Shaonong Chen
Research Associate Professor, Pharmaceutical Sciences
Associate Director of Technology Resources, Pharmacognosy Institute
Institute Affiliate, Pharmacognosy Institute
Institute Affiliate, Institute for Tuberculosis Research
Contact
Address:
833 S Wood St, Chicago, IL
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About Heading link
Overview:
Over two decades in UIC, my interdisciplinary expertise in chemistry and biology focuses on the analysis of natural products, discovery of bioactive principles from plants and other natural sources, and methodological development in natural product research. This includes combining chemical and biological evaluation of natural products with chromatography, nuclear magnetic resonance (NMR), as well as mass spectrometry (MS, LC/GC-MS) that are state-of-the-art in dereplication, structure elucidation and quantification. Familiar with all major classes of NPs through almost three decades of research, I have experience as key personnel in several NIH-supported cross-disciplinary programs which I developed several innovative chemical approaches in natural product research, such as NMR guiding metabolomic mining of new phytochemicals, multi-references standardization of complex extract with NMR methodology, qualification and quantification of metabolomics by mining NMR data. My work led to the establishment of (dynamic) residual complexity to explain biological profiles that change over time; and the chemical subtraction by countercurrent separation has been extended to produce “Knock-out” and “DESIGNER” extracts which were key materials in multiple biological targets study.
Research Interests:
My interesting is mainly on the analysis of natural products, discovery of bioactive principles from different natural sources, and methodological development in natural product research. These activities include combining evaluation of natural products with chromatography, nuclear magnetic resonance (NMR and quantitative NMR), as well as mass spectrometry (MS, LC/GC-MS) that are state-of-the-art in dereplication, structure elucidation and quantification.
Teaching and Supervision Heading link
Pathophysiology, Drug Action, & Therapeutics (PDAT) 6: Infectious Diseases (PHAR 506), 2/27/2023 – 3/2/2023
Selected Grants
Dentin Biomodification or Optimization of Bioadhesive Dental Restorations, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 6/24/2023 - 4/30/2025, Obligated Amount: $840402.48; Anticipated Amount: $840402.48
Residual Complexity (RC) of Antiviral Isoquercitrin (IQC), Institut de Recherches Cliniques de Montreal., 4/11/2023 - 8/15/2024, Obligated Amount: $100000; Anticipated Amount: $100000
Modularity in Oligomeric Phenol Chemistry for Biomodulation of Dental Structures, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 2/1/2023 - 1/31/2025, Obligated Amount: $425657; Anticipated Amount: $445213
Pharmacopoeial NMR and qNMR Method Development, US Pharmacopeial Convention., 5/1/2022 - 4/30/2023, Obligated Amount: $100000; Anticipated Amount: $100000
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations, Marquette University., 5/1/2020 - 5/15/2023, Obligated Amount: $627339; Anticipated Amount: $627339
Dentin Biomodification for Optimization of Bioadhesive Dental Restorations, National Institutes of Health (National Institute of Dental and Craniofacial Research)., 7/15/2019 - 3/31/2020, Obligated Amount: $553811; Anticipated Amount: $2652925
Biomodification of Dentin Matrix Structure, National Institutes of Health (National Cancer Institute)., 9/1/2017 - 8/31/2019, Obligated Amount: $647538; Anticipated Amount: $647538
Center for Natural Product Technologies at UIC, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2020, Obligated Amount: $1456875; Anticipated Amount: $1456875
Botanical Dietary Supplements for Women's Health, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2022, Obligated Amount: $9708015; Anticipated Amount: $12588944
Selected Publications
Jing, Shu-Xi, Ferreira, Daneel, Pandey, Pankaj, Klein, Larry L, Chittiboyina, Amar Gopal, McAlpine, James B, Lankin, David C, Alania, Yvette, Reis-Havlat, Mariana, Bedran-Russo, Ana K, Chen, Shao-Nong, Pauli, Guido F. (2023). Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins. The Journal of Organic Chemistry, 88, (19), 13490-13503. doi:10.1021/acs.joc.3c00950.
