kinase as a Novel Regulator of Adiposity and Cardiac Function in Females, University of California - San Diego., 2/8/2019 - 7/31/2020, Obligated Amount: $10800; Anticipated Amount: $10800
Cardiac Myosin Binding Protein-C phosphorylation is essential to preserve diastolic function in aging hearts, American Heart Association., 7/1/2016 - 6/30/2018, Obligated Amount: $106350; No Anticipated Amount Set
Integrated Mechanisms of Cardiac Maladaptation (2 PO1 HL062426-16), National Institutes of Health (National Heart, Lung, and Blood Institute)., 6/1/2016 - 5/31/2023, Obligated Amount: $9976919; Anticipated Amount: $9976919
Selected Publications
Munoz, Marcos, Solis, Christopher, McCann, Maximilian, Park, Jooman, Rafael-Clyke, Koreena, Chowdhury, Shamim AK, Jiang, Yuwei, Rosas, Paola C. (2024). P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function. Molecular and Cellular Biochemistry, 1-15. doi:10.1007/s11010-024-04968-4.
Rosas, Paola C, Munoz, Marcos, McCann, Maximilian, Rafael-Clyke, Koreena, Park, Jooman, Chowdhury, Shamim, Jiang, Yuwei. (2023). Abstract 14169: Deletion of P21 Activated Kinase-1 Modulates Energy Homeostasis and Affects Cardiac Function. Circulation, 148, (Suppl_1), a14169-a14169. doi:10.1161/circ.148.suppl_1.14169.
Pereira, Carlos H, Bare, Dan J, Rosas, Paola C, Dias, Fernando AL, Banach, Kathrin. (2023). The role of P21-activated kinase (Pak1) in sinus node function. Journal of Molecular and Cellular Cardiology, 179, 90-101. doi:10.1016/j.yjmcc.2023.04.004.
Rosas, Paola C, Chowdhury, Shamim, Patel, Nisha. (2023). FINGOLIMOD (FTY720) IMPROVES DIASTOLIC DYSFUNCTION, FAT ACCUMULATION AND GLUCOSE HOMEOSTASIS IN A HEART FAILURE WITH PRESERVED EJECTION FRACTION MOUSE MODEL. Journal of the American College of Cardiology, 81, (8), 301. doi:10.1016/s0735-1097(23)00745-3.
Rosas, Paola C, Chowdhury, Shamim, Kurup, Shreya B, Patel, Nisha A. (2022). Abstract 13174: Cardio-Metabolic Traits of a Heart Failure With Preserved Ejection Fraction Mouse Model. Circulation, 146, (Suppl_1), a13174-a13174. doi:10.1161/circ.146.suppl_1.13174.
Neves, Liomar A, Rosas, Paola C, Wang, Hongjian, Senese, Peter B, Gralinski, Michael R. (2022). Abstract 10678: Structural and Functional Changes of the Right Ventricle in Sprague Dawley and Wistar Rat Models of Pulmonary Arterial Hypertension. Circulation, 146, (Suppl_1), a10678-a10678. doi:10.1161/circ.146.suppl_1.10678.
Rosas, Paola C, Batra, Ashley, Rafael-Clyke, Koreena, Kurup, Shreya, Chowdhury, Shamim. (2022). Abstract P3018: A Requirement For P21 Activated Kinase1 To Preserve Cardiac Function And Metabolic Homeostasis. Circulation Research, 131, (Suppl_1), ap3018-ap3018. doi:10.1161/res.131.suppl_1.p3018.
Tong, Carl Wei-Chan, Rosas, Paola C, Leatherman, Abby K, McAlister, Lillian A. (2022). CARDIAC MYOSIN BINDING PROTEIN-C MEDIATES CALCIUM TO FORCE COUPLING FOR EFFECTIVE CONTRACTION AND RELAXATION. Journal of the American College of Cardiology, 79, (9), 317. doi:10.1016/s0735-1097(22)01308-0.
Rosas, Paola C, Capote, Andrielle E, Warren, Chad M, Chowdhury, Shamim, Wolska, Beata M, Solaro, RJ. (2021). Abstract 11855: Disruption of β-arrestin-2 Signaling Resulted in Impaired Systolic and Diastolic Function During Aging. Circulation, 144, (Suppl_1), a11855-a11855. doi:10.1161/circ.144.suppl_1.11855.
Education
Degrees:
MD, Universidad Nacional de San Agustin, Peru
Pharmacy and Biochemistry, Universidad Catolica Santa Maria, Peru
PhD, Texas A&M University, United States