Hitzman, Ryan, Malca-Garcia, Gonzalo R, Howell, Caitlin, Park, Hyun-Young, Friesen, J Brent, Dong, Huali, Dunlap, Tareisha, McAlpine, James B, Vollmer, Guenter, Bosland, Maarten C, Nikolić, Dejan, Lankin, David C, Chen, Shao-Nong, Bolton, Judy L, Pauli, Guido F, Dietz, Birgit M. (2023). DESIGNER fraction concept unmasks minor bioactive constituents in red clover (Trifolium pratense L.). Phytochemistry, 214, 113789. doi:10.1016/j.phytochem.2023.113789.
Stock, Leticia, Robinson-Mailman, Lydia, Nguyen, Long C, Chen, Shao-Nong, Pauli, Guido F, Rosner, Marsha R. (2023). Abstract 793: Mechanism of interferon induction by cannabidiol (CBD) and analogues in lung cancer cells. Cancer Research, 83, (7_Supplement), 793-793. doi:10.1158/1538-7445.am2023-793.
Tang, Yu, Friesen, J Brent, Lankin, David C, McAlpine, James B, Nikolić, Dejan, Chen, Shao-Nong, Pauli, Guido F. (2023). Geraniol-Derived Monoterpenoid Glucosides from Rhodiola rosea: Resolving Structures by QM-HifSA Methodology. Journal of Natural Products, 86, (2), 256-263. doi:10.1021/acs.jnatprod.2c00836.
Achanta, Prabhakar S, Friesen, J Brent, Harris, Guy, Webster, Gregory K, Chen, Shao-Nong, Pauli, Guido F. (2023). Development of Centrifugal Partition Chromatography for the Purification of Antibody–Drug Conjugates. Analytical Chemistry, 95, (5), 2783-2788. doi:10.1021/acs.analchem.2c03919.
Liu, Jialin, Banuvar, Suzanne, Viana, Marlos, Barengolts, Elena, Chen, Shao-Nong, Pauli, Guido F, van Breemen, Richard B. (2023). Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants. Drug Metabolism and Disposition, 51, (2), dmd-ar-2022-001050. doi:10.1124/dmd.122.001050.
Reis, M, Alania, Y, Jing, S, Alpine, JB Mc, Chen, S-N, Pauli, GF, Bedran-Russo, A. (2023). 12 Dynamic Mechanical Mapping of Methacrylate-Proanthocyanidin-Dentin Biointerfaces. Dental Materials, 39, e13. doi:10.1016/j.dental.2023.08.027.
Zhou, Bin, Alania, Yvette, Reis, Mariana, Jing, Shu-Xi, McAlpine, James B, Bedran-Russo, Ana K, Chen, Shao-Nong, Ferreira, Daneel, Pauli, Guido F. (2022). Seco B‑Type Oligomers from Pinus massoniana Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity. Journal of Natural Products, 85, (12), 2753-2768. doi:10.1021/acs.jnatprod.2c00664.
Zhou, Bin, Shetye, Gauri, Wolf, Nina M, Chen, Shao-Nong, Qader, Mallique, Ray, G Joseph, Lankin, David C, Cho, Sanghyun, Cheng, Jinhua, Suh, Joo-Won, Franzblau, Scott G, McAlpine, James B, Pauli, Guido F. (2022). New Rufomycins from Streptomyces atratus MJM3502 Expand Anti-Mycobacterium tuberculosis Structure–Activity Relationships. Organic Letters, 24, (40), 7265-7270. doi:10.1021/acs.orglett.2c02493.
Education
Degrees:
Ph.D, Lanzhou University, China, 1997
Postgraduate Training:
Post-doctoral Research Associate, Shanghai Institute of Materia Medica, China, 1999
Post-doctoral Research Associate, University of Virginia, United States, 2000
Selected Presentations
Chen, Shaonong. (2023 April 06). Creating a New Path -- New Thinking on Natural Products Research.